Flavonoid diversity and roles in the lipopolysaccharide-mediated inflammatory response of monocytes and macrophages
Targeting lipopolysaccharide (LPS)/toll-like receptor 4 signaling in mononuclear phagocytes has been explored for the treatment of inflammation and inflammation-related disorders. However, only a few key targets have been translated into clinical applications. Flavonoids, a class of ubiquitous plant...
| Main Authors: | , , , |
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| Format: | Article |
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Newlands Press
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/116067/ |
| _version_ | 1848866920592310272 |
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| author | Rullah, Kamal Shamsudin, Nur Farisya Koeberle, Andreas Tham, Chau Ling |
| author_facet | Rullah, Kamal Shamsudin, Nur Farisya Koeberle, Andreas Tham, Chau Ling |
| author_sort | Rullah, Kamal |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Targeting lipopolysaccharide (LPS)/toll-like receptor 4 signaling in mononuclear phagocytes has been explored for the treatment of inflammation and inflammation-related disorders. However, only a few key targets have been translated into clinical applications. Flavonoids, a class of ubiquitous plant secondary metabolites, possess a privileged scaffold which serves as a valuable template for designing pharmacologically active compounds directed against diseases with inflammatory components. This perspective provides a general overview of the diversity of flavonoids and their multifaceted mechanisms that interfere with LPS-induced signaling in monocytes and macrophages. Focus is placed on flavonoids targetingMD-2, IκB kinases, c-Jun N-terminal kinases, extracellular signal-regulated kinase, p38 MAPK and PI3K/Akt or modulating LPS-related gene expression. |
| first_indexed | 2025-11-15T14:28:16Z |
| format | Article |
| id | upm-116067 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T14:28:16Z |
| publishDate | 2024 |
| publisher | Newlands Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1160672025-03-19T02:43:04Z http://psasir.upm.edu.my/id/eprint/116067/ Flavonoid diversity and roles in the lipopolysaccharide-mediated inflammatory response of monocytes and macrophages Rullah, Kamal Shamsudin, Nur Farisya Koeberle, Andreas Tham, Chau Ling Targeting lipopolysaccharide (LPS)/toll-like receptor 4 signaling in mononuclear phagocytes has been explored for the treatment of inflammation and inflammation-related disorders. However, only a few key targets have been translated into clinical applications. Flavonoids, a class of ubiquitous plant secondary metabolites, possess a privileged scaffold which serves as a valuable template for designing pharmacologically active compounds directed against diseases with inflammatory components. This perspective provides a general overview of the diversity of flavonoids and their multifaceted mechanisms that interfere with LPS-induced signaling in monocytes and macrophages. Focus is placed on flavonoids targetingMD-2, IκB kinases, c-Jun N-terminal kinases, extracellular signal-regulated kinase, p38 MAPK and PI3K/Akt or modulating LPS-related gene expression. Newlands Press 2024-01-11 Article PeerReviewed Rullah, Kamal and Shamsudin, Nur Farisya and Koeberle, Andreas and Tham, Chau Ling (2024) Flavonoid diversity and roles in the lipopolysaccharide-mediated inflammatory response of monocytes and macrophages. Future Medicinal Chemistry, 16 (1). pp. 75-99. ISSN 1756-8919; eISSN: 1756-8927 https://www.tandfonline.com/doi/full/10.4155/fmc-2023-0174 10.4155/fmc-2023-0174 |
| spellingShingle | Rullah, Kamal Shamsudin, Nur Farisya Koeberle, Andreas Tham, Chau Ling Flavonoid diversity and roles in the lipopolysaccharide-mediated inflammatory response of monocytes and macrophages |
| title | Flavonoid diversity and roles in the lipopolysaccharide-mediated inflammatory response of monocytes and macrophages |
| title_full | Flavonoid diversity and roles in the lipopolysaccharide-mediated inflammatory response of monocytes and macrophages |
| title_fullStr | Flavonoid diversity and roles in the lipopolysaccharide-mediated inflammatory response of monocytes and macrophages |
| title_full_unstemmed | Flavonoid diversity and roles in the lipopolysaccharide-mediated inflammatory response of monocytes and macrophages |
| title_short | Flavonoid diversity and roles in the lipopolysaccharide-mediated inflammatory response of monocytes and macrophages |
| title_sort | flavonoid diversity and roles in the lipopolysaccharide-mediated inflammatory response of monocytes and macrophages |
| url | http://psasir.upm.edu.my/id/eprint/116067/ http://psasir.upm.edu.my/id/eprint/116067/ http://psasir.upm.edu.my/id/eprint/116067/ |