Synthesis and characterization of cellulose nanocrystals/Gd2O3 nanocomposite as a dual-mode contrast agent for MRI via gamma-ray irradiation
This study developed a biocompatible nanocomposite using cellulose nanocrystals (CNCs), polyethylene glycol (PEG), and sodium hydroxide (NaOH), combined with gadolinium oxide nanoparticles (Gd2O3-NPs) through gamma radiation to decrease the size of nanoparticles and increase their uniformity. This r...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Published: |
Elsevier
2024
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/112790/ |
| _version_ | 1848866038398058496 |
|---|---|
| author | Whba, Fathyah Mohamed, Faizal Whba, Rawdah Idris, Mohd Idzat Mohd Noor, Noramaliza Mahmood, Mohamad Khiari |
| author_facet | Whba, Fathyah Mohamed, Faizal Whba, Rawdah Idris, Mohd Idzat Mohd Noor, Noramaliza Mahmood, Mohamad Khiari |
| author_sort | Whba, Fathyah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | This study developed a biocompatible nanocomposite using cellulose nanocrystals (CNCs), polyethylene glycol (PEG), and sodium hydroxide (NaOH), combined with gadolinium oxide nanoparticles (Gd2O3-NPs) through gamma radiation to decrease the size of nanoparticles and increase their uniformity. This research found that the (CNCs-PEG/NaOH)/Gd2O3 nanocomposite exhibits notable characteristics, including high saturation magnetization (1.44 emu/g), remarkable colloidal stability with a highly negative surface charge of −31.4 mV, and a small hydrodynamic size of 5.5 ± 0.7 nm. Furthermore, the MTT assay conducted on HeLa cell lines revealed the excellent biocompatibility of the (CNCs-PEG/NaOH)/Gd2O3 nanocomposite. No cytotoxic effects were observed, and the nanocomposite exhibited adequate cellular uptake. Moreover, the (CNCs-PEG/NaOH)/Gd2O3 nanocomposite displayed a remarkable enhancement effect on both T1 and T2-weighted images, with high r1 and r2 relaxivity values of 21.694 mM−1 s−1 and 43.799 mM−1 s−1, respectively, resulting in a relaxivity ratio (r2/r1) of 2.02 when compared to clinical and commercial agents. This biocompatible nanocomposite holds promise as a dual contrast agent in MRI and various other biomedical applications. It is envisaged that gamma irradiation is a good method to produce nanoparticles within the nanoscale range. © 2024 Elsevier Ltd |
| first_indexed | 2025-11-15T14:14:15Z |
| format | Article |
| id | upm-112790 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T14:14:15Z |
| publishDate | 2024 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1127902024-11-11T08:32:32Z http://psasir.upm.edu.my/id/eprint/112790/ Synthesis and characterization of cellulose nanocrystals/Gd2O3 nanocomposite as a dual-mode contrast agent for MRI via gamma-ray irradiation Whba, Fathyah Mohamed, Faizal Whba, Rawdah Idris, Mohd Idzat Mohd Noor, Noramaliza Mahmood, Mohamad Khiari This study developed a biocompatible nanocomposite using cellulose nanocrystals (CNCs), polyethylene glycol (PEG), and sodium hydroxide (NaOH), combined with gadolinium oxide nanoparticles (Gd2O3-NPs) through gamma radiation to decrease the size of nanoparticles and increase their uniformity. This research found that the (CNCs-PEG/NaOH)/Gd2O3 nanocomposite exhibits notable characteristics, including high saturation magnetization (1.44 emu/g), remarkable colloidal stability with a highly negative surface charge of −31.4 mV, and a small hydrodynamic size of 5.5 ± 0.7 nm. Furthermore, the MTT assay conducted on HeLa cell lines revealed the excellent biocompatibility of the (CNCs-PEG/NaOH)/Gd2O3 nanocomposite. No cytotoxic effects were observed, and the nanocomposite exhibited adequate cellular uptake. Moreover, the (CNCs-PEG/NaOH)/Gd2O3 nanocomposite displayed a remarkable enhancement effect on both T1 and T2-weighted images, with high r1 and r2 relaxivity values of 21.694 mM−1 s−1 and 43.799 mM−1 s−1, respectively, resulting in a relaxivity ratio (r2/r1) of 2.02 when compared to clinical and commercial agents. This biocompatible nanocomposite holds promise as a dual contrast agent in MRI and various other biomedical applications. It is envisaged that gamma irradiation is a good method to produce nanoparticles within the nanoscale range. © 2024 Elsevier Ltd Elsevier 2024 Article PeerReviewed Whba, Fathyah and Mohamed, Faizal and Whba, Rawdah and Idris, Mohd Idzat and Mohd Noor, Noramaliza and Mahmood, Mohamad Khiari (2024) Synthesis and characterization of cellulose nanocrystals/Gd2O3 nanocomposite as a dual-mode contrast agent for MRI via gamma-ray irradiation. Radiation Physics and Chemistry, 221. art. no. 111727. ISSN 0969-806X; eISSN: 1879-0895 https://www.sciencedirect.com/science/article/abs/pii/S0969806X24002196?via%3Dihub 10.1016/j.radphyschem.2024.111727 |
| spellingShingle | Whba, Fathyah Mohamed, Faizal Whba, Rawdah Idris, Mohd Idzat Mohd Noor, Noramaliza Mahmood, Mohamad Khiari Synthesis and characterization of cellulose nanocrystals/Gd2O3 nanocomposite as a dual-mode contrast agent for MRI via gamma-ray irradiation |
| title | Synthesis and characterization of cellulose nanocrystals/Gd2O3 nanocomposite as a dual-mode contrast agent for MRI via gamma-ray irradiation |
| title_full | Synthesis and characterization of cellulose nanocrystals/Gd2O3 nanocomposite as a dual-mode contrast agent for MRI via gamma-ray irradiation |
| title_fullStr | Synthesis and characterization of cellulose nanocrystals/Gd2O3 nanocomposite as a dual-mode contrast agent for MRI via gamma-ray irradiation |
| title_full_unstemmed | Synthesis and characterization of cellulose nanocrystals/Gd2O3 nanocomposite as a dual-mode contrast agent for MRI via gamma-ray irradiation |
| title_short | Synthesis and characterization of cellulose nanocrystals/Gd2O3 nanocomposite as a dual-mode contrast agent for MRI via gamma-ray irradiation |
| title_sort | synthesis and characterization of cellulose nanocrystals/gd2o3 nanocomposite as a dual-mode contrast agent for mri via gamma-ray irradiation |
| url | http://psasir.upm.edu.my/id/eprint/112790/ http://psasir.upm.edu.my/id/eprint/112790/ http://psasir.upm.edu.my/id/eprint/112790/ |