Detection of 17-α-ethinylestradiol with bio-functionalized tapered optical fiber sensor
This paper presents the utilization of tapered optical fiber (TOF) biosensor for the detection of 17-α-ethinylestradiol (EE2), an estrogen hormone. TOF with a waist diameter of 12 μm was fabricated from single mode fiber using heat and pull method. The tapered area was used as the sensing interface...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/113593/ http://psasir.upm.edu.my/id/eprint/113593/1/113593.pdf |
| _version_ | 1848866269035495424 |
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| author | Hamid, Rosyati Mustapha Kamil, Yasmin Aris, Ahmad Zaharin Abu Bakar, Muhammad Hafiz Suhailin, Fariza Hanim Alresheedi, Mohammed Thamer Ng, Eng Khoon Mahdi, Mohd Adzir |
| author_facet | Hamid, Rosyati Mustapha Kamil, Yasmin Aris, Ahmad Zaharin Abu Bakar, Muhammad Hafiz Suhailin, Fariza Hanim Alresheedi, Mohammed Thamer Ng, Eng Khoon Mahdi, Mohd Adzir |
| author_sort | Hamid, Rosyati |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | This paper presents the utilization of tapered optical fiber (TOF) biosensor for the detection of 17-α-ethinylestradiol (EE2), an estrogen hormone. TOF with a waist diameter of 12 μm was fabricated from single mode fiber using heat and pull method. The tapered area was used as the sensing interface between the evanescent waves propagating around the fiber due to its unique geometry and the attached molecules on the tapered surface. EE2 antibodies were used as biorecognition molecules towards the targeted analyte, EE2. When tested with different concentrations of EE2 within the range of 0.1 ng/L – 1 mg/L, the developed sensor attained a detection limit of 1 ng/L with a sensitivity value of 1.088 nm/ngL-1 within the operation range of 1 – 10 ng/L. The specificity of the sensor was validated by testing the developed sensor with estrone (E1) and no significant wavelength shift was observed. These findings highlight the potential of our approach for sensitive and selective detection of EE2. |
| first_indexed | 2025-11-15T14:17:55Z |
| format | Article |
| id | upm-113593 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:17:55Z |
| publishDate | 2024 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1135932024-11-14T03:56:02Z http://psasir.upm.edu.my/id/eprint/113593/ Detection of 17-α-ethinylestradiol with bio-functionalized tapered optical fiber sensor Hamid, Rosyati Mustapha Kamil, Yasmin Aris, Ahmad Zaharin Abu Bakar, Muhammad Hafiz Suhailin, Fariza Hanim Alresheedi, Mohammed Thamer Ng, Eng Khoon Mahdi, Mohd Adzir This paper presents the utilization of tapered optical fiber (TOF) biosensor for the detection of 17-α-ethinylestradiol (EE2), an estrogen hormone. TOF with a waist diameter of 12 μm was fabricated from single mode fiber using heat and pull method. The tapered area was used as the sensing interface between the evanescent waves propagating around the fiber due to its unique geometry and the attached molecules on the tapered surface. EE2 antibodies were used as biorecognition molecules towards the targeted analyte, EE2. When tested with different concentrations of EE2 within the range of 0.1 ng/L – 1 mg/L, the developed sensor attained a detection limit of 1 ng/L with a sensitivity value of 1.088 nm/ngL-1 within the operation range of 1 – 10 ng/L. The specificity of the sensor was validated by testing the developed sensor with estrone (E1) and no significant wavelength shift was observed. These findings highlight the potential of our approach for sensitive and selective detection of EE2. Elsevier 2024 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/113593/1/113593.pdf Hamid, Rosyati and Mustapha Kamil, Yasmin and Aris, Ahmad Zaharin and Abu Bakar, Muhammad Hafiz and Suhailin, Fariza Hanim and Alresheedi, Mohammed Thamer and Ng, Eng Khoon and Mahdi, Mohd Adzir (2024) Detection of 17-α-ethinylestradiol with bio-functionalized tapered optical fiber sensor. Measurement: Journal of the International Measurement Confederation, 238. art. no. 115305. pp. 1-11. ISSN 0263-2241; eISSN: 0263-2241 https://www.sciencedirect.com/science/article/pii/S0263224124011904?via%3Dihub 10.1016/j.measurement.2024.115305 |
| spellingShingle | Hamid, Rosyati Mustapha Kamil, Yasmin Aris, Ahmad Zaharin Abu Bakar, Muhammad Hafiz Suhailin, Fariza Hanim Alresheedi, Mohammed Thamer Ng, Eng Khoon Mahdi, Mohd Adzir Detection of 17-α-ethinylestradiol with bio-functionalized tapered optical fiber sensor |
| title | Detection of 17-α-ethinylestradiol with bio-functionalized tapered optical fiber sensor |
| title_full | Detection of 17-α-ethinylestradiol with bio-functionalized tapered optical fiber sensor |
| title_fullStr | Detection of 17-α-ethinylestradiol with bio-functionalized tapered optical fiber sensor |
| title_full_unstemmed | Detection of 17-α-ethinylestradiol with bio-functionalized tapered optical fiber sensor |
| title_short | Detection of 17-α-ethinylestradiol with bio-functionalized tapered optical fiber sensor |
| title_sort | detection of 17-α-ethinylestradiol with bio-functionalized tapered optical fiber sensor |
| url | http://psasir.upm.edu.my/id/eprint/113593/ http://psasir.upm.edu.my/id/eprint/113593/ http://psasir.upm.edu.my/id/eprint/113593/ http://psasir.upm.edu.my/id/eprint/113593/1/113593.pdf |