Alkylglycerol: not abundant but promising functional lipid
Background: Alkylglycerols are a special class of functional ether lipids. In recent years, these functional lipids have garnered significant attention due to their unique biological functions, such as anti-obesity, anti-cancer, anti-inflammatory, and anti-cardiovascular disease properties. Scope an...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/114925/ http://psasir.upm.edu.my/id/eprint/114925/1/114925.pdf |
| _version_ | 1848866636029755392 |
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| author | Wang, Hai-Long Tan, Chin Ping Liu, Yuanfa Xu, Yong-Jiang |
| author_facet | Wang, Hai-Long Tan, Chin Ping Liu, Yuanfa Xu, Yong-Jiang |
| author_sort | Wang, Hai-Long |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Background: Alkylglycerols are a special class of functional ether lipids. In recent years, these functional lipids have garnered significant attention due to their unique biological functions, such as anti-obesity, anti-cancer, anti-inflammatory, and anti-cardiovascular disease properties. Scope and approach: This article summarizes the natural sources, analytical methods, digestion and absorption properties, endogenous occurrence, and nutritional effects of alkylglycerols. It intends to provide a compre hensive and up-to-date review of the distribution and function of alkylglycerols and the problems encountered in current research. Key findings and conclusions: Marine organisms, especially cartilaginous fish, are the main source of alkylgly cerols, whereas terricolous plants remain to be further investigated for the presence of alkylglycerols. Mean while, microorganisms are a novel and valuable source of alkylglycerols. Besides, processing and storage treatments can also affect the molecular species of esterified alkylglycerols and plasmalogens in various foods, especially milk. GC-MS and LC-MS are the commonly used methods for the analysis of alkylglycerols in food and biological samples. Notably, the bioavailability of dietary alkylglycerols exhibits a negative correlation with the expression levels of alkylglycerol monooxygenase in intestinal epithelial cells. Dietary intake of alkylglycerols could greatly enrich endogenous ether lipid levels in various peripheral tissues (such as those of plasmalogens), which in turn could contribute to the prevention of various diseases. However, the causal relationship between decreased or increased levels of endogenous ether lipids and the development of various diseases remains un clear. In conclusion, alkylglycerols are a promising class of functional lipids, but further studies are required to elucidate the existing problems. |
| first_indexed | 2025-11-15T14:23:45Z |
| format | Article |
| id | upm-114925 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:23:45Z |
| publishDate | 2024 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1149252025-02-12T02:05:56Z http://psasir.upm.edu.my/id/eprint/114925/ Alkylglycerol: not abundant but promising functional lipid Wang, Hai-Long Tan, Chin Ping Liu, Yuanfa Xu, Yong-Jiang Background: Alkylglycerols are a special class of functional ether lipids. In recent years, these functional lipids have garnered significant attention due to their unique biological functions, such as anti-obesity, anti-cancer, anti-inflammatory, and anti-cardiovascular disease properties. Scope and approach: This article summarizes the natural sources, analytical methods, digestion and absorption properties, endogenous occurrence, and nutritional effects of alkylglycerols. It intends to provide a compre hensive and up-to-date review of the distribution and function of alkylglycerols and the problems encountered in current research. Key findings and conclusions: Marine organisms, especially cartilaginous fish, are the main source of alkylgly cerols, whereas terricolous plants remain to be further investigated for the presence of alkylglycerols. Mean while, microorganisms are a novel and valuable source of alkylglycerols. Besides, processing and storage treatments can also affect the molecular species of esterified alkylglycerols and plasmalogens in various foods, especially milk. GC-MS and LC-MS are the commonly used methods for the analysis of alkylglycerols in food and biological samples. Notably, the bioavailability of dietary alkylglycerols exhibits a negative correlation with the expression levels of alkylglycerol monooxygenase in intestinal epithelial cells. Dietary intake of alkylglycerols could greatly enrich endogenous ether lipid levels in various peripheral tissues (such as those of plasmalogens), which in turn could contribute to the prevention of various diseases. However, the causal relationship between decreased or increased levels of endogenous ether lipids and the development of various diseases remains un clear. In conclusion, alkylglycerols are a promising class of functional lipids, but further studies are required to elucidate the existing problems. Elsevier 2024 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/114925/1/114925.pdf Wang, Hai-Long and Tan, Chin Ping and Liu, Yuanfa and Xu, Yong-Jiang (2024) Alkylglycerol: not abundant but promising functional lipid. Trends in Food Science and Technology, 153. art. no. 104701. pp. 1-17. ISSN 0924-2244; eISSN: 0924-2244 https://www.sciencedirect.com/science/article/pii/S0924224424003777 10.1016/j.tifs.2024.104701 |
| spellingShingle | Wang, Hai-Long Tan, Chin Ping Liu, Yuanfa Xu, Yong-Jiang Alkylglycerol: not abundant but promising functional lipid |
| title | Alkylglycerol: not abundant but promising functional lipid |
| title_full | Alkylglycerol: not abundant but promising functional lipid |
| title_fullStr | Alkylglycerol: not abundant but promising functional lipid |
| title_full_unstemmed | Alkylglycerol: not abundant but promising functional lipid |
| title_short | Alkylglycerol: not abundant but promising functional lipid |
| title_sort | alkylglycerol: not abundant but promising functional lipid |
| url | http://psasir.upm.edu.my/id/eprint/114925/ http://psasir.upm.edu.my/id/eprint/114925/ http://psasir.upm.edu.my/id/eprint/114925/ http://psasir.upm.edu.my/id/eprint/114925/1/114925.pdf |