Therapeutic potential of mushrooms: a review on NF-κB modulation in chronic inflammation
Numerous mushroom species are valued not just for their flavor but also for their health advantages. Historically, these mushrooms have been utilized for medicinal purposes across different parts of the world. Research has revealed that metabolites derived from these fungi have health benefits. Rece...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/116013/ http://psasir.upm.edu.my/id/eprint/116013/1/116013.pdf |
| _version_ | 1848866911559876608 |
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| author | Amirullah, Nur Amalina Abdullah, Erlina Zainal Abidin, Nurhayati Abdullah, Noorlidah Manickam, Sivakumar |
| author_facet | Amirullah, Nur Amalina Abdullah, Erlina Zainal Abidin, Nurhayati Abdullah, Noorlidah Manickam, Sivakumar |
| author_sort | Amirullah, Nur Amalina |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Numerous mushroom species are valued not just for their flavor but also for their health advantages. Historically, these mushrooms have been utilized for medicinal purposes across different parts of the world. Research has revealed that metabolites derived from these fungi have health benefits. Recently, there has been a growing interest in understanding how these fungal metabolites provide their healing effects and comprehend their mechanisms of action. A primary focus is the nuclear factor NF-κB, a family of transcription factors essential for regulating inflammation, cell proliferation, and apoptosis. Dysregulation and abnormal activation of NF-κB proteins are associated with a variety of diseases. Various studies have investigated mushroom compounds and their impact on various conditions, including inflammatory bowel disease, gut health, metabolic syndrome, neuroinflammation, liver injury, renal and pulmonary diseases, and autoimmune disorders. This review provides a comprehensive summary of the NF-κB signaling pathway and other related inflammatory pathways. It discusses the bioactive compounds found in mushrooms, their potential to alleviate various diseases, and the specific inflammatory pathways, particularly NF-κB, that these bioactives target. |
| first_indexed | 2025-11-15T14:28:07Z |
| format | Article |
| id | upm-116013 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:28:07Z |
| publishDate | 2024 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1160132025-03-27T08:42:31Z http://psasir.upm.edu.my/id/eprint/116013/ Therapeutic potential of mushrooms: a review on NF-κB modulation in chronic inflammation Amirullah, Nur Amalina Abdullah, Erlina Zainal Abidin, Nurhayati Abdullah, Noorlidah Manickam, Sivakumar Numerous mushroom species are valued not just for their flavor but also for their health advantages. Historically, these mushrooms have been utilized for medicinal purposes across different parts of the world. Research has revealed that metabolites derived from these fungi have health benefits. Recently, there has been a growing interest in understanding how these fungal metabolites provide their healing effects and comprehend their mechanisms of action. A primary focus is the nuclear factor NF-κB, a family of transcription factors essential for regulating inflammation, cell proliferation, and apoptosis. Dysregulation and abnormal activation of NF-κB proteins are associated with a variety of diseases. Various studies have investigated mushroom compounds and their impact on various conditions, including inflammatory bowel disease, gut health, metabolic syndrome, neuroinflammation, liver injury, renal and pulmonary diseases, and autoimmune disorders. This review provides a comprehensive summary of the NF-κB signaling pathway and other related inflammatory pathways. It discusses the bioactive compounds found in mushrooms, their potential to alleviate various diseases, and the specific inflammatory pathways, particularly NF-κB, that these bioactives target. Elsevier 2024 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/116013/1/116013.pdf Amirullah, Nur Amalina and Abdullah, Erlina and Zainal Abidin, Nurhayati and Abdullah, Noorlidah and Manickam, Sivakumar (2024) Therapeutic potential of mushrooms: a review on NF-κB modulation in chronic inflammation. Food Bioscience, 62. art. no. 105059. pp. 1-25. ISSN 2212-4292; eISSN: 2212-4306 https://linkinghub.elsevier.com/retrieve/pii/S2212429224014895 10.1016/j.fbio.2024.105059 |
| spellingShingle | Amirullah, Nur Amalina Abdullah, Erlina Zainal Abidin, Nurhayati Abdullah, Noorlidah Manickam, Sivakumar Therapeutic potential of mushrooms: a review on NF-κB modulation in chronic inflammation |
| title | Therapeutic potential of mushrooms: a review on NF-κB modulation in chronic inflammation |
| title_full | Therapeutic potential of mushrooms: a review on NF-κB modulation in chronic inflammation |
| title_fullStr | Therapeutic potential of mushrooms: a review on NF-κB modulation in chronic inflammation |
| title_full_unstemmed | Therapeutic potential of mushrooms: a review on NF-κB modulation in chronic inflammation |
| title_short | Therapeutic potential of mushrooms: a review on NF-κB modulation in chronic inflammation |
| title_sort | therapeutic potential of mushrooms: a review on nf-κb modulation in chronic inflammation |
| url | http://psasir.upm.edu.my/id/eprint/116013/ http://psasir.upm.edu.my/id/eprint/116013/ http://psasir.upm.edu.my/id/eprint/116013/ http://psasir.upm.edu.my/id/eprint/116013/1/116013.pdf |