Systematic review and meta-analysis of the prognostic value of 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) and/or computed tomography (CT)-based radiomics in head and neck cancer
AIM: Radiomics involves the extraction of quantitative data from medical images to facilitate the diagnosis, prognosis, and staging of tumors. This study provides a comprehensive overview of the efficacy of radiomics in prognostic applications for head and neck cancer (HNC) in recent years. It under...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/115343/ http://psasir.upm.edu.my/id/eprint/115343/1/115343.pdf |
| _version_ | 1848866752048398336 |
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| author | Wang, B. Liu, J. Xie, J. Zhang, X. Wang, Z. Cao, Z. Wen, D. Wan Hasan, W.Z. Harun Ramli, H.R. Dong, X. |
| author_facet | Wang, B. Liu, J. Xie, J. Zhang, X. Wang, Z. Cao, Z. Wen, D. Wan Hasan, W.Z. Harun Ramli, H.R. Dong, X. |
| author_sort | Wang, B. |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | AIM: Radiomics involves the extraction of quantitative data from medical images to facilitate the diagnosis, prognosis, and staging of tumors. This study provides a comprehensive overview of the efficacy of radiomics in prognostic applications for head and neck cancer (HNC) in recent years. It undertakes a systematic review of prognostic models specific to HNC and conducts a meta-analysis to evaluate their predictive performance. MATERIALS AND METHODS: This study adhered rigorously to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for literature searches. The literature databases, including PubMed, Embase, Cochrane, and Scopus were systematically searched individually. The methodological quality of the incorporated studies underwent assessment utilizing the radiomics quality score (RQS) tool. A random-effects meta-analysis employing the Harrell concordance index (C-index) was conducted to evaluate the performance of all radiomics models. Results: Among the 388 studies retrieved, 24 studies encompassing a total of 6,978 cases were incorporated into the systematic review. Furthermore, eight studies, focusing on overall survival as an endpoint, were included in the meta-analysis. The meta-analysis revealed that the estimated random effect of the C-index for all studies utilizing radiomics alone was 0.77 (0.71–0.82), with a substantial degree of heterogeneity indicated by an I2 of 80.17%. Conclusions: Based on this review, prognostic modeling utilizing radiomics has demonstrated enhanced efficacy for head and neck cancers; however, there remains room for improvement in this approach. In the future, advancements are warranted in the integration of clinical parameters and multimodal features, balancing multicenter data, as well as in feature screening and model construction within this field. |
| first_indexed | 2025-11-15T14:25:35Z |
| format | Article |
| id | upm-115343 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:25:35Z |
| publishDate | 2024 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1153432025-04-21T02:35:41Z http://psasir.upm.edu.my/id/eprint/115343/ Systematic review and meta-analysis of the prognostic value of 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) and/or computed tomography (CT)-based radiomics in head and neck cancer Wang, B. Liu, J. Xie, J. Zhang, X. Wang, Z. Cao, Z. Wen, D. Wan Hasan, W.Z. Harun Ramli, H.R. Dong, X. AIM: Radiomics involves the extraction of quantitative data from medical images to facilitate the diagnosis, prognosis, and staging of tumors. This study provides a comprehensive overview of the efficacy of radiomics in prognostic applications for head and neck cancer (HNC) in recent years. It undertakes a systematic review of prognostic models specific to HNC and conducts a meta-analysis to evaluate their predictive performance. MATERIALS AND METHODS: This study adhered rigorously to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for literature searches. The literature databases, including PubMed, Embase, Cochrane, and Scopus were systematically searched individually. The methodological quality of the incorporated studies underwent assessment utilizing the radiomics quality score (RQS) tool. A random-effects meta-analysis employing the Harrell concordance index (C-index) was conducted to evaluate the performance of all radiomics models. Results: Among the 388 studies retrieved, 24 studies encompassing a total of 6,978 cases were incorporated into the systematic review. Furthermore, eight studies, focusing on overall survival as an endpoint, were included in the meta-analysis. The meta-analysis revealed that the estimated random effect of the C-index for all studies utilizing radiomics alone was 0.77 (0.71–0.82), with a substantial degree of heterogeneity indicated by an I2 of 80.17%. Conclusions: Based on this review, prognostic modeling utilizing radiomics has demonstrated enhanced efficacy for head and neck cancers; however, there remains room for improvement in this approach. In the future, advancements are warranted in the integration of clinical parameters and multimodal features, balancing multicenter data, as well as in feature screening and model construction within this field. Elsevier 2024-10 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/115343/1/115343.pdf Wang, B. and Liu, J. and Xie, J. and Zhang, X. and Wang, Z. and Cao, Z. and Wen, D. and Wan Hasan, W.Z. and Harun Ramli, H.R. and Dong, X. (2024) Systematic review and meta-analysis of the prognostic value of 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) and/or computed tomography (CT)-based radiomics in head and neck cancer. Clinical Radiology, 79 (10). pp. 757-772. ISSN 0009-9260; eISSN: 1365-229X https://www.sciencedirect.com/science/article/pii/S0009926024002824?via%3Dihub 10.1016/j.crad.2024.05.016 |
| spellingShingle | Wang, B. Liu, J. Xie, J. Zhang, X. Wang, Z. Cao, Z. Wen, D. Wan Hasan, W.Z. Harun Ramli, H.R. Dong, X. Systematic review and meta-analysis of the prognostic value of 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) and/or computed tomography (CT)-based radiomics in head and neck cancer |
| title | Systematic review and meta-analysis of the prognostic value of 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) and/or computed tomography (CT)-based radiomics in head and neck cancer |
| title_full | Systematic review and meta-analysis of the prognostic value of 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) and/or computed tomography (CT)-based radiomics in head and neck cancer |
| title_fullStr | Systematic review and meta-analysis of the prognostic value of 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) and/or computed tomography (CT)-based radiomics in head and neck cancer |
| title_full_unstemmed | Systematic review and meta-analysis of the prognostic value of 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) and/or computed tomography (CT)-based radiomics in head and neck cancer |
| title_short | Systematic review and meta-analysis of the prognostic value of 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) and/or computed tomography (CT)-based radiomics in head and neck cancer |
| title_sort | systematic review and meta-analysis of the prognostic value of 18f-fluorodeoxyglucose (18f-fdg) positron emission tomography (pet) and/or computed tomography (ct)-based radiomics in head and neck cancer |
| url | http://psasir.upm.edu.my/id/eprint/115343/ http://psasir.upm.edu.my/id/eprint/115343/ http://psasir.upm.edu.my/id/eprint/115343/ http://psasir.upm.edu.my/id/eprint/115343/1/115343.pdf |