Biotechnological approaches in the production of plant secondary metabolites for treating human viral diseases: prospects and challenges
Over the last couple of decades, three highly pathogenic and deadly human coronaviruses have posed dreadful impacts on human life, namely SARS-CoV, MERS-CoV and SARS-CoV-2. In addition, many other viral diseases also affect various aspects of human well-being such as lifestyles and socio-economic co...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/115967/ http://psasir.upm.edu.my/id/eprint/115967/1/115967.pdf |
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| author | Mahmoudieh, Mohtaram Naghavi, Mohammad Reza Sobri, Zulfazli M. Mohamad Azzeme, Azzreena Abd-Aziz, Nazrin Nik Abd Rahman, Nik Mohd Afizan Alitheen, Noorjahan Banu Hussin, Yazmin Bahmanrokh, Ghazaleh Akmal Baharum, Nadiya |
| author_facet | Mahmoudieh, Mohtaram Naghavi, Mohammad Reza Sobri, Zulfazli M. Mohamad Azzeme, Azzreena Abd-Aziz, Nazrin Nik Abd Rahman, Nik Mohd Afizan Alitheen, Noorjahan Banu Hussin, Yazmin Bahmanrokh, Ghazaleh Akmal Baharum, Nadiya |
| author_sort | Mahmoudieh, Mohtaram |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Over the last couple of decades, three highly pathogenic and deadly human coronaviruses have posed dreadful impacts on human life, namely SARS-CoV, MERS-CoV and SARS-CoV-2. In addition, many other viral diseases also affect various aspects of human well-being such as lifestyles and socio-economic conditions. Therefore, research on developing antiviral drugs should be progressively carried out to rapidly prevent or reduce the severity of infection for the current and future emerging infection with pandemic potential. Conventional antiviral drugs have been associated with high cost, toxicity and resistance issues. The use of medicinal plants and their secondary metabolites (SMs) with potential anti-inflammatory properties garners attention as a safer alternative for treating viral diseases. This review discussed various plant SMs with therapeutic potential for treating viral diseases. Due to various factors including low concentrations of the phytocompounds produced, relying on natural systems for producing medically important SMs is not sustainable. Thus, several biotechnology strategies such as metabolic engineering and genetic modification, in vitro production as well as gene editing to enhance the phytochemical compounds are also highlighted. Future perspectives on the potential of plant-based antiviral drugs as well as other strategies to treat viral diseases in humans are also elaborated. Altogether, this review gives a comprehensive view of the pharmaceutical importance of plant SMs as an alternative approach against viral diseases. |
| first_indexed | 2025-11-15T14:27:58Z |
| format | Article |
| id | upm-115967 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:27:58Z |
| publishDate | 2024 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1159672025-04-10T06:40:52Z http://psasir.upm.edu.my/id/eprint/115967/ Biotechnological approaches in the production of plant secondary metabolites for treating human viral diseases: prospects and challenges Mahmoudieh, Mohtaram Naghavi, Mohammad Reza Sobri, Zulfazli M. Mohamad Azzeme, Azzreena Abd-Aziz, Nazrin Nik Abd Rahman, Nik Mohd Afizan Alitheen, Noorjahan Banu Hussin, Yazmin Bahmanrokh, Ghazaleh Akmal Baharum, Nadiya Over the last couple of decades, three highly pathogenic and deadly human coronaviruses have posed dreadful impacts on human life, namely SARS-CoV, MERS-CoV and SARS-CoV-2. In addition, many other viral diseases also affect various aspects of human well-being such as lifestyles and socio-economic conditions. Therefore, research on developing antiviral drugs should be progressively carried out to rapidly prevent or reduce the severity of infection for the current and future emerging infection with pandemic potential. Conventional antiviral drugs have been associated with high cost, toxicity and resistance issues. The use of medicinal plants and their secondary metabolites (SMs) with potential anti-inflammatory properties garners attention as a safer alternative for treating viral diseases. This review discussed various plant SMs with therapeutic potential for treating viral diseases. Due to various factors including low concentrations of the phytocompounds produced, relying on natural systems for producing medically important SMs is not sustainable. Thus, several biotechnology strategies such as metabolic engineering and genetic modification, in vitro production as well as gene editing to enhance the phytochemical compounds are also highlighted. Future perspectives on the potential of plant-based antiviral drugs as well as other strategies to treat viral diseases in humans are also elaborated. Altogether, this review gives a comprehensive view of the pharmaceutical importance of plant SMs as an alternative approach against viral diseases. Elsevier 2024-05-22 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/115967/1/115967.pdf Mahmoudieh, Mohtaram and Naghavi, Mohammad Reza and Sobri, Zulfazli M. and Mohamad Azzeme, Azzreena and Abd-Aziz, Nazrin and Nik Abd Rahman, Nik Mohd Afizan and Alitheen, Noorjahan Banu and Hussin, Yazmin and Bahmanrokh, Ghazaleh and Akmal Baharum, Nadiya (2024) Biotechnological approaches in the production of plant secondary metabolites for treating human viral diseases: prospects and challenges. Biocatalysis and Agricultural Biotechnology, 59. art. no. 103249. ISSN 1878-8181; eISSN: 1878-8181 https://linkinghub.elsevier.com/retrieve/pii/S1878818124002330 10.1016/j.bcab.2024.103249 |
| spellingShingle | Mahmoudieh, Mohtaram Naghavi, Mohammad Reza Sobri, Zulfazli M. Mohamad Azzeme, Azzreena Abd-Aziz, Nazrin Nik Abd Rahman, Nik Mohd Afizan Alitheen, Noorjahan Banu Hussin, Yazmin Bahmanrokh, Ghazaleh Akmal Baharum, Nadiya Biotechnological approaches in the production of plant secondary metabolites for treating human viral diseases: prospects and challenges |
| title | Biotechnological approaches in the production of plant secondary metabolites for treating human viral diseases: prospects and challenges |
| title_full | Biotechnological approaches in the production of plant secondary metabolites for treating human viral diseases: prospects and challenges |
| title_fullStr | Biotechnological approaches in the production of plant secondary metabolites for treating human viral diseases: prospects and challenges |
| title_full_unstemmed | Biotechnological approaches in the production of plant secondary metabolites for treating human viral diseases: prospects and challenges |
| title_short | Biotechnological approaches in the production of plant secondary metabolites for treating human viral diseases: prospects and challenges |
| title_sort | biotechnological approaches in the production of plant secondary metabolites for treating human viral diseases: prospects and challenges |
| url | http://psasir.upm.edu.my/id/eprint/115967/ http://psasir.upm.edu.my/id/eprint/115967/ http://psasir.upm.edu.my/id/eprint/115967/ http://psasir.upm.edu.my/id/eprint/115967/1/115967.pdf |