Different starting times of α-Tocopherol and γ-Tocotrienol supplementation and tumor marker enzyme activities in-the rat chemically induced with cancer
1. α-Tocopherol (α-T) and γ-tocotrienol (γ-T) were supplemented continuously for 8 weeks in the diets of normal rats and rats chemically induced with cancer using diethylnitrosamine (DEN), 2-acetylaminofluorene (AAF) and partial hepatectomy. Hepatocarcinogenesis was followed by determining the plasm...
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| Format: | Article |
| Language: | English |
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Elsevier Science
1997
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| Online Access: | http://psasir.upm.edu.my/id/eprint/115780/ http://psasir.upm.edu.my/id/eprint/115780/1/115780.pdf |
| _version_ | 1848866859117445120 |
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| author | Makpol, S. Shamaan, N.A. Jarien, Z. Md Top, A.G. Khalid, B.A.K. Wan Ngah, W.Z. |
| author_facet | Makpol, S. Shamaan, N.A. Jarien, Z. Md Top, A.G. Khalid, B.A.K. Wan Ngah, W.Z. |
| author_sort | Makpol, S. |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | 1. α-Tocopherol (α-T) and γ-tocotrienol (γ-T) were supplemented continuously for 8 weeks in the diets of normal rats and rats chemically induced with cancer using diethylnitrosamine (DEN), 2-acetylaminofluorene (AAF) and partial hepatectomy. Hepatocarcinogenesis was followed by determining the plasma γ-glutamyl-transpeptidase (GGT) and alkaline phosphatase (ALP) activities as well as placental glutathione S transferase (PGST) and GGT activities histochemically, at 4-week intervals. 2. Male Rattus norvegicus were supplemented α-T and γ-T at two different doses of 30 and 300 mg/kg diet. The supplementation was started at three different times: simultaneously with DEN administration; 4 weeks; and 8 weeks after DEN administration. 3. Elevation of plasma GGT activities and formation of PGST and GGT positive foci were attenuated significantly (P < 0.05) when α-T and γ-T were supplemented simultaneously with cancer induction. Supplementation begun 4 and 8 weeks after cancer induction did not affect plasma enzyme activities and formation of enzyme positive foci. 4. α-T was more effective than γ-T, and a lower dose of 30 mg/kg was found to be more effective in reducing the severity of hepatocarcinogenesis. |
| first_indexed | 2025-11-15T14:27:17Z |
| format | Article |
| id | upm-115780 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:27:17Z |
| publishDate | 1997 |
| publisher | Elsevier Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1157802025-07-10T08:01:56Z http://psasir.upm.edu.my/id/eprint/115780/ Different starting times of α-Tocopherol and γ-Tocotrienol supplementation and tumor marker enzyme activities in-the rat chemically induced with cancer Makpol, S. Shamaan, N.A. Jarien, Z. Md Top, A.G. Khalid, B.A.K. Wan Ngah, W.Z. 1. α-Tocopherol (α-T) and γ-tocotrienol (γ-T) were supplemented continuously for 8 weeks in the diets of normal rats and rats chemically induced with cancer using diethylnitrosamine (DEN), 2-acetylaminofluorene (AAF) and partial hepatectomy. Hepatocarcinogenesis was followed by determining the plasma γ-glutamyl-transpeptidase (GGT) and alkaline phosphatase (ALP) activities as well as placental glutathione S transferase (PGST) and GGT activities histochemically, at 4-week intervals. 2. Male Rattus norvegicus were supplemented α-T and γ-T at two different doses of 30 and 300 mg/kg diet. The supplementation was started at three different times: simultaneously with DEN administration; 4 weeks; and 8 weeks after DEN administration. 3. Elevation of plasma GGT activities and formation of PGST and GGT positive foci were attenuated significantly (P < 0.05) when α-T and γ-T were supplemented simultaneously with cancer induction. Supplementation begun 4 and 8 weeks after cancer induction did not affect plasma enzyme activities and formation of enzyme positive foci. 4. α-T was more effective than γ-T, and a lower dose of 30 mg/kg was found to be more effective in reducing the severity of hepatocarcinogenesis. Elsevier Science 1997 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/115780/1/115780.pdf Makpol, S. and Shamaan, N.A. and Jarien, Z. and Md Top, A.G. and Khalid, B.A.K. and Wan Ngah, W.Z. (1997) Different starting times of α-Tocopherol and γ-Tocotrienol supplementation and tumor marker enzyme activities in-the rat chemically induced with cancer. General Pharmacology, 28 (4). pp. 589-592. ISSN 0306-3623; eISSN: 0306-3623 https://linkinghub.elsevier.com/retrieve/pii/S030636239600239X 10.1016/S0306-3623(96)00239-X |
| spellingShingle | Makpol, S. Shamaan, N.A. Jarien, Z. Md Top, A.G. Khalid, B.A.K. Wan Ngah, W.Z. Different starting times of α-Tocopherol and γ-Tocotrienol supplementation and tumor marker enzyme activities in-the rat chemically induced with cancer |
| title | Different starting times of α-Tocopherol and γ-Tocotrienol supplementation and tumor marker enzyme activities in-the rat chemically induced with cancer |
| title_full | Different starting times of α-Tocopherol and γ-Tocotrienol supplementation and tumor marker enzyme activities in-the rat chemically induced with cancer |
| title_fullStr | Different starting times of α-Tocopherol and γ-Tocotrienol supplementation and tumor marker enzyme activities in-the rat chemically induced with cancer |
| title_full_unstemmed | Different starting times of α-Tocopherol and γ-Tocotrienol supplementation and tumor marker enzyme activities in-the rat chemically induced with cancer |
| title_short | Different starting times of α-Tocopherol and γ-Tocotrienol supplementation and tumor marker enzyme activities in-the rat chemically induced with cancer |
| title_sort | different starting times of α-tocopherol and γ-tocotrienol supplementation and tumor marker enzyme activities in-the rat chemically induced with cancer |
| url | http://psasir.upm.edu.my/id/eprint/115780/ http://psasir.upm.edu.my/id/eprint/115780/ http://psasir.upm.edu.my/id/eprint/115780/ http://psasir.upm.edu.my/id/eprint/115780/1/115780.pdf |