Assessment of antioxidant, antimicrobial and wound healing potential of golden chicken fern (Cibotiumbarometz (L.)J. Sm.) methanolic extracts
Cibotium barometz (L.)J. Sm., also known as the golden chicken fern, is valued in traditional Chinese medicine, particularly for its rhizome and golden hairs, which are reputed to have medicinal properties. However, there is limited scientific evidence supporting the wound-healing properties of its...
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| Format: | Article |
| Language: | English |
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Hibiscus Publisher Enterprise
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/116505/ http://psasir.upm.edu.my/id/eprint/116505/1/116505.pdf |
| _version_ | 1848867020051841024 |
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| author | Rosdin, Nursyamila Izzatie Khayat, Mohd Ezuan Chia, Suet Lin Halim, Murni Wasoh, Helmi Sobri, Zulfazli M. |
| author_facet | Rosdin, Nursyamila Izzatie Khayat, Mohd Ezuan Chia, Suet Lin Halim, Murni Wasoh, Helmi Sobri, Zulfazli M. |
| author_sort | Rosdin, Nursyamila Izzatie |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Cibotium barometz (L.)J. Sm., also known as the golden chicken fern, is valued in traditional Chinese medicine, particularly for its rhizome and golden hairs, which are reputed to have medicinal properties. However, there is limited scientific evidence supporting the wound-healing properties of its golden hairs. This study aims to evaluate the antioxidant, antimicrobial, and wound-healing potential of extracts from these hairs. The golden hairs were extracted with 80% methanol to isolate bioactive compounds. Antioxidant activity was measured using the DPPH radical scavenging assay, and total phenolic content (TPC) and total flavonoid content (TFC) were assessed. TFC was found to be higher than TPC, with values of 331 ± 0.011 mg QE/g and 67.36 ± 0.014 mg GAE/g, respectively. The antimicrobial properties of the extract were tested against Staphylococcus aureus, Bacillus cereus, Escherichia coli, and Serratia marcescens using agar well diffusion; no inhibition zones were observed, indicating a lack of antimicrobial activity. Further assays, including cytotoxicity and wound scratch tests on normal human dermal fibroblast (NHDF) cells, revealed that the extract did not promote wound healing and suppressed NHDF cell growth at a concentration of 10 mg/mL. In conclusion, while C. barometz golden hairs are traditionally valued, this study found limited antioxidant activity and no antimicrobial or wound-healing efficacy in the extract. |
| first_indexed | 2025-11-15T14:29:51Z |
| format | Article |
| id | upm-116505 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:29:51Z |
| publishDate | 2024 |
| publisher | Hibiscus Publisher Enterprise |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1165052025-04-09T06:53:29Z http://psasir.upm.edu.my/id/eprint/116505/ Assessment of antioxidant, antimicrobial and wound healing potential of golden chicken fern (Cibotiumbarometz (L.)J. Sm.) methanolic extracts Rosdin, Nursyamila Izzatie Khayat, Mohd Ezuan Chia, Suet Lin Halim, Murni Wasoh, Helmi Sobri, Zulfazli M. Cibotium barometz (L.)J. Sm., also known as the golden chicken fern, is valued in traditional Chinese medicine, particularly for its rhizome and golden hairs, which are reputed to have medicinal properties. However, there is limited scientific evidence supporting the wound-healing properties of its golden hairs. This study aims to evaluate the antioxidant, antimicrobial, and wound-healing potential of extracts from these hairs. The golden hairs were extracted with 80% methanol to isolate bioactive compounds. Antioxidant activity was measured using the DPPH radical scavenging assay, and total phenolic content (TPC) and total flavonoid content (TFC) were assessed. TFC was found to be higher than TPC, with values of 331 ± 0.011 mg QE/g and 67.36 ± 0.014 mg GAE/g, respectively. The antimicrobial properties of the extract were tested against Staphylococcus aureus, Bacillus cereus, Escherichia coli, and Serratia marcescens using agar well diffusion; no inhibition zones were observed, indicating a lack of antimicrobial activity. Further assays, including cytotoxicity and wound scratch tests on normal human dermal fibroblast (NHDF) cells, revealed that the extract did not promote wound healing and suppressed NHDF cell growth at a concentration of 10 mg/mL. In conclusion, while C. barometz golden hairs are traditionally valued, this study found limited antioxidant activity and no antimicrobial or wound-healing efficacy in the extract. Hibiscus Publisher Enterprise 2024 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/116505/1/116505.pdf Rosdin, Nursyamila Izzatie and Khayat, Mohd Ezuan and Chia, Suet Lin and Halim, Murni and Wasoh, Helmi and Sobri, Zulfazli M. (2024) Assessment of antioxidant, antimicrobial and wound healing potential of golden chicken fern (Cibotiumbarometz (L.)J. Sm.) methanolic extracts. Journal of Biochemistry, Microbiology and Biotechnology, 12 (2). pp. 16-23. ISSN 2289-5779 https://journal.hibiscuspublisher.com/index.php/JOBIMB/article/view/1013 10.54987/jobimb.v12i2.1013 |
| spellingShingle | Rosdin, Nursyamila Izzatie Khayat, Mohd Ezuan Chia, Suet Lin Halim, Murni Wasoh, Helmi Sobri, Zulfazli M. Assessment of antioxidant, antimicrobial and wound healing potential of golden chicken fern (Cibotiumbarometz (L.)J. Sm.) methanolic extracts |
| title | Assessment of antioxidant, antimicrobial and wound healing potential of golden chicken fern (Cibotiumbarometz (L.)J. Sm.) methanolic extracts |
| title_full | Assessment of antioxidant, antimicrobial and wound healing potential of golden chicken fern (Cibotiumbarometz (L.)J. Sm.) methanolic extracts |
| title_fullStr | Assessment of antioxidant, antimicrobial and wound healing potential of golden chicken fern (Cibotiumbarometz (L.)J. Sm.) methanolic extracts |
| title_full_unstemmed | Assessment of antioxidant, antimicrobial and wound healing potential of golden chicken fern (Cibotiumbarometz (L.)J. Sm.) methanolic extracts |
| title_short | Assessment of antioxidant, antimicrobial and wound healing potential of golden chicken fern (Cibotiumbarometz (L.)J. Sm.) methanolic extracts |
| title_sort | assessment of antioxidant, antimicrobial and wound healing potential of golden chicken fern (cibotiumbarometz (l.)j. sm.) methanolic extracts |
| url | http://psasir.upm.edu.my/id/eprint/116505/ http://psasir.upm.edu.my/id/eprint/116505/ http://psasir.upm.edu.my/id/eprint/116505/ http://psasir.upm.edu.my/id/eprint/116505/1/116505.pdf |