Using biothesiometer, Neuropathy Symptom Score, and Neuropathy Disability Score for the early detection of peripheral neuropathy: a cross-sectional study
Patients with peripheral neuropathy could have damaged peripheral nerves, which leads to sensory and motor dysfunction. Diabetes, infections, and trauma are the major causes of peripheral neuropathy. Vibratory perception threshold (VPT) tools are commonly used to detect peripheral neuropathy. This s...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Hamad Bin Khalifa University Press
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/114284/ http://psasir.upm.edu.my/id/eprint/114284/1/114284.pdf |
| _version_ | 1848866448137519104 |
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| author | Mooi, Ching Siew Lee, Kai Wei Yusof Khan, Abdul Hanif Khan Devaraj, Navin Kumar Cheong, Ai Theng Hoo, Fan Kee Sulaiman, Wan Aliaa Wan Loh, Wei Chao Jian, Leong Yong Hui, Teh Xian Ramachandran, Vasudevan |
| author_facet | Mooi, Ching Siew Lee, Kai Wei Yusof Khan, Abdul Hanif Khan Devaraj, Navin Kumar Cheong, Ai Theng Hoo, Fan Kee Sulaiman, Wan Aliaa Wan Loh, Wei Chao Jian, Leong Yong Hui, Teh Xian Ramachandran, Vasudevan |
| author_sort | Mooi, Ching Siew |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Patients with peripheral neuropathy could have damaged peripheral nerves, which leads to sensory and motor dysfunction. Diabetes, infections, and trauma are the major causes of peripheral neuropathy. Vibratory perception threshold (VPT) tools are commonly used to detect peripheral neuropathy. This study aims to determine the assessment of peripheral neuropathy through the different diagnostic tools in the community in Malaysia. A total number of 1283 participants were recruited from the seven retail pharmacies located in Selangor, Malaysia. The peripheral neuropathy test was conducted based on VPT tools on both feet using the digital biothesiometer. Following that, Neurological Symptom Score (NSS) and Neurological Disability Score (NDS) were taken from the participants to assess the neurological symptoms. Participants had an average age of 40.6 ± 12.9 years and were mostly of Chinese ethnicity (54.1%). The findings show that increasing age was associated with more severe peripheral neuropathy across the various assessment tools, but gender differences were found with the biothesiometer test and ethnicity has severity in the biothesiometer and disability scores. The sensitivity and specificity of the biothesiometer test were 0.63 and 0.84, respectively. The combined tool NSS and NDS had high specificity and a high positive predictive value, suggesting that it could be a reliable indicator of peripheral neuropathy when both scores are elevated. The findings show that the biothesiometer test, NSS, and NDS are considered screening VPT tools for diagnosing peripheral neuropathy. However, further evaluation and diagnostic testing are necessary in cases of a positive test result. |
| first_indexed | 2025-11-15T14:20:45Z |
| format | Article |
| id | upm-114284 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:20:45Z |
| publishDate | 2024 |
| publisher | Hamad Bin Khalifa University Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1142842025-01-13T07:11:03Z http://psasir.upm.edu.my/id/eprint/114284/ Using biothesiometer, Neuropathy Symptom Score, and Neuropathy Disability Score for the early detection of peripheral neuropathy: a cross-sectional study Mooi, Ching Siew Lee, Kai Wei Yusof Khan, Abdul Hanif Khan Devaraj, Navin Kumar Cheong, Ai Theng Hoo, Fan Kee Sulaiman, Wan Aliaa Wan Loh, Wei Chao Jian, Leong Yong Hui, Teh Xian Ramachandran, Vasudevan Patients with peripheral neuropathy could have damaged peripheral nerves, which leads to sensory and motor dysfunction. Diabetes, infections, and trauma are the major causes of peripheral neuropathy. Vibratory perception threshold (VPT) tools are commonly used to detect peripheral neuropathy. This study aims to determine the assessment of peripheral neuropathy through the different diagnostic tools in the community in Malaysia. A total number of 1283 participants were recruited from the seven retail pharmacies located in Selangor, Malaysia. The peripheral neuropathy test was conducted based on VPT tools on both feet using the digital biothesiometer. Following that, Neurological Symptom Score (NSS) and Neurological Disability Score (NDS) were taken from the participants to assess the neurological symptoms. Participants had an average age of 40.6 ± 12.9 years and were mostly of Chinese ethnicity (54.1%). The findings show that increasing age was associated with more severe peripheral neuropathy across the various assessment tools, but gender differences were found with the biothesiometer test and ethnicity has severity in the biothesiometer and disability scores. The sensitivity and specificity of the biothesiometer test were 0.63 and 0.84, respectively. The combined tool NSS and NDS had high specificity and a high positive predictive value, suggesting that it could be a reliable indicator of peripheral neuropathy when both scores are elevated. The findings show that the biothesiometer test, NSS, and NDS are considered screening VPT tools for diagnosing peripheral neuropathy. However, further evaluation and diagnostic testing are necessary in cases of a positive test result. Hamad Bin Khalifa University Press 2024-08-06 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/114284/1/114284.pdf Mooi, Ching Siew and Lee, Kai Wei and Yusof Khan, Abdul Hanif Khan and Devaraj, Navin Kumar and Cheong, Ai Theng and Hoo, Fan Kee and Sulaiman, Wan Aliaa Wan and Loh, Wei Chao and Jian, Leong Yong and Hui, Teh Xian and Ramachandran, Vasudevan (2024) Using biothesiometer, Neuropathy Symptom Score, and Neuropathy Disability Score for the early detection of peripheral neuropathy: a cross-sectional study. Qatar Medical Journal, 2024 (3). art. no. 24. ISSN 0253-8253; eISSN: 2227-0426 https://www.qscience.com/content/journals/10.5339/qmj.2024.24 10.5339/qmj.2024.24 |
| spellingShingle | Mooi, Ching Siew Lee, Kai Wei Yusof Khan, Abdul Hanif Khan Devaraj, Navin Kumar Cheong, Ai Theng Hoo, Fan Kee Sulaiman, Wan Aliaa Wan Loh, Wei Chao Jian, Leong Yong Hui, Teh Xian Ramachandran, Vasudevan Using biothesiometer, Neuropathy Symptom Score, and Neuropathy Disability Score for the early detection of peripheral neuropathy: a cross-sectional study |
| title | Using biothesiometer, Neuropathy Symptom Score, and Neuropathy Disability Score for the early detection of peripheral neuropathy: a cross-sectional study |
| title_full | Using biothesiometer, Neuropathy Symptom Score, and Neuropathy Disability Score for the early detection of peripheral neuropathy: a cross-sectional study |
| title_fullStr | Using biothesiometer, Neuropathy Symptom Score, and Neuropathy Disability Score for the early detection of peripheral neuropathy: a cross-sectional study |
| title_full_unstemmed | Using biothesiometer, Neuropathy Symptom Score, and Neuropathy Disability Score for the early detection of peripheral neuropathy: a cross-sectional study |
| title_short | Using biothesiometer, Neuropathy Symptom Score, and Neuropathy Disability Score for the early detection of peripheral neuropathy: a cross-sectional study |
| title_sort | using biothesiometer, neuropathy symptom score, and neuropathy disability score for the early detection of peripheral neuropathy: a cross-sectional study |
| url | http://psasir.upm.edu.my/id/eprint/114284/ http://psasir.upm.edu.my/id/eprint/114284/ http://psasir.upm.edu.my/id/eprint/114284/ http://psasir.upm.edu.my/id/eprint/114284/1/114284.pdf |