Unveiling the potential of prostate-specific membrane antigen for precision diagnosis and therapy of prostate cancer: a radiopharmaceutical perspective
Prostate-specific membrane antigen (PSMA) has proven to be an important target for diagnostic imaging in prostate cancer. As PSMA is overexpressed on the surface of prostate cancer cells, numerous targeted PSMA ligands have been developed. The emergence of PSMA targeting based on small molecules, su...
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Sains Malaysia
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/114866/ http://psasir.upm.edu.my/id/eprint/114866/1/114866.pdf |
| _version_ | 1848866618827866112 |
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| author | Hassan, Hishar Othman, Muhamad Faiz Ashhar, Zarif Naim Abdul Razak, Hairil Rashmizal Ahmad Saad, Fathinul Fikri |
| author_facet | Hassan, Hishar Othman, Muhamad Faiz Ashhar, Zarif Naim Abdul Razak, Hairil Rashmizal Ahmad Saad, Fathinul Fikri |
| author_sort | Hassan, Hishar |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Prostate-specific membrane antigen (PSMA) has proven to be an important target for diagnostic imaging in prostate cancer. As PSMA is overexpressed on the surface of prostate cancer cells, numerous targeted PSMA ligands have been developed. The emergence of PSMA targeting based on small molecules, such as the PSMA-11 ligand (or PSMA-HBED-CC), has led to breakthroughs, such as [68Ga]Ga-PSMA-11, for positron emission tomography (PET) imaging of biochemically recurrent or metastatic castration-resistant prostate cancer (mCRPC). In addition, the recent approval of [177Lu]Lu-PSMA-617 for the treatment of adult patients with PSMA-positive mCRPC represents an important milestone in prostate cancer therapy. These advances underscore the growing confidence in the use of PSMA-targeted radiopharmaceuticals for the diagnosis and treatment of prostate cancer patients. PSMA-targeted radiopharmaceuticals have been shown to significantly impact treatment planning and clinical decision-making and facilitate the customisation of treatment regimens. |
| first_indexed | 2025-11-15T14:23:28Z |
| format | Article |
| id | upm-114866 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:23:28Z |
| publishDate | 2024 |
| publisher | Penerbit Universiti Sains Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1148662025-03-12T03:59:35Z http://psasir.upm.edu.my/id/eprint/114866/ Unveiling the potential of prostate-specific membrane antigen for precision diagnosis and therapy of prostate cancer: a radiopharmaceutical perspective Hassan, Hishar Othman, Muhamad Faiz Ashhar, Zarif Naim Abdul Razak, Hairil Rashmizal Ahmad Saad, Fathinul Fikri Prostate-specific membrane antigen (PSMA) has proven to be an important target for diagnostic imaging in prostate cancer. As PSMA is overexpressed on the surface of prostate cancer cells, numerous targeted PSMA ligands have been developed. The emergence of PSMA targeting based on small molecules, such as the PSMA-11 ligand (or PSMA-HBED-CC), has led to breakthroughs, such as [68Ga]Ga-PSMA-11, for positron emission tomography (PET) imaging of biochemically recurrent or metastatic castration-resistant prostate cancer (mCRPC). In addition, the recent approval of [177Lu]Lu-PSMA-617 for the treatment of adult patients with PSMA-positive mCRPC represents an important milestone in prostate cancer therapy. These advances underscore the growing confidence in the use of PSMA-targeted radiopharmaceuticals for the diagnosis and treatment of prostate cancer patients. PSMA-targeted radiopharmaceuticals have been shown to significantly impact treatment planning and clinical decision-making and facilitate the customisation of treatment regimens. Penerbit Universiti Sains Malaysia 2024-08-27 Article PeerReviewed text en cc_by_4 http://psasir.upm.edu.my/id/eprint/114866/1/114866.pdf Hassan, Hishar and Othman, Muhamad Faiz and Ashhar, Zarif Naim and Abdul Razak, Hairil Rashmizal and Ahmad Saad, Fathinul Fikri (2024) Unveiling the potential of prostate-specific membrane antigen for precision diagnosis and therapy of prostate cancer: a radiopharmaceutical perspective. Malaysian Journal of Medical Sciences, 31 (4). pp. 213-217. ISSN 1394-195X; eISSN: 2180-4303 http://www.mjms.usm.my/MJMS31042024/MJMS31042024_17.pdf 10.21315/mjms2024.31.4.17 |
| spellingShingle | Hassan, Hishar Othman, Muhamad Faiz Ashhar, Zarif Naim Abdul Razak, Hairil Rashmizal Ahmad Saad, Fathinul Fikri Unveiling the potential of prostate-specific membrane antigen for precision diagnosis and therapy of prostate cancer: a radiopharmaceutical perspective |
| title | Unveiling the potential of prostate-specific membrane antigen for precision diagnosis and therapy of prostate cancer: a radiopharmaceutical perspective |
| title_full | Unveiling the potential of prostate-specific membrane antigen for precision diagnosis and therapy of prostate cancer: a radiopharmaceutical perspective |
| title_fullStr | Unveiling the potential of prostate-specific membrane antigen for precision diagnosis and therapy of prostate cancer: a radiopharmaceutical perspective |
| title_full_unstemmed | Unveiling the potential of prostate-specific membrane antigen for precision diagnosis and therapy of prostate cancer: a radiopharmaceutical perspective |
| title_short | Unveiling the potential of prostate-specific membrane antigen for precision diagnosis and therapy of prostate cancer: a radiopharmaceutical perspective |
| title_sort | unveiling the potential of prostate-specific membrane antigen for precision diagnosis and therapy of prostate cancer: a radiopharmaceutical perspective |
| url | http://psasir.upm.edu.my/id/eprint/114866/ http://psasir.upm.edu.my/id/eprint/114866/ http://psasir.upm.edu.my/id/eprint/114866/ http://psasir.upm.edu.my/id/eprint/114866/1/114866.pdf |