Marrow fat‐cortical bone relationship in β‐thalassemia: a study using MRI
Background: Growing evidence suggests that marrow adipocytes play an active role in the regulation of bone metabolism and hematopoiesis. However, research on the relationship between bone and fat in the context of hematological diseases, particularly β-thalassemia, remains limited. Purpose: To inves...
| Main Authors: | , , , , , , , |
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| Format: | Article |
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John Wiley and Sons
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/112840/ |
| _version_ | 1848866052353556480 |
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| author | Ismail, Umi Nabilah Azlan, Che Ahmad Khairullah, Shasha Azman, Raja Rizal Omar, Nur Farhayu Md Shah, Mohammad Nazri Jackson, Nicholas Ng, Kwan Hoong |
| author_facet | Ismail, Umi Nabilah Azlan, Che Ahmad Khairullah, Shasha Azman, Raja Rizal Omar, Nur Farhayu Md Shah, Mohammad Nazri Jackson, Nicholas Ng, Kwan Hoong |
| author_sort | Ismail, Umi Nabilah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Background: Growing evidence suggests that marrow adipocytes play an active role in the regulation of bone metabolism and hematopoiesis. However, research on the relationship between bone and fat in the context of hematological diseases, particularly β-thalassemia, remains limited. Purpose: To investigate the relationship between marrow fat and cortical bone thickness in β-thalassemia and to identify key determinants influencing these variables. Study Type: Prospective. Subjects: Thirty-five subjects in four subject groups of increasing disease severity: 6 healthy control (25.0 ± 5.3 years, 2 male), 4 β-thalassemia minor, 13 intermedia, and 12 major (29.1 ± 6.4 years, 15 male). Field Strength/Sequence: 3.0 T, 3D fast low angle shot sequence and T1-weighted turbo spin echo. Assessment: Analyses on proton density fat fraction (PDFF) and R2* values in femur subregions (femoral head, greater trochanter, intertrochanteric, diaphysis, distal) and cortical thickness (CBI) of the subjects' left femur. Clinical data such as age, sex, body mass index (BMI), and disease severity were also included. Statistical Tests: One-way analysis of variance (ANOVA), mixed ANOVA, Pearson correlation and multiple regression. P-values <0.05 were considered significant. Results: Bone marrow PDFF significantly varied between the femur subregions, F(2.89,89.63) = 44.185 and disease severity, F(1,3) = 12.357. A significant interaction between subject groups and femur subregions on bone marrow PDFF was observed, F(8.67,89.63) = 3.723. Notably, a moderate positive correlation was observed between PDFF and CBI (r = 0.33–0.45). Multiple regression models for both PDFF (R2 = 0.476, F(13,151) = 10.547) and CBI (R2 = 0.477, F(13,151) = 10.580) were significant. Significant predictors for PDFF were disease severity (βTMi = 0.36, βTMa = 0.17), CBI (β = 0.24), R2* (β = −0.32), and height (β = −0.29) while for CBI, the significant determinants were sex (β = −0.27), BMI (β = 0.55), disease severity (βTMi = 2.15), and PDFF (β = 0.25). Data Conclusion: This study revealed a positive correlation between bone marrow fat fraction and cortical bone thickness in β-thalassemia with varying disease severity, potentially indicating a complex interplay between bone health and marrow composition. Evidence Level: 2. Technical Efficacy: Stage 3. © 2024 International Society for Magnetic Resonance in Medicine. |
| first_indexed | 2025-11-15T14:14:28Z |
| format | Article |
| id | upm-112840 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T14:14:28Z |
| publishDate | 2024 |
