Zooplankton-based adverse outcome pathways: a tool for assessing endocrine disrupting compounds in aquatic environments
Endocrine disrupting compounds (EDCs) pose a significant ecological risk, particularly in aquatic ecosystems. EDCs have become a focal point in ecotoxicology, and their identification and regulation have become a priority. Zooplankton have gained global recognition as bioindicators, benefiting from...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier BV
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/117544/ http://psasir.upm.edu.my/id/eprint/117544/1/117544.pdf |
| _version_ | 1848867277347225600 |
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| author | Razak, Muhammad Raznisyafiq Wee, Sze Yee Yusoff, Fatimah Md Yusof, Zetty Norhana Balia Aris, Ahmad Zaharin |
| author_facet | Razak, Muhammad Raznisyafiq Wee, Sze Yee Yusoff, Fatimah Md Yusof, Zetty Norhana Balia Aris, Ahmad Zaharin |
| author_sort | Razak, Muhammad Raznisyafiq |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Endocrine disrupting compounds (EDCs) pose a significant ecological risk, particularly in aquatic ecosystems. EDCs have become a focal point in ecotoxicology, and their identification and regulation have become a priority. Zooplankton have gained global recognition as bioindicators, benefiting from rigorous standardization and regulatory validation processes. This review aims to provide a comprehensive summary of zooplankton-based adverse outcome pathways (AOPs) with a focus on EDCs as toxicants and the utilisation of freshwater zooplankton as bioindicators in ecotoxicological assessments. This review presents case studies in which zooplankton have been used in the development of AOPs, emphasizing the identification of molecular initiating events (MIEs) and key events (KEs) specific to zooplankton exposed to EDCs. Zooplankton-based AOPs may become an important resource for understanding the intricate processes by which EDCs impair the endocrine system. Furthermore, the data sources, experimental approaches, advantages, and challenges associated with zooplankton-based AOPs are discussed. Zooplankton-based AOPs framework can provide vital tools for consolidating toxicological knowledge into a structured toxicity pathway of EDCs, offering a transformative platform for facilitating enhanced risk assessment and chemical regulation. |
| first_indexed | 2025-11-15T14:33:56Z |
| format | Article |
| id | upm-117544 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:33:56Z |
| publishDate | 2024 |
| publisher | Elsevier BV |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1175442025-05-29T03:42:15Z http://psasir.upm.edu.my/id/eprint/117544/ Zooplankton-based adverse outcome pathways: a tool for assessing endocrine disrupting compounds in aquatic environments Razak, Muhammad Raznisyafiq Wee, Sze Yee Yusoff, Fatimah Md Yusof, Zetty Norhana Balia Aris, Ahmad Zaharin Endocrine disrupting compounds (EDCs) pose a significant ecological risk, particularly in aquatic ecosystems. EDCs have become a focal point in ecotoxicology, and their identification and regulation have become a priority. Zooplankton have gained global recognition as bioindicators, benefiting from rigorous standardization and regulatory validation processes. This review aims to provide a comprehensive summary of zooplankton-based adverse outcome pathways (AOPs) with a focus on EDCs as toxicants and the utilisation of freshwater zooplankton as bioindicators in ecotoxicological assessments. This review presents case studies in which zooplankton have been used in the development of AOPs, emphasizing the identification of molecular initiating events (MIEs) and key events (KEs) specific to zooplankton exposed to EDCs. Zooplankton-based AOPs may become an important resource for understanding the intricate processes by which EDCs impair the endocrine system. Furthermore, the data sources, experimental approaches, advantages, and challenges associated with zooplankton-based AOPs are discussed. Zooplankton-based AOPs framework can provide vital tools for consolidating toxicological knowledge into a structured toxicity pathway of EDCs, offering a transformative platform for facilitating enhanced risk assessment and chemical regulation. Elsevier BV 2024 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/117544/1/117544.pdf Razak, Muhammad Raznisyafiq and Wee, Sze Yee and Yusoff, Fatimah Md and Yusof, Zetty Norhana Balia and Aris, Ahmad Zaharin (2024) Zooplankton-based adverse outcome pathways: a tool for assessing endocrine disrupting compounds in aquatic environments. Environmental Research, 252 (pt.3). art. no. 119045. pp. 1-13. ISSN 0013-9351 https://www.sciencedirect.com/science/article/pii/S0013935124009496?via%3Dihub 10.1016/j.envres.2024.119045 |
| spellingShingle | Razak, Muhammad Raznisyafiq Wee, Sze Yee Yusoff, Fatimah Md Yusof, Zetty Norhana Balia Aris, Ahmad Zaharin Zooplankton-based adverse outcome pathways: a tool for assessing endocrine disrupting compounds in aquatic environments |
| title | Zooplankton-based adverse outcome pathways: a tool for assessing endocrine disrupting compounds in aquatic environments |
| title_full | Zooplankton-based adverse outcome pathways: a tool for assessing endocrine disrupting compounds in aquatic environments |
| title_fullStr | Zooplankton-based adverse outcome pathways: a tool for assessing endocrine disrupting compounds in aquatic environments |
| title_full_unstemmed | Zooplankton-based adverse outcome pathways: a tool for assessing endocrine disrupting compounds in aquatic environments |
| title_short | Zooplankton-based adverse outcome pathways: a tool for assessing endocrine disrupting compounds in aquatic environments |
| title_sort | zooplankton-based adverse outcome pathways: a tool for assessing endocrine disrupting compounds in aquatic environments |
| url | http://psasir.upm.edu.my/id/eprint/117544/ http://psasir.upm.edu.my/id/eprint/117544/ http://psasir.upm.edu.my/id/eprint/117544/ http://psasir.upm.edu.my/id/eprint/117544/1/117544.pdf |