Exploring the role of Bisphenol A in obesity-driven colorectal cancer progression: network toxicology and multi-organ pathology in animal models
Bisphenol A (BPA), an endocrine disruptor, is linked to cancer progression in estrogen-responsive tissues, but its role in promoting colorectal cancer (CRC) progression in the context of obesity remains underexplored. This study examines BPA's influence on CRC in obese Sprague-Dawley rats using...
| Main Authors: | Saad, Muhamad Fikri Shazlan, Abdullah, Muhammad Nazrul Hakim, Lim, Vuanghao, Bahari, Hasnah, Khoo, Boon Yin, Tan, Jun Jie, Yong, Yoke Keong |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Academic Press
2025
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/115882/ http://psasir.upm.edu.my/id/eprint/115882/1/115882.pdf |
Similar Items
Comparing the toxicity effect induced by Bisphenol A and Bisphenol S in the zebrafish model
by: Saad, Muhamad Fikri Shazlan, et al.
Published: (2025)
by: Saad, Muhamad Fikri Shazlan, et al.
Published: (2025)
Adverse effects of bisphenol a on the liver and its underlying mechanisms: evidence from in vivo and in vitro studies
by: Abdulhameed, Al-Salihi Ahmed Rashid, et al.
Published: (2022)
by: Abdulhameed, Al-Salihi Ahmed Rashid, et al.
Published: (2022)
Bisphenol A (BPA) leading to obesity and cardiovascular complications: a compilation of current in vivo study
by: Naomi, Ruth, et al.
Published: (2022)
by: Naomi, Ruth, et al.
Published: (2022)
Bisphenol A is a carcinogen that induces lipid accumulation, peroxisome proliferator-activated receptor-γ expression and liver disease
by: Qasim Ismael, Layla, et al.
Published: (2022)
by: Qasim Ismael, Layla, et al.
Published: (2022)
Bombesin-like receptor 3 expression induced by bisphenol A is likely associated with reduced cell proliferation by inhibiting DNA synthesis and inducing inflammation in liver cells
by: Ismael, Layla Qasim, et al.
Published: (2024)
by: Ismael, Layla Qasim, et al.
Published: (2024)
Pathology of the spinal cord in progressive multiple sclerosis (primary progressive vs secondary progressive)
by: Alrawashdeh, Omar
Published: (2011)
by: Alrawashdeh, Omar
Published: (2011)
Endothelial dysfunction in obesity-induced inflammation: molecular mechanisms and clinical implications
by: Kwaifa, Ibrahim Kalle, et al.
Published: (2020)
by: Kwaifa, Ibrahim Kalle, et al.
Published: (2020)
Advanced MRI techniques in studying multiple sclerosis pathology and lesion progression
by: Elsarraj, Afaf
Published: (2016)
by: Elsarraj, Afaf
Published: (2016)
Toxicology studies in Caenorhabditis elegans
by: Budd, Chloe Denisha
Published: (2008)
by: Budd, Chloe Denisha
Published: (2008)
Toxicology and pharmacokinetics of piperaquine in mice
by: Batty, Kevin, et al.
Published: (2008)
by: Batty, Kevin, et al.
Published: (2008)
Investigation of the role of CD24 gene in the progression of colorectal cancer
by: Hakami, Zaki
Published: (2021)
by: Hakami, Zaki
Published: (2021)
E. tapos yoghurt-a view from nutritional composition and toxicological evaluation
by: Naomi, Ruth, et al.
Published: (2022)
by: Naomi, Ruth, et al.
Published: (2022)
In Vitro And In Vivo Effects Of Bisphenol A On Cell Growth, Lipid Accumulation And Inflammation In Liver Cell Line, Rat Adipose And Colorectal Tissues
by: Ismael, Ismael Layla Qasim
Published: (2024)
by: Ismael, Ismael Layla Qasim
Published: (2024)
Investigation of reproductive toxicology in piperaquine in mice
by: Batty, Kevin, et al.
Published: (2010)
by: Batty, Kevin, et al.
Published: (2010)
Network pharmacology and molecular docking analysis of active compounds in Tualang honey against atherosclerosis
by: Shamsol Azman, Ain Nabila Syahira, et al.
Published: (2023)
by: Shamsol Azman, Ain Nabila Syahira, et al.
Published: (2023)
Medicinal activities of Tualang honey: a systematic review
by: Shamsol Azman, Ain Nabila Syahira, et al.
Published: (2024)
by: Shamsol Azman, Ain Nabila Syahira, et al.
Published: (2024)
Identifying prognosis factors of pathological staging among colorectal patients using ordinal logistic regression model
by: Md Ghani, Nor Azura, et al.
by: Md Ghani, Nor Azura, et al.
Network pharmacology and molecular docking approaches of Astaxanthin (ATX) against atherosclerosis
by: Barizi, Anis Zuhaida Mamnun, et al.
Published: (2024)
by: Barizi, Anis Zuhaida Mamnun, et al.
Published: (2024)
Preliminary toxicological evaluations of Polypeptide-K isolated from Momordica Charantia in laboratory rats.
by: Abdullah, Muhammad Nazrul Hakim, et al.
Published: (2011)
by: Abdullah, Muhammad Nazrul Hakim, et al.
