Association between physiological responses and heat shock protein 70 (HSP70) expressions in the vulnerable populations of Kuala Lumpur
Continued heat exposure can cause physiological and cellular responses. This study investigated the association between physiological responses and heat shock protein 70 (HSP70) expressions in Kuala Lumpur's urban vulnerable population. We conducted a cross-sectional study involving 54 particip...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor and Francis
2024
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/116232/ http://psasir.upm.edu.my/id/eprint/116232/1/116232.pdf |
| _version_ | 1848866955075780608 |
|---|---|
| author | Muhamad, Siti Nurfahirah Lim, Fang Lee Md Akim, Abdah Karuppiah, Karmegam Mohd Shabri, Nur Shabrina Azreen How, Vivien |
| author_facet | Muhamad, Siti Nurfahirah Lim, Fang Lee Md Akim, Abdah Karuppiah, Karmegam Mohd Shabri, Nur Shabrina Azreen How, Vivien |
| author_sort | Muhamad, Siti Nurfahirah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Continued heat exposure can cause physiological and cellular responses. This study investigated the association between physiological responses and heat shock protein 70 (HSP70) expressions in Kuala Lumpur's urban vulnerable population. We conducted a cross-sectional study involving 54 participants from four areas classified as experiencing moderate to strong heat stress. Physiological measurements included core body temperature, heart rate, and diastolic and systolic blood pressure. RT-qPCR and ELISA were also performed on blood samples to assess HSP70 gene and protein expressions. Despite indoor heat stress, participants maintained normal physiological parameters while there were significant indications of HSP70 expression at both the gene and protein levels. However, our study found no significant correlation (p > 0.05) between physiological responses and HSP70 expressions. This study shows no interaction between physiological responses and HSP70 expressions in the study population, revealing the complex mechanisms of indoor heat stress in vulnerable individuals. |
| first_indexed | 2025-11-15T14:28:49Z |
| format | Article |
| id | upm-116232 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:28:49Z |
| publishDate | 2024 |
| publisher | Taylor and Francis |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1162322025-03-24T03:26:07Z http://psasir.upm.edu.my/id/eprint/116232/ Association between physiological responses and heat shock protein 70 (HSP70) expressions in the vulnerable populations of Kuala Lumpur Muhamad, Siti Nurfahirah Lim, Fang Lee Md Akim, Abdah Karuppiah, Karmegam Mohd Shabri, Nur Shabrina Azreen How, Vivien Continued heat exposure can cause physiological and cellular responses. This study investigated the association between physiological responses and heat shock protein 70 (HSP70) expressions in Kuala Lumpur's urban vulnerable population. We conducted a cross-sectional study involving 54 participants from four areas classified as experiencing moderate to strong heat stress. Physiological measurements included core body temperature, heart rate, and diastolic and systolic blood pressure. RT-qPCR and ELISA were also performed on blood samples to assess HSP70 gene and protein expressions. Despite indoor heat stress, participants maintained normal physiological parameters while there were significant indications of HSP70 expression at both the gene and protein levels. However, our study found no significant correlation (p > 0.05) between physiological responses and HSP70 expressions. This study shows no interaction between physiological responses and HSP70 expressions in the study population, revealing the complex mechanisms of indoor heat stress in vulnerable individuals. Taylor and Francis 2024 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/116232/1/116232.pdf Muhamad, Siti Nurfahirah and Lim, Fang Lee and Md Akim, Abdah and Karuppiah, Karmegam and Mohd Shabri, Nur Shabrina Azreen and How, Vivien (2024) Association between physiological responses and heat shock protein 70 (HSP70) expressions in the vulnerable populations of Kuala Lumpur. International Journal of Environmental Health Research, 35 (1). pp. 1-11. ISSN 0960-3123; eISSN: 1369-1619 https://www.tandfonline.com/doi/full/10.1080/09603123.2024.2340125 10.1080/09603123.2024.2340125 |
| spellingShingle | Muhamad, Siti Nurfahirah Lim, Fang Lee Md Akim, Abdah Karuppiah, Karmegam Mohd Shabri, Nur Shabrina Azreen How, Vivien Association between physiological responses and heat shock protein 70 (HSP70) expressions in the vulnerable populations of Kuala Lumpur |
| title | Association between physiological responses and heat shock protein 70 (HSP70) expressions in the vulnerable populations of Kuala Lumpur |
| title_full | Association between physiological responses and heat shock protein 70 (HSP70) expressions in the vulnerable populations of Kuala Lumpur |
| title_fullStr | Association between physiological responses and heat shock protein 70 (HSP70) expressions in the vulnerable populations of Kuala Lumpur |
| title_full_unstemmed | Association between physiological responses and heat shock protein 70 (HSP70) expressions in the vulnerable populations of Kuala Lumpur |
| title_short | Association between physiological responses and heat shock protein 70 (HSP70) expressions in the vulnerable populations of Kuala Lumpur |
| title_sort | association between physiological responses and heat shock protein 70 (hsp70) expressions in the vulnerable populations of kuala lumpur |
| url | http://psasir.upm.edu.my/id/eprint/116232/ http://psasir.upm.edu.my/id/eprint/116232/ http://psasir.upm.edu.my/id/eprint/116232/ http://psasir.upm.edu.my/id/eprint/116232/1/116232.pdf |