Sporotrichosis: an update on epidemiology and in vitro antifungal susceptibilities of Sporothrix schenckii isolated from humans and cats in Klang Valley, Malaysia
The epidemiological pattern of human sporotrichosis infections in Klang Valley, Malaysia and antifungal susceptibility of the causative fungal pathogen, Sporothrix schenckii was determined. A total of 67 culture positive sporotrichosis cases were recorded from 2015-2018 at three Klang Valley hospita...
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| Format: | Article |
| Language: | English |
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Universiti Putra Malaysia Press
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/114474/ http://psasir.upm.edu.my/id/eprint/114474/1/114474.pdf |
| _version_ | 1848866504394670080 |
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| author | Selvarajah, Gayathri Thevi Santhanam, Jacinta Mah, Elizebeth James, Jasper Elvin Abdul Razak, Mohd Fuat Selvakumar, Raja Rajeswari Al-Shaibani, Muhanna M. |
| author_facet | Selvarajah, Gayathri Thevi Santhanam, Jacinta Mah, Elizebeth James, Jasper Elvin Abdul Razak, Mohd Fuat Selvakumar, Raja Rajeswari Al-Shaibani, Muhanna M. |
| author_sort | Selvarajah, Gayathri Thevi |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The epidemiological pattern of human sporotrichosis infections in Klang Valley, Malaysia and antifungal susceptibility of the causative fungal pathogen, Sporothrix schenckii was determined. A total of 67 culture positive sporotrichosis cases were recorded from 2015-2018 at three Klang Valley hospitals, with a majority in the 19-30 years age group. Association with felines represent the highest (47.76%) risk factor for sporotrichosis. The clinical presentation was predominantly lymphocutaneous infection (59.67%). S. schenckii isolates from humans and cats were tested for antifungal susceptibility using the standardized broth microdilution method. All 25 S. schenckii isolates tested were susceptible to itraconazole (MIC 0.5-2 μg/mL), while MIC was lower for ravuconazole (0.125-1 μg/mL). Awareness and emphasis on feline associated sporotrichosis are needed in Malaysia. While itraconazole is the recommended treatment, ravuconazole may be an additional, potentially effective treatment against S. schenckii. |
| first_indexed | 2025-11-15T14:21:39Z |
| format | Article |
| id | upm-114474 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:21:39Z |
| publishDate | 2024 |
| publisher | Universiti Putra Malaysia Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1144742025-01-16T01:42:02Z http://psasir.upm.edu.my/id/eprint/114474/ Sporotrichosis: an update on epidemiology and in vitro antifungal susceptibilities of Sporothrix schenckii isolated from humans and cats in Klang Valley, Malaysia Selvarajah, Gayathri Thevi Santhanam, Jacinta Mah, Elizebeth James, Jasper Elvin Abdul Razak, Mohd Fuat Selvakumar, Raja Rajeswari Al-Shaibani, Muhanna M. The epidemiological pattern of human sporotrichosis infections in Klang Valley, Malaysia and antifungal susceptibility of the causative fungal pathogen, Sporothrix schenckii was determined. A total of 67 culture positive sporotrichosis cases were recorded from 2015-2018 at three Klang Valley hospitals, with a majority in the 19-30 years age group. Association with felines represent the highest (47.76%) risk factor for sporotrichosis. The clinical presentation was predominantly lymphocutaneous infection (59.67%). S. schenckii isolates from humans and cats were tested for antifungal susceptibility using the standardized broth microdilution method. All 25 S. schenckii isolates tested were susceptible to itraconazole (MIC 0.5-2 μg/mL), while MIC was lower for ravuconazole (0.125-1 μg/mL). Awareness and emphasis on feline associated sporotrichosis are needed in Malaysia. While itraconazole is the recommended treatment, ravuconazole may be an additional, potentially effective treatment against S. schenckii. Universiti Putra Malaysia Press 2024 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/114474/1/114474.pdf Selvarajah, Gayathri Thevi and Santhanam, Jacinta and Mah, Elizebeth and James, Jasper Elvin and Abdul Razak, Mohd Fuat and Selvakumar, Raja Rajeswari and Al-Shaibani, Muhanna M. (2024) Sporotrichosis: an update on epidemiology and in vitro antifungal susceptibilities of Sporothrix schenckii isolated from humans and cats in Klang Valley, Malaysia. Malaysian Journal of Medicine and Health Sciences, 20 (4). pp. 375-384. ISSN 1675-8544; eISSN: 2636-9346 https://medic.upm.edu.my/upload/dokumen/2024073110363944_0361.pdf 10.47836/mjmhs.20.4.45 |
| spellingShingle | Selvarajah, Gayathri Thevi Santhanam, Jacinta Mah, Elizebeth James, Jasper Elvin Abdul Razak, Mohd Fuat Selvakumar, Raja Rajeswari Al-Shaibani, Muhanna M. Sporotrichosis: an update on epidemiology and in vitro antifungal susceptibilities of Sporothrix schenckii isolated from humans and cats in Klang Valley, Malaysia |
| title | Sporotrichosis: an update on epidemiology and in vitro antifungal susceptibilities of Sporothrix schenckii isolated from humans and cats in Klang Valley, Malaysia |
| title_full | Sporotrichosis: an update on epidemiology and in vitro antifungal susceptibilities of Sporothrix schenckii isolated from humans and cats in Klang Valley, Malaysia |
| title_fullStr | Sporotrichosis: an update on epidemiology and in vitro antifungal susceptibilities of Sporothrix schenckii isolated from humans and cats in Klang Valley, Malaysia |
| title_full_unstemmed | Sporotrichosis: an update on epidemiology and in vitro antifungal susceptibilities of Sporothrix schenckii isolated from humans and cats in Klang Valley, Malaysia |
| title_short | Sporotrichosis: an update on epidemiology and in vitro antifungal susceptibilities of Sporothrix schenckii isolated from humans and cats in Klang Valley, Malaysia |
| title_sort | sporotrichosis: an update on epidemiology and in vitro antifungal susceptibilities of sporothrix schenckii isolated from humans and cats in klang valley, malaysia |
| url | http://psasir.upm.edu.my/id/eprint/114474/ http://psasir.upm.edu.my/id/eprint/114474/ http://psasir.upm.edu.my/id/eprint/114474/ http://psasir.upm.edu.my/id/eprint/114474/1/114474.pdf |