Work intensity and fat mass percentage are associated with asymptomatic morphometric vertebral fractures in knee osteoarthritis patients: a cross-sectional study
Knee osteoarthritis (OA) is a common condition with a prevalence of 365 million individuals globally, and it is an independent risk factor for falls and fractures, notably asymptomatic morphometric vertebral fractures (AMVF). The high prevalence of knee OA, the severity of AMVF, and their combined i...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/114641/ http://psasir.upm.edu.my/id/eprint/114641/1/114641.pdf |
| _version_ | 1848866552916475904 |
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| author | Zolkiply, Izzatul Nadiah Wong, Kah Keng Mohammad Sallehudin, Hakimah Bidin, Mohammad Zulkarnain Che Hamzah, Fahrudin Bahari, Norafida Wan Ghazali, Wan Syamimee |
| author_facet | Zolkiply, Izzatul Nadiah Wong, Kah Keng Mohammad Sallehudin, Hakimah Bidin, Mohammad Zulkarnain Che Hamzah, Fahrudin Bahari, Norafida Wan Ghazali, Wan Syamimee |
| author_sort | Zolkiply, Izzatul Nadiah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Knee osteoarthritis (OA) is a common condition with a prevalence of 365 million individuals globally, and it is an independent risk factor for falls and fractures, notably asymptomatic morphometric vertebral fractures (AMVF). The high prevalence of knee OA, the severity of AMVF, and their combined impacts on quality of life underscore the need for early detection, appropriate treatment and management. To address this, our cross-sectional study aims to identify potential predictive factors associated with AMVF in knee OA patients. Our cohort consisted of 76 patients diagnosed with knee OA, predominantly female (84.2%), of Malay ethnicity (84.2%), and obese (55.3%). In univariable analysis, significant association was found between occupation (moderate or heavy work) and AMVF (p<0.001). Diabetes mellitus comorbidity (p = 0.016) and fat mass percentage (p = 0.027) also demonstrated a significant association with AMVF in knee OA patients. Multivariable logistic regression analysis revealed that an increase in fat mass percentage resulted in decreased AMVF incidence (HR: 0.83, 95% CI: 0.70–0.97; p = 0.018), while occupation (moderate or heavy work) remained a highly significant predictor (HR: 57.76, 95% CI: 4.23–788.57; p = 0.002). These findings support the potential importance of considering occupational activities and body fat composition in managing AMVF among knee OA patients, but further research is required to establish causal relationships. |
| first_indexed | 2025-11-15T14:22:25Z |
| format | Article |
| id | upm-114641 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:22:25Z |
| publishDate | 2024 |
| publisher | Public Library of Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1146412025-01-22T02:14:15Z http://psasir.upm.edu.my/id/eprint/114641/ Work intensity and fat mass percentage are associated with asymptomatic morphometric vertebral fractures in knee osteoarthritis patients: a cross-sectional study Zolkiply, Izzatul Nadiah Wong, Kah Keng Mohammad Sallehudin, Hakimah Bidin, Mohammad Zulkarnain Che Hamzah, Fahrudin Bahari, Norafida Wan Ghazali, Wan Syamimee Knee osteoarthritis (OA) is a common condition with a prevalence of 365 million individuals globally, and it is an independent risk factor for falls and fractures, notably asymptomatic morphometric vertebral fractures (AMVF). The high prevalence of knee OA, the severity of AMVF, and their combined impacts on quality of life underscore the need for early detection, appropriate treatment and management. To address this, our cross-sectional study aims to identify potential predictive factors associated with AMVF in knee OA patients. Our cohort consisted of 76 patients diagnosed with knee OA, predominantly female (84.2%), of Malay ethnicity (84.2%), and obese (55.3%). In univariable analysis, significant association was found between occupation (moderate or heavy work) and AMVF (p<0.001). Diabetes mellitus comorbidity (p = 0.016) and fat mass percentage (p = 0.027) also demonstrated a significant association with AMVF in knee OA patients. Multivariable logistic regression analysis revealed that an increase in fat mass percentage resulted in decreased AMVF incidence (HR: 0.83, 95% CI: 0.70–0.97; p = 0.018), while occupation (moderate or heavy work) remained a highly significant predictor (HR: 57.76, 95% CI: 4.23–788.57; p = 0.002). These findings support the potential importance of considering occupational activities and body fat composition in managing AMVF among knee OA patients, but further research is required to establish causal relationships. Public Library of Science 2024-09-16 Article PeerReviewed text en cc_by_4 http://psasir.upm.edu.my/id/eprint/114641/1/114641.pdf Zolkiply, Izzatul Nadiah and Wong, Kah Keng and Mohammad Sallehudin, Hakimah and Bidin, Mohammad Zulkarnain and Che Hamzah, Fahrudin and Bahari, Norafida and Wan Ghazali, Wan Syamimee (2024) Work intensity and fat mass percentage are associated with asymptomatic morphometric vertebral fractures in knee osteoarthritis patients: a cross-sectional study. PLoS ONE, 19. art. no. e0308746. pp. 1-12. ISSN 1932-6203; eISSN: 1932-6203 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0308746 10.1371/journal.pone.0308746 |
| spellingShingle | Zolkiply, Izzatul Nadiah Wong, Kah Keng Mohammad Sallehudin, Hakimah Bidin, Mohammad Zulkarnain Che Hamzah, Fahrudin Bahari, Norafida Wan Ghazali, Wan Syamimee Work intensity and fat mass percentage are associated with asymptomatic morphometric vertebral fractures in knee osteoarthritis patients: a cross-sectional study |
| title | Work intensity and fat mass percentage are associated with asymptomatic morphometric vertebral fractures in knee osteoarthritis patients: a cross-sectional study |
| title_full | Work intensity and fat mass percentage are associated with asymptomatic morphometric vertebral fractures in knee osteoarthritis patients: a cross-sectional study |
| title_fullStr | Work intensity and fat mass percentage are associated with asymptomatic morphometric vertebral fractures in knee osteoarthritis patients: a cross-sectional study |
| title_full_unstemmed | Work intensity and fat mass percentage are associated with asymptomatic morphometric vertebral fractures in knee osteoarthritis patients: a cross-sectional study |
| title_short | Work intensity and fat mass percentage are associated with asymptomatic morphometric vertebral fractures in knee osteoarthritis patients: a cross-sectional study |
| title_sort | work intensity and fat mass percentage are associated with asymptomatic morphometric vertebral fractures in knee osteoarthritis patients: a cross-sectional study |
| url | http://psasir.upm.edu.my/id/eprint/114641/ http://psasir.upm.edu.my/id/eprint/114641/ http://psasir.upm.edu.my/id/eprint/114641/ http://psasir.upm.edu.my/id/eprint/114641/1/114641.pdf |