Chromosomal and cellular therapeutic approaches for Down syndrome: a research update

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Chromosomal and cellular therapeutic approaches for Down syndrome: a research update

In individuals with Down syndrome (DS), an additional HSA21 chromosome copy leads to the overexpression of a myriad of HSA21 genes, disrupting the transcription of the entire genome. This dysregulation in transcription and post-transcriptional modifications contributes to abnormal phenotypes across...

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Bibliographic Details
Main Authors:	Huang, Tan, Fakurazi, Sharida, Cheah, Pike-See, Ling, King-Hwa
Format:	Article
Language:	English
Published:	Elsevier 2024
Online Access:	http://psasir.upm.edu.my/id/eprint/115209/ http://psasir.upm.edu.my/id/eprint/115209/1/115209.pdf

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