Study on sentinel hosts for surveillance of future COVID-19-like outbreaks
The spread of SARS-CoV-2 to animals has the potential to evolve independently. In this study, we distinguished several sentinel animal species and genera for monitoring the re-emergence of COVID-19 or the new outbreak of COVID-19-like disease. We analyzed SARS-CoV-2 genomic data from human and nonhu...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer Science and Business Media LLC
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/115241/ http://psasir.upm.edu.my/id/eprint/115241/1/115241.pdf |
| _version_ | 1848866723911958528 |
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| author | Li, Yanjiao Hu, Jingjing Hou, Jingjing Lu, Shuiping Xiong, Jiasheng Wang, Yuxi Sun, Zhong Chen, Weijie Pan, Yue Thilakavathy, Karuppiah Feng, Yi Jiang, Qingwu Wang, Weibing Xiong, Chenglong |
| author_facet | Li, Yanjiao Hu, Jingjing Hou, Jingjing Lu, Shuiping Xiong, Jiasheng Wang, Yuxi Sun, Zhong Chen, Weijie Pan, Yue Thilakavathy, Karuppiah Feng, Yi Jiang, Qingwu Wang, Weibing Xiong, Chenglong |
| author_sort | Li, Yanjiao |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The spread of SARS-CoV-2 to animals has the potential to evolve independently. In this study, we distinguished several sentinel animal species and genera for monitoring the re-emergence of COVID-19 or the new outbreak of COVID-19-like disease. We analyzed SARS-CoV-2 genomic data from human and nonhuman mammals in the taxonomic hierarchies of species, genus, family and order of their host. We find that SARS-CoV-2 carried by domestic dog (Canis lupus familiaris), domestic cat (Felis catus), mink (Neovison vison), and white-tailed deer (Odocoileus virginianus) cluster closely to human-origin viruses and show no differences in the majority of amino acids, but have the most positively selected sites and should be monitored to prevent the re-emergence of COVID-19 caused by novel variants of SARS-CoV-2. Viruses from the genera Panthera (especially lion (Panthera leo)), Manis and Rhinolophus differ significantly from human-origin viruses, and long-term surveillance should be undertaken to prevent the future COVID-19-like outbreaks. Investigation of the variation dynamics of sites 142, 501, 655, 681 and 950 within the S protein may be necessary to predict the novel animal SARS-CoV-2 variants. |
| first_indexed | 2025-11-15T14:25:08Z |
| format | Article |
| id | upm-115241 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:25:08Z |
| publishDate | 2024 |
| publisher | Springer Science and Business Media LLC |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1152412025-02-26T08:31:01Z http://psasir.upm.edu.my/id/eprint/115241/ Study on sentinel hosts for surveillance of future COVID-19-like outbreaks Li, Yanjiao Hu, Jingjing Hou, Jingjing Lu, Shuiping Xiong, Jiasheng Wang, Yuxi Sun, Zhong Chen, Weijie Pan, Yue Thilakavathy, Karuppiah Feng, Yi Jiang, Qingwu Wang, Weibing Xiong, Chenglong The spread of SARS-CoV-2 to animals has the potential to evolve independently. In this study, we distinguished several sentinel animal species and genera for monitoring the re-emergence of COVID-19 or the new outbreak of COVID-19-like disease. We analyzed SARS-CoV-2 genomic data from human and nonhuman mammals in the taxonomic hierarchies of species, genus, family and order of their host. We find that SARS-CoV-2 carried by domestic dog (Canis lupus familiaris), domestic cat (Felis catus), mink (Neovison vison), and white-tailed deer (Odocoileus virginianus) cluster closely to human-origin viruses and show no differences in the majority of amino acids, but have the most positively selected sites and should be monitored to prevent the re-emergence of COVID-19 caused by novel variants of SARS-CoV-2. Viruses from the genera Panthera (especially lion (Panthera leo)), Manis and Rhinolophus differ significantly from human-origin viruses, and long-term surveillance should be undertaken to prevent the future COVID-19-like outbreaks. Investigation of the variation dynamics of sites 142, 501, 655, 681 and 950 within the S protein may be necessary to predict the novel animal SARS-CoV-2 variants. Springer Science and Business Media LLC 2024 Article PeerReviewed text en cc_by_4 http://psasir.upm.edu.my/id/eprint/115241/1/115241.pdf Li, Yanjiao and Hu, Jingjing and Hou, Jingjing and Lu, Shuiping and Xiong, Jiasheng and Wang, Yuxi and Sun, Zhong and Chen, Weijie and Pan, Yue and Thilakavathy, Karuppiah and Feng, Yi and Jiang, Qingwu and Wang, Weibing and Xiong, Chenglong (2024) Study on sentinel hosts for surveillance of future COVID-19-like outbreaks. Scientific Reports, 14 (1). art. no. 24595. pp. 1-11. ISSN 2045-2322 https://www.nature.com/articles/s41598-024-76506-7?error=cookies_not_supported&code=9c4338ff-0201-469f-8b9b-7e6ec6f99414 10.1038/s41598-024-76506-7 |
| spellingShingle | Li, Yanjiao Hu, Jingjing Hou, Jingjing Lu, Shuiping Xiong, Jiasheng Wang, Yuxi Sun, Zhong Chen, Weijie Pan, Yue Thilakavathy, Karuppiah Feng, Yi Jiang, Qingwu Wang, Weibing Xiong, Chenglong Study on sentinel hosts for surveillance of future COVID-19-like outbreaks |
| title | Study on sentinel hosts for surveillance of future COVID-19-like outbreaks |
| title_full | Study on sentinel hosts for surveillance of future COVID-19-like outbreaks |
| title_fullStr | Study on sentinel hosts for surveillance of future COVID-19-like outbreaks |
| title_full_unstemmed | Study on sentinel hosts for surveillance of future COVID-19-like outbreaks |
| title_short | Study on sentinel hosts for surveillance of future COVID-19-like outbreaks |
| title_sort | study on sentinel hosts for surveillance of future covid-19-like outbreaks |
| url | http://psasir.upm.edu.my/id/eprint/115241/ http://psasir.upm.edu.my/id/eprint/115241/ http://psasir.upm.edu.my/id/eprint/115241/ http://psasir.upm.edu.my/id/eprint/115241/1/115241.pdf |