| publisher | John Wiley and Sons |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1128402024-11-06T04:13:26Z http://psasir.upm.edu.my/id/eprint/112840/ Marrow fat‐cortical bone relationship in β‐thalassemia: a study using MRI Ismail, Umi Nabilah Azlan, Che Ahmad Khairullah, Shasha Azman, Raja Rizal Omar, Nur Farhayu Md Shah, Mohammad Nazri Jackson, Nicholas Ng, Kwan Hoong Background: Growing evidence suggests that marrow adipocytes play an active role in the regulation of bone metabolism and hematopoiesis. However, research on the relationship between bone and fat in the context of hematological diseases, particularly β-thalassemia, remains limited. Purpose: To investigate the relationship between marrow fat and cortical bone thickness in β-thalassemia and to identify key determinants influencing these variables. Study Type: Prospective. Subjects: Thirty-five subjects in four subject groups of increasing disease severity: 6 healthy control (25.0 ± 5.3 years, 2 male), 4 β-thalassemia minor, 13 intermedia, and 12 major (29.1 ± 6.4 years, 15 male). Field Strength/Sequence: 3.0 T, 3D fast low angle shot sequence and T1-weighted turbo spin echo. Assessment: Analyses on proton density fat fraction (PDFF) and R2* values in femur subregions (femoral head, greater trochanter, intertrochanteric, diaphysis, distal) and cortical thickness (CBI) of the subjects' left femur. Clinical data such as age, sex, body mass index (BMI), and disease severity were also included. Statistical Tests: One-way analysis of variance (ANOVA), mixed ANOVA, Pearson correlation and multiple regression. P-values <0.05 were considered significant. Results: Bone marrow PDFF significantly varied between the femur subregions, F(2.89,89.63) = 44.185 and disease severity, F(1,3) = 12.357. A significant interaction between subject groups and femur subregions on bone marrow PDFF was observed, F(8.67,89.63) = 3.723. Notably, a moderate positive correlation was observed between PDFF and CBI (r = 0.33–0.45). Multiple regression models for both PDFF (R2 = 0.476, F(13,151) = 10.547) and CBI (R2 = 0.477, F(13,151) = 10.580) were significant. Significant predictors for PDFF were disease severity (βTMi = 0.36, βTMa = 0.17), CBI (β = 0.24), R2* (β = −0.32), and height (β = −0.29) while for CBI, the significant determinants were sex (β = −0.27), BMI (β = 0.55), disease severity (βTMi = 2.15), and PDFF (β = 0.25). Data Conclusion: This study revealed a positive correlation between bone marrow fat fraction and cortical bone thickness in β-thalassemia with varying disease severity, potentially indicating a complex interplay between bone health and marrow composition. Evidence Level: 2. Technical Efficacy: Stage 3. © 2024 International Society for Magnetic Resonance in Medicine. John Wiley and Sons 2024 Article PeerReviewed Ismail, Umi Nabilah and Azlan, Che Ahmad and Khairullah, Shasha and Azman, Raja Rizal and Omar, Nur Farhayu and Md Shah, Mohammad Nazri and Jackson, Nicholas and Ng, Kwan Hoong (2024) Marrow fat‐cortical bone relationship in β‐thalassemia: a study using MRI. Journal of Magnetic Resonance Imaging. ISSN 1053-1807; eISSN: 1522-2586 https://onlinelibrary.wiley.com/doi/10.1002/jmri.29366 10.1002/jmri.29366 |
| spellingShingle | Ismail, Umi Nabilah Azlan, Che Ahmad Khairullah, Shasha Azman, Raja Rizal Omar, Nur Farhayu Md Shah, Mohammad Nazri Jackson, Nicholas Ng, Kwan Hoong Marrow fat‐cortical bone relationship in β‐thalassemia: a study using MRI |
| title | Marrow fat‐cortical bone relationship in β‐thalassemia: a study using MRI |
| title_full | Marrow fat‐cortical bone relationship in β‐thalassemia: a study using MRI |
| title_fullStr | Marrow fat‐cortical bone relationship in β‐thalassemia: a study using MRI |
| title_full_unstemmed | Marrow fat‐cortical bone relationship in β‐thalassemia: a study using MRI |
| title_short | Marrow fat‐cortical bone relationship in β‐thalassemia: a study using MRI |
| title_sort | marrow fat‐cortical bone relationship in β‐thalassemia: a study using mri |
| url | http://psasir.upm.edu.my/id/eprint/112840/ http://psasir.upm.edu.my/id/eprint/112840/ http://psasir.upm.edu.my/id/eprint/112840/ |