Effect of palm oil carotene on breast cancer tumorigenicity in nude mice
Biological therapies are new additions to breast cancer treatment. Among biological compounds, β-carotene has been reported to have immune modulatory effects, in particular, enhancement of natural killer cell activity and tumor necrosis factor-alpha production by macrophages. The objective of this s...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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AOCS Press
2002
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| Online Access: | http://psasir.upm.edu.my/id/eprint/116749/ http://psasir.upm.edu.my/id/eprint/116749/1/116749.pdf |
| _version_ | 1848867082054139904 |
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| author | Nesaretnam, Kalanithi Radhakrishnan, Ammu Selvaduray, Kanga Rani Reimann, Karin Pailoor, Jayalakshmi Razak, Ghazali Mustafa Mahmood, Mina Dahliwal, Jasbir Singh |
| author_facet | Nesaretnam, Kalanithi Radhakrishnan, Ammu Selvaduray, Kanga Rani Reimann, Karin Pailoor, Jayalakshmi Razak, Ghazali Mustafa Mahmood, Mina Dahliwal, Jasbir Singh |
| author_sort | Nesaretnam, Kalanithi |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Biological therapies are new additions to breast cancer treatment. Among biological compounds, β-carotene has been reported to have immune modulatory effects, in particular, enhancement of natural killer cell activity and tumor necrosis factor-alpha production by macrophages. The objective of this study was to investigate the effect of palm carotene supplementation on the tumorigenicity of MCF-7 human breast cancer cells injected into athymic nude mice and to explore the mechanism by which palm carotenes suppress tumorigenesis. Forty-eight 4-wk-old mice were injected with 1 ×106 MCF-7 cells into their mammary fat pad. The experimental group was supplemented with palm carotene whereas the control group was not. Significant differences were observed in tumor incidence (P < 0.001) and tumor surface area and metastasis to lung (P < 0.005) between the two groups. Natural killer (NK) cells and B-lymphocytes in the peripheral blood of carotene-supplemented mice were significantly increased (P < 0.05 and P < 0.001, respectively) compared with controls. These results suggest that palm oil carotene is able to modulate the immune system by increasing peripheral blood NK cells and B-lymphocytes and suppress the growth of MCF-7 human breast cancer cells. |
| first_indexed | 2025-11-15T14:30:50Z |
| format | Article |
| id | upm-116749 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:30:50Z |
| publishDate | 2002 |
| publisher | AOCS Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1167492025-07-04T08:18:10Z http://psasir.upm.edu.my/id/eprint/116749/ Effect of palm oil carotene on breast cancer tumorigenicity in nude mice Nesaretnam, Kalanithi Radhakrishnan, Ammu Selvaduray, Kanga Rani Reimann, Karin Pailoor, Jayalakshmi Razak, Ghazali Mustafa Mahmood, Mina Dahliwal, Jasbir Singh Biological therapies are new additions to breast cancer treatment. Among biological compounds, β-carotene has been reported to have immune modulatory effects, in particular, enhancement of natural killer cell activity and tumor necrosis factor-alpha production by macrophages. The objective of this study was to investigate the effect of palm carotene supplementation on the tumorigenicity of MCF-7 human breast cancer cells injected into athymic nude mice and to explore the mechanism by which palm carotenes suppress tumorigenesis. Forty-eight 4-wk-old mice were injected with 1 ×106 MCF-7 cells into their mammary fat pad. The experimental group was supplemented with palm carotene whereas the control group was not. Significant differences were observed in tumor incidence (P < 0.001) and tumor surface area and metastasis to lung (P < 0.005) between the two groups. Natural killer (NK) cells and B-lymphocytes in the peripheral blood of carotene-supplemented mice were significantly increased (P < 0.05 and P < 0.001, respectively) compared with controls. These results suggest that palm oil carotene is able to modulate the immune system by increasing peripheral blood NK cells and B-lymphocytes and suppress the growth of MCF-7 human breast cancer cells. AOCS Press 2002 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/116749/1/116749.pdf Nesaretnam, Kalanithi and Radhakrishnan, Ammu and Selvaduray, Kanga Rani and Reimann, Karin and Pailoor, Jayalakshmi and Razak, Ghazali and Mustafa Mahmood, Mina and Dahliwal, Jasbir Singh (2002) Effect of palm oil carotene on breast cancer tumorigenicity in nude mice. Lipids, 37 (6). pp. 557-560. ISSN 0024-4201 https://aocs.onlinelibrary.wiley.com/doi/10.1007/s11745-002-0932-0 10.1007/s11745-002-0932-0 |
| spellingShingle | Nesaretnam, Kalanithi Radhakrishnan, Ammu Selvaduray, Kanga Rani Reimann, Karin Pailoor, Jayalakshmi Razak, Ghazali Mustafa Mahmood, Mina Dahliwal, Jasbir Singh Effect of palm oil carotene on breast cancer tumorigenicity in nude mice |
| title | Effect of palm oil carotene on breast cancer tumorigenicity in nude mice |
| title_full | Effect of palm oil carotene on breast cancer tumorigenicity in nude mice |
| title_fullStr | Effect of palm oil carotene on breast cancer tumorigenicity in nude mice |
| title_full_unstemmed | Effect of palm oil carotene on breast cancer tumorigenicity in nude mice |
| title_short | Effect of palm oil carotene on breast cancer tumorigenicity in nude mice |
| title_sort | effect of palm oil carotene on breast cancer tumorigenicity in nude mice |
| url | http://psasir.upm.edu.my/id/eprint/116749/ http://psasir.upm.edu.my/id/eprint/116749/ http://psasir.upm.edu.my/id/eprint/116749/ http://psasir.upm.edu.my/id/eprint/116749/1/116749.pdf |