Immuno-protective effect of commercial IBD vaccines against emerging novel variant infectious bursal disease virus in specific-pathogen-free chickens
Importance: Infectious bursal disease (IBD) is an important viral poultry disease that vaccination can control. Objective: This study examined the immune protection of immune-complex (Vaccine A) and attenuated live (Vaccine B) IBD vaccines in specific-pathogen-free (SPF) chickens against a novel Mal...
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| Format: | Article |
| Language: | English |
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Korean Society of Veterinary Science
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/114927/ http://psasir.upm.edu.my/id/eprint/114927/1/114927.pdf |
| _version_ | 1848866636569772032 |
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| author | Aliyu, Hayatuddeen Bako Hamisu, Tasiu Mallam Hair-Bejo, Mohd Omar, Abdul Rahman Ideris, Aini |
| author_facet | Aliyu, Hayatuddeen Bako Hamisu, Tasiu Mallam Hair-Bejo, Mohd Omar, Abdul Rahman Ideris, Aini |
| author_sort | Aliyu, Hayatuddeen Bako |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Importance: Infectious bursal disease (IBD) is an important viral poultry disease that vaccination can control. Objective: This study examined the immune protection of immune-complex (Vaccine A) and attenuated live (Vaccine B) IBD vaccines in specific-pathogen-free (SPF) chickens against a novel Malaysian variant IBD virus (vaIBDV) challenge. Methods: One-day-old (n =75) SPF chickens were divided randomly into the following three groups of 25 chicks each: Control, Vaccine A, and Vaccine B groups. The vaIBDV strain, UPM1432/2019, was used for the challenge at 21 and 28days post-vaccination (dpv). Five birds from unchallenged and challenged groups were sacrificed seven days post-challenge, and blood, bursa, spleen, and cloacal swabs were collected. The IBD antibodies (Abs), lymphoid lesions, and viral load were determined. Results: The UPM1432/2019 virus induced bursal damage in vaccinated SPF chickens despite Ab titers. The mean Ab titers of the Vaccine A challenged group were significantly lower (p < 0.002) than in the unchallenged group at 28 dpv. The bursal indices of the vaccinated unchallenged groups did not differ significantly from those of the vaccinated challenged groups (p = 0.94). Microscopically, the bursae of the challenged groups showed significant atrophy. The bursal lesion score was higher (p < 0.05) in the control and Vaccine B challenged groups than the Vaccine A challenged group. The challenged group had a higher viral load than the vaccinated groups (p < 0.001). Conclusions and Relevance: Neither vaccine fully protected against a vaIBDV challenge, highlighting the limitations of current vaccines and the need for further research. |
| first_indexed | 2025-11-15T14:23:45Z |
| format | Article |
| id | upm-114927 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:23:45Z |
| publishDate | 2024 |
| publisher | Korean Society of Veterinary Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1149272025-02-12T02:32:26Z http://psasir.upm.edu.my/id/eprint/114927/ Immuno-protective effect of commercial IBD vaccines against emerging novel variant infectious bursal disease virus in specific-pathogen-free chickens Aliyu, Hayatuddeen Bako Hamisu, Tasiu Mallam Hair-Bejo, Mohd Omar, Abdul Rahman Ideris, Aini Importance: Infectious bursal disease (IBD) is an important viral poultry disease that vaccination can control. Objective: This study examined the immune protection of immune-complex (Vaccine A) and attenuated live (Vaccine B) IBD vaccines in specific-pathogen-free (SPF) chickens against a novel Malaysian variant IBD virus (vaIBDV) challenge. Methods: One-day-old (n =75) SPF chickens were divided randomly into the following three groups of 25 chicks each: Control, Vaccine A, and Vaccine B groups. The vaIBDV strain, UPM1432/2019, was used for the challenge at 21 and 28days post-vaccination (dpv). Five birds from unchallenged and challenged groups were sacrificed seven days post-challenge, and blood, bursa, spleen, and cloacal swabs were collected. The IBD antibodies (Abs), lymphoid lesions, and viral load were determined. Results: The UPM1432/2019 virus induced bursal damage in vaccinated SPF chickens despite Ab titers. The mean Ab titers of the Vaccine A challenged group were significantly lower (p < 0.002) than in the unchallenged group at 28 dpv. The bursal indices of the vaccinated unchallenged groups did not differ significantly from those of the vaccinated challenged groups (p = 0.94). Microscopically, the bursae of the challenged groups showed significant atrophy. The bursal lesion score was higher (p < 0.05) in the control and Vaccine B challenged groups than the Vaccine A challenged group. The challenged group had a higher viral load than the vaccinated groups (p < 0.001). Conclusions and Relevance: Neither vaccine fully protected against a vaIBDV challenge, highlighting the limitations of current vaccines and the need for further research. Korean Society of Veterinary Science 2024-09-05 Article PeerReviewed text en cc_by_nc_4 http://psasir.upm.edu.my/id/eprint/114927/1/114927.pdf Aliyu, Hayatuddeen Bako and Hamisu, Tasiu Mallam and Hair-Bejo, Mohd and Omar, Abdul Rahman and Ideris, Aini (2024) Immuno-protective effect of commercial IBD vaccines against emerging novel variant infectious bursal disease virus in specific-pathogen-free chickens. Journal of Veterinary Science, 25 (5). art. no. e70. ISSN 1229-845X; eISSN: 1976-555X https://vetsci.org/DOIx.php?id=10.4142/jvs.23297 10.4142/jvs.23297 |
| spellingShingle | Aliyu, Hayatuddeen Bako Hamisu, Tasiu Mallam Hair-Bejo, Mohd Omar, Abdul Rahman Ideris, Aini Immuno-protective effect of commercial IBD vaccines against emerging novel variant infectious bursal disease virus in specific-pathogen-free chickens |
| title | Immuno-protective effect of commercial IBD vaccines against emerging novel variant infectious bursal disease virus in specific-pathogen-free chickens |
| title_full | Immuno-protective effect of commercial IBD vaccines against emerging novel variant infectious bursal disease virus in specific-pathogen-free chickens |
| title_fullStr | Immuno-protective effect of commercial IBD vaccines against emerging novel variant infectious bursal disease virus in specific-pathogen-free chickens |
| title_full_unstemmed | Immuno-protective effect of commercial IBD vaccines against emerging novel variant infectious bursal disease virus in specific-pathogen-free chickens |
| title_short | Immuno-protective effect of commercial IBD vaccines against emerging novel variant infectious bursal disease virus in specific-pathogen-free chickens |
| title_sort | immuno-protective effect of commercial ibd vaccines against emerging novel variant infectious bursal disease virus in specific-pathogen-free chickens |
| url | http://psasir.upm.edu.my/id/eprint/114927/ http://psasir.upm.edu.my/id/eprint/114927/ http://psasir.upm.edu.my/id/eprint/114927/ http://psasir.upm.edu.my/id/eprint/114927/1/114927.pdf |