Lithium restores nuclear REST and Mitigates oxidative stress in down syndrome iPSC-Derived neurons

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Lithium restores nuclear REST and Mitigates oxidative stress in down syndrome iPSC-Derived neurons

Down syndrome (DS), caused by trisomy 21, is characterized by intellectual disability and accelerated aging, with chronic oxidative stress contributing to neurological deficits. REST (Repressor Element-1 Silencing Transcription factor) is a crucial regulator of neuronal gene expression implicated in...

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Bibliographic Details
Main Authors:	Lam, Xin-Jieh, Maniam, Sandra, Ling, King-Hwa, Cheah, Pike-See
Format:	Article
Language:	English English
Published:	Elsevier Science 2025
Subjects:	Neuroscience
Online Access:	http://psasir.upm.edu.my/id/eprint/115894/ http://psasir.upm.edu.my/id/eprint/115894/1/115894.pdf http://psasir.upm.edu.my/id/eprint/115894/2/115894-published.pdf

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