Locomotion changes in methamphetamine and amphetamine withdrawal: a systematic review
Despite extensive preclinical research over the years, a significant gap remains in our understanding of the specific effects of methamphetamine (METH) and amphetamine (AMPH) withdrawal. Understanding these differences could be pivotal to unveiling the unique pathophysiology underlying each stimulan...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/117039/ http://psasir.upm.edu.my/id/eprint/117039/1/117039.pdf |
| _version_ | 1848867149763837952 |
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| author | Kumar, Jaya Naina Mohamed, Isa Mohamed, Rashidi Ugusman, Azizah Muzaimi, Mustapha Mohamed, Wael Yahaya, Mohamad Fairuz Teoh, Seong Lin Kamaluddin, Mohammad Rahim Abdul Hamid, Hafizah Mehat, Muhammad Zulfadli Shanmugam, Prem Kumar |
| author_facet | Kumar, Jaya Naina Mohamed, Isa Mohamed, Rashidi Ugusman, Azizah Muzaimi, Mustapha Mohamed, Wael Yahaya, Mohamad Fairuz Teoh, Seong Lin Kamaluddin, Mohammad Rahim Abdul Hamid, Hafizah Mehat, Muhammad Zulfadli Shanmugam, Prem Kumar |
| author_sort | Kumar, Jaya |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Despite extensive preclinical research over the years, a significant gap remains in our understanding of the specific effects of methamphetamine (METH) and amphetamine (AMPH) withdrawal. Understanding these differences could be pivotal to unveiling the unique pathophysiology underlying each stimulant. This may facilitate the development of targeted and effective treatment strategies tailored to the specific characteristics of each substance. Following PRISMA guidelines, this systematic review was conducted to examine alterations in spontaneous locomotor activity, specifically horizontal activity, in animals experiencing withdrawal from extended and repeated administration of AMPH or METH. Original articles were retrieved from four electronic databases, supplemented by a review of the references cited in the published papers. A total of thirty-one full-length articles (n = 31) were incorporated in the analysis. The results indicated that six studies documented a significant increase in horizontal activity among animals, seven studies reported decreased locomotion, and eighteen studies (8 AMPH; 10 METH) reported no significant alterations in the animals’ locomotor activity. Studies reporting heightened locomotion mainly employed mice undergoing withdrawal from METH, studies reporting diminished locomotion predominantly involved rats undergoing withdrawal from AMPH, and studies reporting no significant changes in horizontal activity employed both rats and mice (12 rats; 6 mice). Drug characteristics, routes of administration, animal models, dosage regimens, duration, and assessment timing seem to influence the observed outcomes. Despite more than 50% of papers enlisted in this review indicate no significant changes in the locomotion during the stimulant withdrawal, the unique reactions of animals to withdrawal from METH and AMPH reported by some underscore the need for a more nuanced understanding of stimulant withdrawal. |
| first_indexed | 2025-11-15T14:31:55Z |
| format | Article |
| id | upm-117039 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:31:55Z |
| publishDate | 2024 |
| publisher | Frontiers Media |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1170392025-04-23T04:25:53Z http://psasir.upm.edu.my/id/eprint/117039/ Locomotion changes in methamphetamine and amphetamine withdrawal: a systematic review Kumar, Jaya Naina Mohamed, Isa Mohamed, Rashidi Ugusman, Azizah Muzaimi, Mustapha Mohamed, Wael Yahaya, Mohamad Fairuz Teoh, Seong Lin Kamaluddin, Mohammad Rahim Abdul Hamid, Hafizah Mehat, Muhammad Zulfadli Shanmugam, Prem Kumar Despite extensive preclinical research over the years, a significant gap remains in our understanding of the specific effects of methamphetamine (METH) and amphetamine (AMPH) withdrawal. Understanding these differences could be pivotal to unveiling the unique pathophysiology underlying each stimulant. This may facilitate the development of targeted and effective treatment strategies tailored to the specific characteristics of each substance. Following PRISMA guidelines, this systematic review was conducted to examine alterations in spontaneous locomotor activity, specifically horizontal activity, in animals experiencing withdrawal from extended and repeated administration of AMPH or METH. Original articles were retrieved from four electronic databases, supplemented by a review of the references cited in the published papers. A total of thirty-one full-length articles (n = 31) were incorporated in the analysis. The results indicated that six studies documented a significant increase in horizontal activity among animals, seven studies reported decreased locomotion, and eighteen studies (8 AMPH; 10 METH) reported no significant alterations in the animals’ locomotor activity. Studies reporting heightened locomotion mainly employed mice undergoing withdrawal from METH, studies reporting diminished locomotion predominantly involved rats undergoing withdrawal from AMPH, and studies reporting no significant changes in horizontal activity employed both rats and mice (12 rats; 6 mice). Drug characteristics, routes of administration, animal models, dosage regimens, duration, and assessment timing seem to influence the observed outcomes. Despite more than 50% of papers enlisted in this review indicate no significant changes in the locomotion during the stimulant withdrawal, the unique reactions of animals to withdrawal from METH and AMPH reported by some underscore the need for a more nuanced understanding of stimulant withdrawal. Frontiers Media 2024 Article PeerReviewed text en cc_by_4 http://psasir.upm.edu.my/id/eprint/117039/1/117039.pdf Kumar, Jaya and Naina Mohamed, Isa and Mohamed, Rashidi and Ugusman, Azizah and Muzaimi, Mustapha and Mohamed, Wael and Yahaya, Mohamad Fairuz and Teoh, Seong Lin and Kamaluddin, Mohammad Rahim and Abdul Hamid, Hafizah and Mehat, Muhammad Zulfadli and Shanmugam, Prem Kumar (2024) Locomotion changes in methamphetamine and amphetamine withdrawal: a systematic review. Frontiers in Pharmacology, 15. art. no. 1428492. ISSN 1663-9812; eISSN: 1663-9812 https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1428492/full 10.3389/fphar.2024.1428492 |
| spellingShingle | Kumar, Jaya Naina Mohamed, Isa Mohamed, Rashidi Ugusman, Azizah Muzaimi, Mustapha Mohamed, Wael Yahaya, Mohamad Fairuz Teoh, Seong Lin Kamaluddin, Mohammad Rahim Abdul Hamid, Hafizah Mehat, Muhammad Zulfadli Shanmugam, Prem Kumar Locomotion changes in methamphetamine and amphetamine withdrawal: a systematic review |
| title | Locomotion changes in methamphetamine and amphetamine withdrawal: a systematic review |
| title_full | Locomotion changes in methamphetamine and amphetamine withdrawal: a systematic review |
| title_fullStr | Locomotion changes in methamphetamine and amphetamine withdrawal: a systematic review |
| title_full_unstemmed | Locomotion changes in methamphetamine and amphetamine withdrawal: a systematic review |
| title_short | Locomotion changes in methamphetamine and amphetamine withdrawal: a systematic review |
| title_sort | locomotion changes in methamphetamine and amphetamine withdrawal: a systematic review |
| url | http://psasir.upm.edu.my/id/eprint/117039/ http://psasir.upm.edu.my/id/eprint/117039/ http://psasir.upm.edu.my/id/eprint/117039/ http://psasir.upm.edu.my/id/eprint/117039/1/117039.pdf |