A novel chromone-based as a potential inhibitor of ULK1 that modulates autophagy and induces apoptosis in colon cancer

A novel chromone-based as a potential inhibitor of ULK1 that modulates autophagy and induces apoptosis in colon cancer

Aim: Chromones are promising for anticancer drug development. Methods & results: 12 chromone-based compounds were synthesized and tested against cancer cell lines. Compound 8 showed the highest cytotoxicity (LC50 3.2 μM) against colorectal cancer cells, surpassing 5-fluorouracil (LC50 4.2 μM). I...

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Bibliographic Details
Main Authors: Shamsudin, Nur Farisya, Leong, Sze Wei, Koeberle, Andreas, Suriya, Utid, Rungrotmongkol, Thanyada, Chia, Suet Lin, Taher, Muhammad, Haris, Muhammad Salahuddin, Alshwyeh, Hussah Abdullah, Alosaimi, Areej A, Mediani, Ahmed, Ilowefah, Muna Abdulsalam, Islami, Deri, Mohd Faudzi, Siti Munirah, Fasihi Mohd Aluwi, Mohd Fadhlizil, Wai, Lam Kok, Rullah, Kamal
Format: Article
Published: Taylor and Francis Ltd. 2024
Online Access:http://psasir.upm.edu.my/id/eprint/115904/

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