Ameliorative effect of α-tocopherol and tocotrienol-rich palm oil extract on menopausal-associated mood disorder in ovariectomised mice
Menopausal-associated mood disorder is characterized by emotional depression, anxiety, and stress, which accompany hypogonadism in women in the menopausal phase. The current treatment for menopausal-associated mood disorder provides only symptomatic relief and is associated with many side effects. S...
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| Format: | Article |
| Language: | English |
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Elsevier
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/113318/ http://psasir.upm.edu.my/id/eprint/113318/3/113318.pdf |
| _version_ | 1848866189847035904 |
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| author | Gengfan, Liang Audrey Siew Foong, Kow Yu Zhao, Lee Rohana, Yusof Chau Ling, Tham Yu-Chung, Ho Ming Tatt, Lee |
| author_facet | Gengfan, Liang Audrey Siew Foong, Kow Yu Zhao, Lee Rohana, Yusof Chau Ling, Tham Yu-Chung, Ho Ming Tatt, Lee |
| author_sort | Gengfan, Liang |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Menopausal-associated mood disorder is characterized by emotional depression, anxiety, and stress, which accompany hypogonadism in women in the menopausal phase. The current treatment for menopausal-associated mood disorder provides only symptomatic relief and is associated with many side effects. Supplementation with vitamin E has been shown to be effective in ameliorating anxiety and depression. However, the effects of vitamin E and its underlying mechanism in ameliorating menopausal-associated mood disorders remain uncertain. This work evaluated the effects of α-tocopherol and tocotrienol-rich palm oil extract on depressive and anxiety-related phenotypes induced by estrogen deficiency through ovariectomy in mice. Our study revealed that ovariectomized mice exhibited alterations in behavior indicative of depressive- and anxiety-like behaviors. The serum corticosterone level, a glucocorticoid hormone associated with stress, was found to be elevated in ovariectomized mice as compared to the sham group. Oral administration of α-tocopherol (50 and 100 mg/kg) and tocotrienol-rich palm oil extract (100 and 200 mg/kg) for 14 days alleviated these behavioral changes, as observed in open field, social interaction, and tail suspension tests. However, treatment with tocotrienol-rich palm oil extract, but not α-tocopherol, modulated the depressive- and anxiety-like responses in ovariectomized mice subjected to chronic restraint stress. Both treatments suppressed the elevated serum corticosterone level. Our findings suggested that α-tocopherol and tocotrienol-rich palm oil extract alleviated menopause-associated mood disorder, at least in part, by modulating the hypothalamic-pituitary-adrenal (HPA) axis. The findings of this study can provide a new foundation for the treatment of menopause-associated depressive- and anxiety-like phenotypes, for the betterment of psychological wellbeing. |
| first_indexed | 2025-11-15T14:16:39Z |
| format | Article |
| id | upm-113318 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:16:39Z |
| publishDate | 2024 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1133182024-11-19T07:35:48Z http://psasir.upm.edu.my/id/eprint/113318/ Ameliorative effect of α-tocopherol and tocotrienol-rich palm oil extract on menopausal-associated mood disorder in ovariectomised mice Gengfan, Liang Audrey Siew Foong, Kow Yu Zhao, Lee Rohana, Yusof Chau Ling, Tham Yu-Chung, Ho Ming Tatt, Lee Menopausal-associated mood disorder is characterized by emotional depression, anxiety, and stress, which accompany hypogonadism in women in the menopausal phase. The current treatment for menopausal-associated mood disorder provides only symptomatic relief and is associated with many side effects. Supplementation with vitamin E has been shown to be effective in ameliorating anxiety and depression. However, the effects of vitamin E and its underlying mechanism in ameliorating menopausal-associated mood disorders remain uncertain. This work evaluated the effects of α-tocopherol and tocotrienol-rich palm oil extract on depressive and anxiety-related phenotypes induced by estrogen deficiency through ovariectomy in mice. Our study revealed that ovariectomized mice exhibited alterations in behavior indicative of depressive- and anxiety-like behaviors. The serum corticosterone level, a glucocorticoid hormone associated with stress, was found to be elevated in ovariectomized mice as compared to the sham group. Oral administration of α-tocopherol (50 and 100 mg/kg) and tocotrienol-rich palm oil extract (100 and 200 mg/kg) for 14 days alleviated these behavioral changes, as observed in open field, social interaction, and tail suspension tests. However, treatment with tocotrienol-rich palm oil extract, but not α-tocopherol, modulated the depressive- and anxiety-like responses in ovariectomized mice subjected to chronic restraint stress. Both treatments suppressed the elevated serum corticosterone level. Our findings suggested that α-tocopherol and tocotrienol-rich palm oil extract alleviated menopause-associated mood disorder, at least in part, by modulating the hypothalamic-pituitary-adrenal (HPA) axis. The findings of this study can provide a new foundation for the treatment of menopause-associated depressive- and anxiety-like phenotypes, for the betterment of psychological wellbeing. Elsevier 2024-11-19 Article PeerReviewed text en cc_by_nc_nd_4 http://psasir.upm.edu.my/id/eprint/113318/3/113318.pdf Gengfan, Liang and Audrey Siew Foong, Kow and Yu Zhao, Lee and Rohana, Yusof and Chau Ling, Tham and Yu-Chung, Ho and Ming Tatt, Lee (2024) Ameliorative effect of α-tocopherol and tocotrienol-rich palm oil extract on menopausal-associated mood disorder in ovariectomised mice. Biochemical and Biophysical Research Communications, 734. art. no. 150443. pp. 1-6. ISSN 0006-291X; eISSN: 1090-2104 https://www.sciencedirect.com/science/article/abs/pii/S0006291X24009793 10.1016/j.bbrc.2024.150443 |
| spellingShingle | Gengfan, Liang Audrey Siew Foong, Kow Yu Zhao, Lee Rohana, Yusof Chau Ling, Tham Yu-Chung, Ho Ming Tatt, Lee Ameliorative effect of α-tocopherol and tocotrienol-rich palm oil extract on menopausal-associated mood disorder in ovariectomised mice |
| title | Ameliorative effect of α-tocopherol and tocotrienol-rich palm oil extract on menopausal-associated mood disorder in ovariectomised mice |
| title_full | Ameliorative effect of α-tocopherol and tocotrienol-rich palm oil extract on menopausal-associated mood disorder in ovariectomised mice |
| title_fullStr | Ameliorative effect of α-tocopherol and tocotrienol-rich palm oil extract on menopausal-associated mood disorder in ovariectomised mice |
| title_full_unstemmed | Ameliorative effect of α-tocopherol and tocotrienol-rich palm oil extract on menopausal-associated mood disorder in ovariectomised mice |
| title_short | Ameliorative effect of α-tocopherol and tocotrienol-rich palm oil extract on menopausal-associated mood disorder in ovariectomised mice |
| title_sort | ameliorative effect of α-tocopherol and tocotrienol-rich palm oil extract on menopausal-associated mood disorder in ovariectomised mice |
| url | http://psasir.upm.edu.my/id/eprint/113318/ http://psasir.upm.edu.my/id/eprint/113318/ http://psasir.upm.edu.my/id/eprint/113318/ http://psasir.upm.edu.my/id/eprint/113318/3/113318.pdf |