Genetically engineered microalgae for enhanced bioactive compounds
Microalgae are naturally rich in carbohydrates, lipids, proteins, pigments, minerals, and vitamins. These metabolites make them a renewable and sustainable source of bioactive compounds in nutraceuticals, food, feed for aquaculture, and biofuels. Genetic engineering of the existing strains remains c...
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| Format: | Article |
| Language: | English |
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Springer Nature
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/115027/ http://psasir.upm.edu.my/id/eprint/115027/1/115027.pdf |
| _version_ | 1848866664938995712 |
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| author | Ahmad Kamal, Ahmad Hanafi Mohd Hamidi, Nor Farahdevah Zakaria, Muhammad Faiz Ahmad, Aziz Harun, Mohd Razif Chandra Segaran, Thirukanthan Jusoh, Malinna |
| author_facet | Ahmad Kamal, Ahmad Hanafi Mohd Hamidi, Nor Farahdevah Zakaria, Muhammad Faiz Ahmad, Aziz Harun, Mohd Razif Chandra Segaran, Thirukanthan Jusoh, Malinna |
| author_sort | Ahmad Kamal, Ahmad Hanafi |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Microalgae are naturally rich in carbohydrates, lipids, proteins, pigments, minerals, and vitamins. These metabolites make them a renewable and sustainable source of bioactive compounds in nutraceuticals, food, feed for aquaculture, and biofuels. Genetic engineering of the existing strains remains crucial in utilising and upscaling microalgae-based biorefineries. CRISPR/Cas9, TALENs, ZFNs, and genetic transformation are the established tools utilised in microalgae genetic engineering. The common genetic transformation methods include electroporation, particle bombardment (biolistics), glass-bead agitation, and Agrobacterium-mediated transformation. Expression vectors and promoters are the prerequisites in genetic engineering. The present accessibility of genome sequences and omics datasets from a diverse array of microalgae species holds promise for catalyzing strategic progress in developing a superior microalgae strain suitable for numerous applications. This paper describes the genetic engineering to enhance microalgae biomass and metabolite production, particularly lipids. The advantages and precautions to fulfil the future application of genetically engineered microalgae are also reviewed and addressed. |
| first_indexed | 2025-11-15T14:24:12Z |
| format | Article |
| id | upm-115027 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:24:12Z |
| publishDate | 2024 |
| publisher | Springer Nature |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1150272025-02-17T08:56:10Z http://psasir.upm.edu.my/id/eprint/115027/ Genetically engineered microalgae for enhanced bioactive compounds Ahmad Kamal, Ahmad Hanafi Mohd Hamidi, Nor Farahdevah Zakaria, Muhammad Faiz Ahmad, Aziz Harun, Mohd Razif Chandra Segaran, Thirukanthan Jusoh, Malinna Microalgae are naturally rich in carbohydrates, lipids, proteins, pigments, minerals, and vitamins. These metabolites make them a renewable and sustainable source of bioactive compounds in nutraceuticals, food, feed for aquaculture, and biofuels. Genetic engineering of the existing strains remains crucial in utilising and upscaling microalgae-based biorefineries. CRISPR/Cas9, TALENs, ZFNs, and genetic transformation are the established tools utilised in microalgae genetic engineering. The common genetic transformation methods include electroporation, particle bombardment (biolistics), glass-bead agitation, and Agrobacterium-mediated transformation. Expression vectors and promoters are the prerequisites in genetic engineering. The present accessibility of genome sequences and omics datasets from a diverse array of microalgae species holds promise for catalyzing strategic progress in developing a superior microalgae strain suitable for numerous applications. This paper describes the genetic engineering to enhance microalgae biomass and metabolite production, particularly lipids. The advantages and precautions to fulfil the future application of genetically engineered microalgae are also reviewed and addressed. Springer Nature 2024 Article PeerReviewed text en cc_by_nc_nd_4 http://psasir.upm.edu.my/id/eprint/115027/1/115027.pdf Ahmad Kamal, Ahmad Hanafi and Mohd Hamidi, Nor Farahdevah and Zakaria, Muhammad Faiz and Ahmad, Aziz and Harun, Mohd Razif and Chandra Segaran, Thirukanthan and Jusoh, Malinna (2024) Genetically engineered microalgae for enhanced bioactive compounds. Discover Applied Sciences, 6 (9). art. no. 482. ISSN 3004-9261; eISSN: 3004-9261 https://link.springer.com/article/10.1007/s42452-024-06116-5?error=cookies_not_supported&code=3dbd0ed2-5b4a-4a13-9624-e9f4c0e595f8 10.1007/s42452-024-06116-5 |
| spellingShingle | Ahmad Kamal, Ahmad Hanafi Mohd Hamidi, Nor Farahdevah Zakaria, Muhammad Faiz Ahmad, Aziz Harun, Mohd Razif Chandra Segaran, Thirukanthan Jusoh, Malinna Genetically engineered microalgae for enhanced bioactive compounds |
| title | Genetically engineered microalgae for enhanced bioactive compounds |
| title_full | Genetically engineered microalgae for enhanced bioactive compounds |
| title_fullStr | Genetically engineered microalgae for enhanced bioactive compounds |
| title_full_unstemmed | Genetically engineered microalgae for enhanced bioactive compounds |
| title_short | Genetically engineered microalgae for enhanced bioactive compounds |
| title_sort | genetically engineered microalgae for enhanced bioactive compounds |
| url | http://psasir.upm.edu.my/id/eprint/115027/ http://psasir.upm.edu.my/id/eprint/115027/ http://psasir.upm.edu.my/id/eprint/115027/ http://psasir.upm.edu.my/id/eprint/115027/1/115027.pdf |