Seroprevalence of antibodies to hepatitis E virus in the normal blood donor population and two aboriginal communities in Malaysia
The prevalence of antibodies to hepatitis E virus (HEV) has been examined in many countries, but such studies have generally been limited to majority populations such as those represented in healthy blood donors or cross sections of urban populations. Due to its major route of enteric transmission,...
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| Format: | Article |
| Language: | English |
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Wiley
1999
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| Online Access: | http://psasir.upm.edu.my/id/eprint/112995/ http://psasir.upm.edu.my/id/eprint/112995/2/112995.pdf |
| _version_ | 1848866099136823296 |
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| author | Seow, Heng-Fong Bali Mahomed, Nizam Malik Mak, Joon-Wah Riddell, Michaela A. Li, Fan Anderson, David A. |
| author_facet | Seow, Heng-Fong Bali Mahomed, Nizam Malik Mak, Joon-Wah Riddell, Michaela A. Li, Fan Anderson, David A. |
| author_sort | Seow, Heng-Fong |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The prevalence of antibodies to hepatitis E virus (HEV) has been examined in many countries, but such studies have generally been limited to majority populations such as those represented in healthy blood donors or cross sections of urban populations. Due to its major route of enteric transmission, large differences in HEV prevalence might be expected between populations in the same country but with different living conditions. Using an ELISA based on GST-ORF2.1 antigen, the prevalence of IgG-class antibodies to HEV was examined in three distinct populations in Malaysia: the normal (urban) blood donor population and two aboriginal communities located at Betau, Pahang and Parit Tanjung, Perak. IgG anti-HEV was detected in 45 (44%) of 102 samples from Betau and 15 (50%) of 30 samples from Parit Tanjung, compared to only 2 (2%) of 100 normal blood donors. The distribution of sample ELISA reactivities was also consistent with ongoing sporadic infection in the aboriginal communities, while there was no significant relationship between HEV exposure and age, sex, or malaria infection. The high prevalence of antibodies to HEV in the two aboriginal communities indicates that this group of people are at high risk of exposure to HEV compared to the general blood donors, and the results suggest that studies of HEV seroprevalence within countries must take into account the possibility of widely varying infection rates between populations with marked differences in living conditions. |
| first_indexed | 2025-11-15T14:15:13Z |
| format | Article |
| id | upm-112995 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:15:13Z |
| publishDate | 1999 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1129952025-01-27T06:45:36Z http://psasir.upm.edu.my/id/eprint/112995/ Seroprevalence of antibodies to hepatitis E virus in the normal blood donor population and two aboriginal communities in Malaysia Seow, Heng-Fong Bali Mahomed, Nizam Malik Mak, Joon-Wah Riddell, Michaela A. Li, Fan Anderson, David A. The prevalence of antibodies to hepatitis E virus (HEV) has been examined in many countries, but such studies have generally been limited to majority populations such as those represented in healthy blood donors or cross sections of urban populations. Due to its major route of enteric transmission, large differences in HEV prevalence might be expected between populations in the same country but with different living conditions. Using an ELISA based on GST-ORF2.1 antigen, the prevalence of IgG-class antibodies to HEV was examined in three distinct populations in Malaysia: the normal (urban) blood donor population and two aboriginal communities located at Betau, Pahang and Parit Tanjung, Perak. IgG anti-HEV was detected in 45 (44%) of 102 samples from Betau and 15 (50%) of 30 samples from Parit Tanjung, compared to only 2 (2%) of 100 normal blood donors. The distribution of sample ELISA reactivities was also consistent with ongoing sporadic infection in the aboriginal communities, while there was no significant relationship between HEV exposure and age, sex, or malaria infection. The high prevalence of antibodies to HEV in the two aboriginal communities indicates that this group of people are at high risk of exposure to HEV compared to the general blood donors, and the results suggest that studies of HEV seroprevalence within countries must take into account the possibility of widely varying infection rates between populations with marked differences in living conditions. Wiley 1999 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/112995/2/112995.pdf Seow, Heng-Fong and Bali Mahomed, Nizam Malik and Mak, Joon-Wah and Riddell, Michaela A. and Li, Fan and Anderson, David A. (1999) Seroprevalence of antibodies to hepatitis E virus in the normal blood donor population and two aboriginal communities in Malaysia. Journal of Medical Virology, 59 (2). pp. 164-168. ISSN 0146-6615; eISSN: 1096-9071 https://onlinelibrary.wiley.com/doi/10.1002/(SICI)1096-9071(199910)59:2%3C164::AID-JMV7%3E3.0.CO;2-J 10.1002/(sici)1096-9071(199910)59:2<164::aid-jmv7>3.0.co;2-j |
| spellingShingle | Seow, Heng-Fong Bali Mahomed, Nizam Malik Mak, Joon-Wah Riddell, Michaela A. Li, Fan Anderson, David A. Seroprevalence of antibodies to hepatitis E virus in the normal blood donor population and two aboriginal communities in Malaysia |
| title | Seroprevalence of antibodies to hepatitis E virus in the normal blood donor population and two aboriginal communities in Malaysia |
| title_full | Seroprevalence of antibodies to hepatitis E virus in the normal blood donor population and two aboriginal communities in Malaysia |
| title_fullStr | Seroprevalence of antibodies to hepatitis E virus in the normal blood donor population and two aboriginal communities in Malaysia |
| title_full_unstemmed | Seroprevalence of antibodies to hepatitis E virus in the normal blood donor population and two aboriginal communities in Malaysia |
| title_short | Seroprevalence of antibodies to hepatitis E virus in the normal blood donor population and two aboriginal communities in Malaysia |
| title_sort | seroprevalence of antibodies to hepatitis e virus in the normal blood donor population and two aboriginal communities in malaysia |
| url | http://psasir.upm.edu.my/id/eprint/112995/ http://psasir.upm.edu.my/id/eprint/112995/ http://psasir.upm.edu.my/id/eprint/112995/ http://psasir.upm.edu.my/id/eprint/112995/2/112995.pdf |