Evaluating the roles of microRNAs associated with nonalcoholic fatty liver disease in hepatocellular carcinoma tumorigenesis: a systematic review and network analysis
Introduction: Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease worldwide. Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide, with high morbidity and mortality. The rapidly increasing incidence of NAFLD is becoming an essential...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media SA
2024
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/117006/ http://psasir.upm.edu.my/id/eprint/117006/1/117006.pdf |
| _version_ | 1848867140738744320 |
|---|---|
| author | Peng, Qinghua Zhu, Xiaoning Jiang, Yuanyuan Peng, Mengyun Zheng, Ding Wang, Xiaodong Cheah, Yoke Kqueen Wang, Jing |
| author_facet | Peng, Qinghua Zhu, Xiaoning Jiang, Yuanyuan Peng, Mengyun Zheng, Ding Wang, Xiaodong Cheah, Yoke Kqueen Wang, Jing |
| author_sort | Peng, Qinghua |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Introduction: Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease worldwide. Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide, with high morbidity and mortality. The rapidly increasing incidence of NAFLD is becoming an essential precursor of HCC globally. MicroRNAs (miRNAs) are involved in the progression of NAFLD and HCC. Method: Potential miRNAs associated with NAFLD in HCC tumorigenesis were identified through a systematic review, and their roles were evaluated by data mining analysis. The biological function of the potential miRNA and its target genes in NAFLD and HCC were evaluated by bioinformatic analysis. Result: MIR122 was identified as the potential miRNA associated with NAFLD and HCC. Then, MIR122 expression was significantly lower in HCC patients, and higher MIR122 levels were associated with significantly better overall survival. Next, the biological functions of MIR122 and target genes were predicted to be involved in inflammation, fibrosis, cell proliferation, invasion, metastasis, and apoptosis. In particular, the FOXO signaling pathway may regulate the above biological functions. Conclusion: MIR122 was suggested to be involved in progressing from NAFLD to HCC through the PI3K/AKT/FOXO pathway. |
| first_indexed | 2025-11-15T14:31:46Z |
| format | Article |
| id | upm-117006 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:31:46Z |
| publishDate | 2024 |
| publisher | Frontiers Media SA |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1170062025-04-23T00:07:28Z http://psasir.upm.edu.my/id/eprint/117006/ Evaluating the roles of microRNAs associated with nonalcoholic fatty liver disease in hepatocellular carcinoma tumorigenesis: a systematic review and network analysis Peng, Qinghua Zhu, Xiaoning Jiang, Yuanyuan Peng, Mengyun Zheng, Ding Wang, Xiaodong Cheah, Yoke Kqueen Wang, Jing Introduction: Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease worldwide. Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide, with high morbidity and mortality. The rapidly increasing incidence of NAFLD is becoming an essential precursor of HCC globally. MicroRNAs (miRNAs) are involved in the progression of NAFLD and HCC. Method: Potential miRNAs associated with NAFLD in HCC tumorigenesis were identified through a systematic review, and their roles were evaluated by data mining analysis. The biological function of the potential miRNA and its target genes in NAFLD and HCC were evaluated by bioinformatic analysis. Result: MIR122 was identified as the potential miRNA associated with NAFLD and HCC. Then, MIR122 expression was significantly lower in HCC patients, and higher MIR122 levels were associated with significantly better overall survival. Next, the biological functions of MIR122 and target genes were predicted to be involved in inflammation, fibrosis, cell proliferation, invasion, metastasis, and apoptosis. In particular, the FOXO signaling pathway may regulate the above biological functions. Conclusion: MIR122 was suggested to be involved in progressing from NAFLD to HCC through the PI3K/AKT/FOXO pathway. Frontiers Media SA 2024 Article PeerReviewed text en cc_by_4 http://psasir.upm.edu.my/id/eprint/117006/1/117006.pdf Peng, Qinghua and Zhu, Xiaoning and Jiang, Yuanyuan and Peng, Mengyun and Zheng, Ding and Wang, Xiaodong and Cheah, Yoke Kqueen and Wang, Jing (2024) Evaluating the roles of microRNAs associated with nonalcoholic fatty liver disease in hepatocellular carcinoma tumorigenesis: a systematic review and network analysis. Frontiers in Medicine, 11. art. no. 1462513. pp. 1-8. ISSN 2296-858X https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1462513/full 10.3389/fmed.2024.1462513 |
| spellingShingle | Peng, Qinghua Zhu, Xiaoning Jiang, Yuanyuan Peng, Mengyun Zheng, Ding Wang, Xiaodong Cheah, Yoke Kqueen Wang, Jing Evaluating the roles of microRNAs associated with nonalcoholic fatty liver disease in hepatocellular carcinoma tumorigenesis: a systematic review and network analysis |
| title | Evaluating the roles of microRNAs associated with nonalcoholic fatty liver disease in hepatocellular carcinoma tumorigenesis: a systematic review and network analysis |
| title_full | Evaluating the roles of microRNAs associated with nonalcoholic fatty liver disease in hepatocellular carcinoma tumorigenesis: a systematic review and network analysis |
| title_fullStr | Evaluating the roles of microRNAs associated with nonalcoholic fatty liver disease in hepatocellular carcinoma tumorigenesis: a systematic review and network analysis |
| title_full_unstemmed | Evaluating the roles of microRNAs associated with nonalcoholic fatty liver disease in hepatocellular carcinoma tumorigenesis: a systematic review and network analysis |
| title_short | Evaluating the roles of microRNAs associated with nonalcoholic fatty liver disease in hepatocellular carcinoma tumorigenesis: a systematic review and network analysis |
| title_sort | evaluating the roles of micrornas associated with nonalcoholic fatty liver disease in hepatocellular carcinoma tumorigenesis: a systematic review and network analysis |
| url | http://psasir.upm.edu.my/id/eprint/117006/ http://psasir.upm.edu.my/id/eprint/117006/ http://psasir.upm.edu.my/id/eprint/117006/ http://psasir.upm.edu.my/id/eprint/117006/1/117006.pdf |