Published: (2011)
Loss of interleukin17RA expression is associated with tumour progression in colorectal carcinoma
by: Chai, Boon Yean, et al.
Published: (2020)
by: Chai, Boon Yean, et al.
Published: (2020)
Toxicological Impact of Agricultural Surfactants on Australian Frogs
by: Mann, Reinier Matthew
Published: (2000)
by: Mann, Reinier Matthew
Published: (2000)
Systems toxicology: real world applications and opportunities
by: Hartung, Thomas, et al.
Published: (2017)
by: Hartung, Thomas, et al.
Published: (2017)
Sunscreens: efficacy, skin penetration and toxicological aspects
by: Benson, Heather
Published: (2008)
by: Benson, Heather
Published: (2008)
Toxicological Assessment of Nannochloropsis Oculata Microalgae in Rats
by: Kafaie, Soroush
Published: (2011)
by: Kafaie, Soroush
Published: (2011)
Anti-Diabetic And Toxicological Studies Of
Gongronema Latifolium
by: Bassel Al Hindi, Bassel Al Hindi
Published: (2016)
by: Bassel Al Hindi, Bassel Al Hindi
Published: (2016)
Acute toxicological assessment of seashore mangosteen (Garcinia hombroniana) aqueous extract
by: Othman, Dyary Hiewa, et al.
Published: (2016)
by: Othman, Dyary Hiewa, et al.
Published: (2016)
Pathology
by: Behnke, Jerzy M.
Published: (1991)
by: Behnke, Jerzy M.
Published: (1991)
Investigating the role of Cut Like Homeobox 1 CUX1 in colorectal cancer progression
by: Rusnita, Dewi
Published: (2024)
by: Rusnita, Dewi
Published: (2024)
Thioredoxin system in colorectal cancer: Its role in carcinogenesis, disease progression, and response to treatment
by: Abdullah, Nurul Akmaryanti, et al.
Published: (2024)
by: Abdullah, Nurul Akmaryanti, et al.
Published: (2024)
Review of food toxicological issues associated in rubber products
by: Ng, Mei Xiang, et al.
Published: (2014)
by: Ng, Mei Xiang, et al.
Published: (2014)
Toxicological evaluation of dried Kacangma Herb (Leonurussibiricus)in rats
by: Chua, Hun Pin, et al.
Published: (2009)
by: Chua, Hun Pin, et al.
Published: (2009)
Analytical Methods for Predicted DBPs of Probable Toxicological Significance
by: Li, X., et al.
Published: (2011)
by: Li, X., et al.
Published: (2011)
Heterogeneous activation of peroxymonosulfate by amorphous boron for degradation of bisphenol S
by: Shao, P., et al.
Published: (2017)
by: Shao, P., et al.
Published: (2017)
Characterization of Bisphenol a MIP (BPA-MIP) Synthesizing
by: Shahaidah , Shariff, et al.
Published: (2014)
by: Shahaidah , Shariff, et al.
Published: (2014)
Determination of bisphenol A in water bottles
by spectrophotometric method
by: Razak, Nur Syuhada Abd
Published: (2015)
by: Razak, Nur Syuhada Abd
Published: (2015)
Phytochemical component and toxicological evaluation of purple sweet potato leaf extract in male Sprague–Dawley rats
by: Hisamuddin, Ahmad Safiyyu’d-din Bin, et al.
Published: (2023)
by: Hisamuddin, Ahmad Safiyyu’d-din Bin, et al.
Published: (2023)
A systematic comparison of microsimulation models of colorectal cancer: The role of assumptions about adenoma progression
by: Kuntz, K., et al.
Published: (2011)
by: Kuntz, K., et al.
Published: (2011)
The upstream components of the Wnt signalling pathway in the dynamic EMT and MET associated with colorectal cancer progression
by: Vincan, Elizabeth, et al.
Published: (2008)
by: Vincan, Elizabeth, et al.
Published: (2008)
Obesity and Risk of Colorectal Adenomatous Polyps: a Case-Control Study in Hospital Kuala Lumpur
by: Ramadas, Amutha, et al.
Published: (2009)
by: Ramadas, Amutha, et al.
Published: (2009)
Pathology in practice
by: Kaulfers, Carola, et al.
Published: (2017)
by: Kaulfers, Carola, et al.
Published: (2017)
Similar Items
-
Comparing the toxicity effect induced by Bisphenol A and Bisphenol S in the zebrafish model
by: Saad, Muhamad Fikri Shazlan, et al.
Published: (2025) -
Adverse effects of bisphenol a on the liver and its underlying mechanisms: evidence from in vivo and in vitro studies
by: Abdulhameed, Al-Salihi Ahmed Rashid, et al.
Published: (2022) -
Bisphenol A (BPA) leading to obesity and cardiovascular complications: a compilation of current in vivo study
by: Naomi, Ruth, et al.
Published: (2022) -
Bisphenol A is a carcinogen that induces lipid accumulation, peroxisome proliferator-activated receptor-γ expression and liver disease
by: Qasim Ismael, Layla, et al.
Published: (2022) -
Bombesin-like receptor 3 expression induced by bisphenol A is likely associated with reduced cell proliferation by inhibiting DNA synthesis and inducing inflammation in liver cells
by: Ismael, Layla Qasim, et al.
Published: (2024)