Effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene
The effect of tocotrienol on the activities of glutathione S-transferases (GSTs), glutathione reductase (GR) and glutathione peroxidase (GPx) in rats given 2-acetylaminofluorene (AAF) was investigated over a 20 week period. Liver and kidney GST and liver GR activities were significantly increased af...
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| Format: | Article |
| Language: | English |
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1993
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| Online Access: | http://psasir.upm.edu.my/id/eprint/114818/ http://psasir.upm.edu.my/id/eprint/114818/1/114818.pdf |
| _version_ | 1848866604445597696 |
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| author | Shamaan, Nor Aripin Wan Ngah, Wan Zurinah Ibrahim, Rusli Jarien, Zanariah |
| author_facet | Shamaan, Nor Aripin Wan Ngah, Wan Zurinah Ibrahim, Rusli Jarien, Zanariah |
| author_sort | Shamaan, Nor Aripin |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The effect of tocotrienol on the activities of glutathione S-transferases (GSTs), glutathione reductase (GR) and glutathione peroxidase (GPx) in rats given 2-acetylaminofluorene (AAF) was investigated over a 20 week period. Liver and kidney GST and liver GR activities were significantly increased after AAF administration. Kidney GPx activities were significantly affected; activity assayed with cumene hydroperoxide (cu-OOH) was increased but activity assayed with H2O2 was reduced. Supplementation of the diet with tocotrienol in the AAF-treated rats reduced the increase in enzyme activities. Tocotrienol on its own had no effect on the enzyme activities. © 1993. |
| first_indexed | 2025-11-15T14:23:15Z |
| format | Article |
| id | upm-114818 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:23:15Z |
| publishDate | 1993 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1148182025-02-03T06:31:37Z http://psasir.upm.edu.my/id/eprint/114818/ Effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene Shamaan, Nor Aripin Wan Ngah, Wan Zurinah Ibrahim, Rusli Jarien, Zanariah The effect of tocotrienol on the activities of glutathione S-transferases (GSTs), glutathione reductase (GR) and glutathione peroxidase (GPx) in rats given 2-acetylaminofluorene (AAF) was investigated over a 20 week period. Liver and kidney GST and liver GR activities were significantly increased after AAF administration. Kidney GPx activities were significantly affected; activity assayed with cumene hydroperoxide (cu-OOH) was increased but activity assayed with H2O2 was reduced. Supplementation of the diet with tocotrienol in the AAF-treated rats reduced the increase in enzyme activities. Tocotrienol on its own had no effect on the enzyme activities. © 1993. 1993 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/114818/1/114818.pdf Shamaan, Nor Aripin and Wan Ngah, Wan Zurinah and Ibrahim, Rusli and Jarien, Zanariah (1993) Effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene. Biochemical Pharmacology, 45 (7). pp. 1517-1519. ISSN 0006-2952; eISSN: 0006-2952 https://linkinghub.elsevier.com/retrieve/pii/000629529390052X 10.1016/0006-2952(93)90052-X |
| spellingShingle | Shamaan, Nor Aripin Wan Ngah, Wan Zurinah Ibrahim, Rusli Jarien, Zanariah Effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene |
| title | Effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene |
| title_full | Effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene |
| title_fullStr | Effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene |
| title_full_unstemmed | Effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene |
| title_short | Effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene |
| title_sort | effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene |
| url | http://psasir.upm.edu.my/id/eprint/114818/ http://psasir.upm.edu.my/id/eprint/114818/ http://psasir.upm.edu.my/id/eprint/114818/ http://psasir.upm.edu.my/id/eprint/114818/1/114818.pdf |