The utility of [18]F-fluorocholine positron emission computed tomography and [18]F-fluorodeoxyglucose positron emission tomography–computed tomography in evaluating breast cancer phenotypes: a pilot study
Background: The utility of the [18]F fluorodeoxyglucose positron emission tomography–computed tomography ([18]F FDG PET-CT) marker for breast cancer is well established. Given its limitations in localizing FDG-negative malignant tumors, the expression of [18]F-fluorocholine ([18]-FCH) may potentiall...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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AVES
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/113075/ http://psasir.upm.edu.my/id/eprint/113075/1/113075.pdf |
| _version_ | 1848866119585103872 |
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| author | Zakaria, Mohd Hazeman Shaharudin, Shazreen Ahmad Saad, Fathinul Fikri |
| author_facet | Zakaria, Mohd Hazeman Shaharudin, Shazreen Ahmad Saad, Fathinul Fikri |
| author_sort | Zakaria, Mohd Hazeman |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Background: The utility of the [18]F fluorodeoxyglucose positron emission tomography–computed tomography ([18]F FDG PET-CT) marker for breast cancer is well established. Given its limitations in localizing FDG-negative malignant tumors, the expression of [18]F-fluorocholine ([18]-FCH) may potentially be helpful to improve the overall accuracy in evaluating breast cancer. This study determined the potential of [18]FCH PET CT as a potential marker in assessing breast cancer phenotypes. Methods: We recruited consecutive patients with biopsy-proven breast carcinoma who underwent [18] F-FCH PET-CT following the [18]F-FDG PET-CT imaging. The subjects were dichotomized into human epidermal growth factor receptor 2 (HER2)-negative and HER2-positive genotypes. The maximum standardized uptake value (SUVmax; g/dL) was used to predict the two groups of variables. Global health status (GHS) score based on the EORTC quality of life questionnaire (QLQ) was used to evaluate the outcome of the cohort subjects at 6, 12, and 24 months. Results: There were 21 females with a mean age of 54.48 ± 12.17 years. Eighteen patients had invasive ductal carcinoma (18/21;85.8%) on histology, with 11 (52.4%) were HER2-negative genotype. There was higher sensitivity and specificity of [18]-FCH-PET/CT in breast lesions at 40% and 68.8% compared to [18]FDGPET/CT with 33.3% and 66.7%, respectively. There were significant differences between [18]F-FCH SUVmax (g/dL) of the HER-negative as compared to the HER2-positive group (1.99 g/dL vs. 0.2 g/dL; P < .05). High SUVmax (g/dL) of [18]F-FCH had predicted the HER-negative genotype at the cutoff value of 0.75 (P < .05). High [18]F-FCH showed significantly poor scoring of GHS parameters compared to low FCH at 6 months (mean SUVmax 8.06 vs. 5.40 respectively; P < .05). Conclusion: [18]F-FCH PET-CT is a potential marker in localizing and predicting aggressive breast carcinoma phenotypes. |
| first_indexed | 2025-11-15T14:15:32Z |
| format | Article |
| id | upm-113075 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:15:32Z |
| publishDate | 2024 |
| publisher | AVES |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1130752024-11-15T07:06:35Z http://psasir.upm.edu.my/id/eprint/113075/ The utility of [18]F-fluorocholine positron emission computed tomography and [18]F-fluorodeoxyglucose positron emission tomography–computed tomography in evaluating breast cancer phenotypes: a pilot study Zakaria, Mohd Hazeman Shaharudin, Shazreen Ahmad Saad, Fathinul Fikri Background: The utility of the [18]F fluorodeoxyglucose positron emission tomography–computed tomography ([18]F FDG PET-CT) marker for breast cancer is well established. Given its limitations in localizing FDG-negative malignant tumors, the expression of [18]F-fluorocholine ([18]-FCH) may potentially be helpful to improve the overall accuracy in evaluating breast cancer. This study determined the potential of [18]FCH PET CT as a