Ultrastructural pathology of nasal and tracheal mucosa of rabbits experimentally infected with Pasteurella multocida serotype D:1
Sixteen 8- to 9-week-old Pasteurella multocida-free New Zealand White rabbits were dividec into two equal groups. The first group was inoculated intranasally with P multocida serotype D:1 strain and the second group that was inoculated with phosphate-buffered saline (PBS) only was used as a control...
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| Format: | Article |
| Language: | English |
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Elsevier
2001
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| Online Access: | http://psasir.upm.edu.my/id/eprint/116212/ http://psasir.upm.edu.my/id/eprint/116212/1/116212.pdf |
| _version_ | 1848866950264913920 |
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| author | AL-HADDAWI, M.H. JASNI, S. ISRAF, D.A. ZAMRI-SAAD, M. MUTALIB, A.R. SHEIKH-OMAR, A.R. |
| author_facet | AL-HADDAWI, M.H. JASNI, S. ISRAF, D.A. ZAMRI-SAAD, M. MUTALIB, A.R. SHEIKH-OMAR, A.R. |
| author_sort | AL-HADDAWI, M.H. |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Sixteen 8- to 9-week-old Pasteurella multocida-free New Zealand White rabbits were dividec into two equal groups. The first group was inoculated intranasally with P multocida serotype D:1 strain and the second group that was inoculated with phosphate-buffered saline (PBS) only was used as a control group. Pasteurella multocida was isolated from the nasal cavity of all infected rabbits in group 1 and from tracheal swabs of seven rabbits in this group. Four rabbits in group 1 died with clinical signs of septicaemia, two rabbits had mucopurulent nasal discharge and pneumonic lesions and the other two did not show any clinical signs or gross lesions. The ultrastructural changes detected were deciliation or clumping of cilia of ciliated epithelium, cellular swelling, vacuolation and sloughing. The subepithelial capillaries showed congestion, intravascular fibrin deposition, platelets aggregation and endothelial injury. Pasteurella multocida was observed attached to the injured endothelial cells. Heterophils, mast cells, vacuolated monocytes and macrophages infiltrated the lamina propria and between the degenerated epithelial cells. ©2001 Harcourt Publishers Ltd. |
| first_indexed | 2025-11-15T14:28:44Z |
| format | Article |
| id | upm-116212 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:28:44Z |
| publishDate | 2001 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1162122025-03-20T08:23:48Z http://psasir.upm.edu.my/id/eprint/116212/ Ultrastructural pathology of nasal and tracheal mucosa of rabbits experimentally infected with Pasteurella multocida serotype D:1 AL-HADDAWI, M.H. JASNI, S. ISRAF, D.A. ZAMRI-SAAD, M. MUTALIB, A.R. SHEIKH-OMAR, A.R. Sixteen 8- to 9-week-old Pasteurella multocida-free New Zealand White rabbits were dividec into two equal groups. The first group was inoculated intranasally with P multocida serotype D:1 strain and the second group that was inoculated with phosphate-buffered saline (PBS) only was used as a control group. Pasteurella multocida was isolated from the nasal cavity of all infected rabbits in group 1 and from tracheal swabs of seven rabbits in this group. Four rabbits in group 1 died with clinical signs of septicaemia, two rabbits had mucopurulent nasal discharge and pneumonic lesions and the other two did not show any clinical signs or gross lesions. The ultrastructural changes detected were deciliation or clumping of cilia of ciliated epithelium, cellular swelling, vacuolation and sloughing. The subepithelial capillaries showed congestion, intravascular fibrin deposition, platelets aggregation and endothelial injury. Pasteurella multocida was observed attached to the injured endothelial cells. Heterophils, mast cells, vacuolated monocytes and macrophages infiltrated the lamina propria and between the degenerated epithelial cells. ©2001 Harcourt Publishers Ltd. Elsevier 2001 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/116212/1/116212.pdf AL-HADDAWI, M.H. and JASNI, S. and ISRAF, D.A. and ZAMRI-SAAD, M. and MUTALIB, A.R. and SHEIKH-OMAR, A.R. (2001) Ultrastructural pathology of nasal and tracheal mucosa of rabbits experimentally infected with Pasteurella multocida serotype D:1. Research in Veterinary Science, 70 (3). pp. 191-197. ISSN 0034-5288; eISSN: 0034-5288 https://linkinghub.elsevier.com/retrieve/pii/S003452880190459X 10.1053/rvsc.2001.0459 |
| spellingShingle | AL-HADDAWI, M.H. JASNI, S. ISRAF, D.A. ZAMRI-SAAD, M. MUTALIB, A.R. SHEIKH-OMAR, A.R. Ultrastructural pathology of nasal and tracheal mucosa of rabbits experimentally infected with Pasteurella multocida serotype D:1 |
| title | Ultrastructural pathology of nasal and tracheal mucosa of rabbits experimentally infected with Pasteurella multocida serotype D:1 |
| title_full | Ultrastructural pathology of nasal and tracheal mucosa of rabbits experimentally infected with Pasteurella multocida serotype D:1 |
| title_fullStr | Ultrastructural pathology of nasal and tracheal mucosa of rabbits experimentally infected with Pasteurella multocida serotype D:1 |
| title_full_unstemmed | Ultrastructural pathology of nasal and tracheal mucosa of rabbits experimentally infected with Pasteurella multocida serotype D:1 |
| title_short | Ultrastructural pathology of nasal and tracheal mucosa of rabbits experimentally infected with Pasteurella multocida serotype D:1 |
| title_sort | ultrastructural pathology of nasal and tracheal mucosa of rabbits experimentally infected with pasteurella multocida serotype d:1 |
| url | http://psasir.upm.edu.my/id/eprint/116212/ http://psasir.upm.edu.my/id/eprint/116212/ http://psasir.upm.edu.my/id/eprint/116212/ http://psasir.upm.edu.my/id/eprint/116212/1/116212.pdf |