Optimizing reaction efficiency: microwave-supported synthesis of quinoxaline-based compounds
The chemistry of chloroquinoxalines has garnered significant interest owing to the potential applications of this nitrogen-containing heterocyclic class in various fields. This manuscript delves into the investigation of heteroaromatic nucleophilic substitution reactions (SNAr) involving quinoxaline...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/115971/ http://psasir.upm.edu.my/id/eprint/115971/1/115971.pdf |
| _version_ | 1848866902020980736 |
|---|---|
| author | Khatoon, Hena AbdulMalek, Emilia Munirah Mohd Faudzi, Siti Khan, Tabrej Shabbir Ahmed, Omar |
| author_facet | Khatoon, Hena AbdulMalek, Emilia Munirah Mohd Faudzi, Siti Khan, Tabrej Shabbir Ahmed, Omar |
| author_sort | Khatoon, Hena |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The chemistry of chloroquinoxalines has garnered significant interest owing to the potential applications of this nitrogen-containing heterocyclic class in various fields. This manuscript delves into the investigation of heteroaromatic nucleophilic substitution reactions (SNAr) involving quinoxaline substrates, specifically 2-chloroquinoxaline and 2-chloro-3-methylquinoxaline, in the presence of thiols (mercaptan). The documented findings present the outcome of these reactions, which proceed experimentally under mild and metal-free conditions and lead to the selective formation of mono- and di-substituted products with commendable yields. Employing microwave-assisted synthesis for the preparation of compounds 1, 4, and 5 was crucial for optimizing reaction efficiency and maximizing product formation. The experimental findings revealed an increase in the overall yield of compounds 1, 4, and 5 by approximately 15–20%, accompanied by a significant reduction in reaction time by 75%. |
| first_indexed | 2025-11-15T14:27:58Z |
| format | Article |
| id | upm-115971 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:27:58Z |
| publishDate | 2024 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1159712025-03-17T04:49:08Z http://psasir.upm.edu.my/id/eprint/115971/ Optimizing reaction efficiency: microwave-supported synthesis of quinoxaline-based compounds Khatoon, Hena AbdulMalek, Emilia Munirah Mohd Faudzi, Siti Khan, Tabrej Shabbir Ahmed, Omar The chemistry of chloroquinoxalines has garnered significant interest owing to the potential applications of this nitrogen-containing heterocyclic class in various fields. This manuscript delves into the investigation of heteroaromatic nucleophilic substitution reactions (SNAr) involving quinoxaline substrates, specifically 2-chloroquinoxaline and 2-chloro-3-methylquinoxaline, in the presence of thiols (mercaptan). The documented findings present the outcome of these reactions, which proceed experimentally under mild and metal-free conditions and lead to the selective formation of mono- and di-substituted products with commendable yields. Employing microwave-assisted synthesis for the preparation of compounds 1, 4, and 5 was crucial for optimizing reaction efficiency and maximizing product formation. The experimental findings revealed an increase in the overall yield of compounds 1, 4, and 5 by approximately 15–20%, accompanied by a significant reduction in reaction time by 75%. Elsevier 2024-01 Article PeerReviewed text en cc_by_nc_nd_4 http://psasir.upm.edu.my/id/eprint/115971/1/115971.pdf Khatoon, Hena and AbdulMalek, Emilia and Munirah Mohd Faudzi, Siti and Khan, Tabrej and Shabbir Ahmed, Omar (2024) Optimizing reaction efficiency: microwave-supported synthesis of quinoxaline-based compounds. Results in Chemistry, 7. art. no. 101438. pp. 1-5. ISSN 2211-7156 https://www.sciencedirect.com/science/article/pii/S2211715624001346?via%3Dihub 10.1016/j.rechem.2024.101438 |
| spellingShingle | Khatoon, Hena AbdulMalek, Emilia Munirah Mohd Faudzi, Siti Khan, Tabrej Shabbir Ahmed, Omar Optimizing reaction efficiency: microwave-supported synthesis of quinoxaline-based compounds |
| title | Optimizing reaction efficiency: microwave-supported synthesis of quinoxaline-based compounds |
| title_full | Optimizing reaction efficiency: microwave-supported synthesis of quinoxaline-based compounds |
| title_fullStr | Optimizing reaction efficiency: microwave-supported synthesis of quinoxaline-based compounds |
| title_full_unstemmed | Optimizing reaction efficiency: microwave-supported synthesis of quinoxaline-based compounds |
| title_short | Optimizing reaction efficiency: microwave-supported synthesis of quinoxaline-based compounds |
| title_sort | optimizing reaction efficiency: microwave-supported synthesis of quinoxaline-based compounds |
| url | http://psasir.upm.edu.my/id/eprint/115971/ http://psasir.upm.edu.my/id/eprint/115971/ http://psasir.upm.edu.my/id/eprint/115971/ http://psasir.upm.edu.my/id/eprint/115971/1/115971.pdf |