potential marker in assessing breast cancer phenotypes. Methods: We recruited consecutive patients with biopsy-proven breast carcinoma who underwent [18] F-FCH PET-CT following the [18]F-FDG PET-CT imaging. The subjects were dichotomized into human epidermal growth factor receptor 2 (HER2)-negative and HER2-positive genotypes. The maximum standardized uptake value (SUVmax; g/dL) was used to predict the two groups of variables. Global health status (GHS) score based on the EORTC quality of life questionnaire (QLQ) was used to evaluate the outcome of the cohort subjects at 6, 12, and 24 months. Results: There were 21 females with a mean age of 54.48 ± 12.17 years. Eighteen patients had invasive ductal carcinoma (18/21;85.8%) on histology, with 11 (52.4%) were HER2-negative genotype. There was higher sensitivity and specificity of [18]-FCH-PET/CT in breast lesions at 40% and 68.8% compared to [18]FDGPET/CT with 33.3% and 66.7%, respectively. There were significant differences between [18]F-FCH SUVmax (g/dL) of the HER-negative as compared to the HER2-positive group (1.99 g/dL vs. 0.2 g/dL; P < .05). High SUVmax (g/dL) of [18]F-FCH had predicted the HER-negative genotype at the cutoff value of 0.75 (P < .05). High [18]F-FCH showed significantly poor scoring of GHS parameters compared to low FCH at 6 months (mean SUVmax 8.06 vs. 5.40 respectively; P < .05). Conclusion: [18]F-FCH PET-CT is a potential marker in localizing and predicting aggressive breast carcinoma phenotypes. AVES 2024 Article PeerReviewed text en cc_by_4 http://psasir.upm.edu.my/id/eprint/113075/1/113075.pdf Zakaria, Mohd Hazeman and Shaharudin, Shazreen and Ahmad Saad, Fathinul Fikri (2024) The utility of [18]F-fluorocholine positron emission computed tomography and [18]F-fluorodeoxyglucose positron emission tomography–computed tomography in evaluating breast cancer phenotypes: a pilot study. Eurasian Journal of Medicine, 56 (2). pp. 78-85. ISSN 1308-8734; eISSN: 1308-8742 https://www.eajm.org/en/the-utility-of-18-f-fluorocholine-positron-emission-computed-tomography-and-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-evaluating-breast-cancer-phenotypes-a-pilot-study-133558 10.5152/eurasianjmed.2024.23047 |
| spellingShingle | Zakaria, Mohd Hazeman Shaharudin, Shazreen Ahmad Saad, Fathinul Fikri The utility of [18]F-fluorocholine positron emission computed tomography and [18]F-fluorodeoxyglucose positron emission tomography–computed tomography in evaluating breast cancer phenotypes: a pilot study |
| title | The utility of [18]F-fluorocholine positron emission computed tomography and [18]F-fluorodeoxyglucose positron emission tomography–computed tomography in evaluating breast cancer phenotypes: a pilot study |
| title_full | The utility of [18]F-fluorocholine positron emission computed tomography and [18]F-fluorodeoxyglucose positron emission tomography–computed tomography in evaluating breast cancer phenotypes: a pilot study |
| title_fullStr | The utility of [18]F-fluorocholine positron emission computed tomography and [18]F-fluorodeoxyglucose positron emission tomography–computed tomography in evaluating breast cancer phenotypes: a pilot study |
| title_full_unstemmed | The utility of [18]F-fluorocholine positron emission computed tomography and [18]F-fluorodeoxyglucose positron emission tomography–computed tomography in evaluating breast cancer phenotypes: a pilot study |
| title_short | The utility of [18]F-fluorocholine positron emission computed tomography and [18]F-fluorodeoxyglucose positron emission tomography–computed tomography in evaluating breast cancer phenotypes: a pilot study |
| title_sort | utility of [18]f-fluorocholine positron emission computed tomography and [18]f-fluorodeoxyglucose positron emission tomography–computed tomography in evaluating breast cancer phenotypes: a pilot study |
| url | http://psasir.upm.edu.my/id/eprint/113075/ http://psasir.upm.edu.my/id/eprint/113075/ http://psasir.upm.edu.my/id/eprint/113075/ http://psasir.upm.edu.my/id/eprint/113075/1/113075.pdf |