Antioxidant and anti-adipogenic activities of Momordica cochinchinensis (Lour). Spreng fruit extracts
Introduction: Momordica cochinchinensis (Lour) Spreng, known as gac fruit, is rich in bioactive compounds like carotenoids (β-carotene, lycopene, and lutein). This study assessed the antioxidant, cytotoxic, and anti-adipogenic properties of gac fruit extracts (GFE) from different fractions (peel, pu...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universiti Putra Malaysia Press
2024
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/113542/ http://psasir.upm.edu.my/id/eprint/113542/1/113542.pdf |
| _version_ | 1848866255507816448 |
|---|---|
| author | Abdul Rahman, Mohd Nazri Ismail, Amin Azlan, Azrina Abdul Aziz, Ahmad Fazli Muhammad, Nor Hayati |
| author_facet | Abdul Rahman, Mohd Nazri Ismail, Amin Azlan, Azrina Abdul Aziz, Ahmad Fazli Muhammad, Nor Hayati |
| author_sort | Abdul Rahman, Mohd Nazri |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Introduction: Momordica cochinchinensis (Lour) Spreng, known as gac fruit, is rich in bioactive compounds like carotenoids (β-carotene, lycopene, and lutein). This study assessed the antioxidant, cytotoxic, and anti-adipogenic properties of gac fruit extracts (GFE) from different fractions (peel, pulp, aril), using 3T3-L1 adipocytes. Method: Gac extracts’ DPPH radical scavenging was tested with 1000µg/mL dilutions. 3T3-L1 pre-adipocyte viability was measured via MTT assay. Differentiated adipocytes were treated (75, 150, 300 µg/mL) with GFE for 7 days. Inhibitory effects on adipogenesis and lipid accumulation were studied through Oil Red O staining. Triglyceride content was quantified and compared to controls. Results: IC50 values against DPPH radicals were 660µg/mL (peel), 560µg/ mL (pulp), and 820µg/mL (aril). 3T3-L1 cell viability was unaffected up to 200µg/mL. However, 200µg/mL GFE decreased viability, inhibiting growth. Gac extracts effectively reduced lipid accumulation and hindered cell differentiation dose-dependently. Pulp extract notably reduced intracellular triglycerides, surpassing aril and peel effects. Conclusion: Gac fruit extract fractions (peel, pulp, and aril) efficiently inhibited adipogenesis in 3T3-L1 cells, evidenced by lowered lipid accumulation, triglyceride content, and cell viability. This study highlights gac fruit extracts’ potential therapeutic use against obesity. |
| first_indexed | 2025-11-15T14:17:42Z |
| format | Article |
| id | upm-113542 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:17:42Z |
| publishDate | 2024 |
| publisher | Universiti Putra Malaysia Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1135422024-11-26T03:55:32Z http://psasir.upm.edu.my/id/eprint/113542/ Antioxidant and anti-adipogenic activities of Momordica cochinchinensis (Lour). Spreng fruit extracts Abdul Rahman, Mohd Nazri Ismail, Amin Azlan, Azrina Abdul Aziz, Ahmad Fazli Muhammad, Nor Hayati Introduction: Momordica cochinchinensis (Lour) Spreng, known as gac fruit, is rich in bioactive compounds like carotenoids (β-carotene, lycopene, and lutein). This study assessed the antioxidant, cytotoxic, and anti-adipogenic properties of gac fruit extracts (GFE) from different fractions (peel, pulp, aril), using 3T3-L1 adipocytes. Method: Gac extracts’ DPPH radical scavenging was tested with 1000µg/mL dilutions. 3T3-L1 pre-adipocyte viability was measured via MTT assay. Differentiated adipocytes were treated (75, 150, 300 µg/mL) with GFE for 7 days. Inhibitory effects on adipogenesis and lipid accumulation were studied through Oil Red O staining. Triglyceride content was quantified and compared to controls. Results: IC50 values against DPPH radicals were 660µg/mL (peel), 560µg/ mL (pulp), and 820µg/mL (aril). 3T3-L1 cell viability was unaffected up to 200µg/mL. However, 200µg/mL GFE decreased viability, inhibiting growth. Gac extracts effectively reduced lipid accumulation and hindered cell differentiation dose-dependently. Pulp extract notably reduced intracellular triglycerides, surpassing aril and peel effects. Conclusion: Gac fruit extract fractions (peel, pulp, and aril) efficiently inhibited adipogenesis in 3T3-L1 cells, evidenced by lowered lipid accumulation, triglyceride content, and cell viability. This study highlights gac fruit extracts’ potential therapeutic use against obesity. Universiti Putra Malaysia Press 2024 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/113542/1/113542.pdf Abdul Rahman, Mohd Nazri and Ismail, Amin and Azlan, Azrina and Abdul Aziz, Ahmad Fazli and Muhammad, Nor Hayati (2024) Antioxidant and anti-adipogenic activities of Momordica cochinchinensis (Lour). Spreng fruit extracts. Malaysian Journal of Medicine and Health Sciences, 20 (3). pp. 193-202. ISSN 1675-8544; eISSN: 2636-9346 https://doi.org/10.47836%2Fmjmhs.20.3.26 10.47836/mjmhs.20.3.26 |
| spellingShingle | Abdul Rahman, Mohd Nazri Ismail, Amin Azlan, Azrina Abdul Aziz, Ahmad Fazli Muhammad, Nor Hayati Antioxidant and anti-adipogenic activities of Momordica cochinchinensis (Lour). Spreng fruit extracts |
| title | Antioxidant and anti-adipogenic activities of Momordica cochinchinensis (Lour). Spreng fruit extracts |
| title_full | Antioxidant and anti-adipogenic activities of Momordica cochinchinensis (Lour). Spreng fruit extracts |
| title_fullStr | Antioxidant and anti-adipogenic activities of Momordica cochinchinensis (Lour). Spreng fruit extracts |
| title_full_unstemmed | Antioxidant and anti-adipogenic activities of Momordica cochinchinensis (Lour). Spreng fruit extracts |
| title_short | Antioxidant and anti-adipogenic activities of Momordica cochinchinensis (Lour). Spreng fruit extracts |
| title_sort | antioxidant and anti-adipogenic activities of momordica cochinchinensis (lour). spreng fruit extracts |
| url | http://psasir.upm.edu.my/id/eprint/113542/ http://psasir.upm.edu.my/id/eprint/113542/ http://psasir.upm.edu.my/id/eprint/113542/ http://psasir.upm.edu.my/id/eprint/113542/1/113542.pdf |