Hypoglycaemic effect of Stigmast-4-en-3-one, from Parkia speciosa empty pods
Oral administration of the chloroform extracts of Parkia speciosa (petai papan) empty pods to alloxan-induced diabetic rats produced a significant reduction in blood glucose levels. A hypoglycaemic assay guided extraction, isolation and structure elucidation gave stigmast-4-en-3-one. Stigmast-4-en-3...
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| Format: | Article |
| Language: | English |
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Elsevier
1995
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| Online Access: | http://psasir.upm.edu.my/id/eprint/115586/ http://psasir.upm.edu.my/id/eprint/115586/1/115586.pdf |
| _version_ | 1848866816858783744 |
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| author | Jamaluddin, Fathaiya Mohamed, Suhaila Lajis, Md.Nordin |
| author_facet | Jamaluddin, Fathaiya Mohamed, Suhaila Lajis, Md.Nordin |
| author_sort | Jamaluddin, Fathaiya |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Oral administration of the chloroform extracts of Parkia speciosa (petai papan) empty pods to alloxan-induced diabetic rats produced a significant reduction in blood glucose levels. A hypoglycaemic assay guided extraction, isolation and structure elucidation gave stigmast-4-en-3-one. Stigmast-4-en-3-one produced 84% activity at 100 mg kg-1 body weight (BW) compared to 111% activity of glibenclamide at 5 mg kg-1 BW dosages. The minimum effective dose which produced statistically significant hypoglycaemic effect was 50 mg pericarp kg-1 BW. Hypoglycaemic effect was not observed in healthy rats. Stigmast-4-en-3-one is therefore identified as a new oral hypoglycaemic agent occurring naturally in food. |
| first_indexed | 2025-11-15T14:26:37Z |
| format | Article |
| id | upm-115586 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:26:37Z |
| publishDate | 1995 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1155862025-07-08T04:40:06Z http://psasir.upm.edu.my/id/eprint/115586/ Hypoglycaemic effect of Stigmast-4-en-3-one, from Parkia speciosa empty pods Jamaluddin, Fathaiya Mohamed, Suhaila Lajis, Md.Nordin Oral administration of the chloroform extracts of Parkia speciosa (petai papan) empty pods to alloxan-induced diabetic rats produced a significant reduction in blood glucose levels. A hypoglycaemic assay guided extraction, isolation and structure elucidation gave stigmast-4-en-3-one. Stigmast-4-en-3-one produced 84% activity at 100 mg kg-1 body weight (BW) compared to 111% activity of glibenclamide at 5 mg kg-1 BW dosages. The minimum effective dose which produced statistically significant hypoglycaemic effect was 50 mg pericarp kg-1 BW. Hypoglycaemic effect was not observed in healthy rats. Stigmast-4-en-3-one is therefore identified as a new oral hypoglycaemic agent occurring naturally in food. Elsevier 1995 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/115586/1/115586.pdf Jamaluddin, Fathaiya and Mohamed, Suhaila and Lajis, Md.Nordin (1995) Hypoglycaemic effect of Stigmast-4-en-3-one, from Parkia speciosa empty pods. Food Chemistry, 54 (1). pp. 9-13. ISSN 0308-8146; eISSN: 0308-8146 https://linkinghub.elsevier.com/retrieve/pii/0308814695926565 10.1016/0308-8146(95)92656-5 |
| spellingShingle | Jamaluddin, Fathaiya Mohamed, Suhaila Lajis, Md.Nordin Hypoglycaemic effect of Stigmast-4-en-3-one, from Parkia speciosa empty pods |
| title | Hypoglycaemic effect of Stigmast-4-en-3-one, from Parkia speciosa empty pods |
| title_full | Hypoglycaemic effect of Stigmast-4-en-3-one, from Parkia speciosa empty pods |
| title_fullStr | Hypoglycaemic effect of Stigmast-4-en-3-one, from Parkia speciosa empty pods |
| title_full_unstemmed | Hypoglycaemic effect of Stigmast-4-en-3-one, from Parkia speciosa empty pods |
| title_short | Hypoglycaemic effect of Stigmast-4-en-3-one, from Parkia speciosa empty pods |
| title_sort | hypoglycaemic effect of stigmast-4-en-3-one, from parkia speciosa empty pods |
| url | http://psasir.upm.edu.my/id/eprint/115586/ http://psasir.upm.edu.my/id/eprint/115586/ http://psasir.upm.edu.my/id/eprint/115586/ http://psasir.upm.edu.my/id/eprint/115586/1/115586.pdf |