Limonoids from the fruits of Chisocheton erythrocarpus and their mosquito larvicidal activities
Phytochemical study of the fruits of Chisocheton erythrocarpus (Hiern) allowed the identification of eight undescribed limonoids, namely erythrocarpines O – V (1–6, 7a and 7b), along with seven known compounds. The structures of these compounds were elucidated based on spectroscopic and HRMS data, a...
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| Format: | Article |
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Elsevier
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/112769/ |
| _version_ | 1848866031550857216 |
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| author | Ngadni, Muhammad Afiq Chong, Soon-Lim Hazni, Hazrina Asib, Norhayu Ishak, Intan Haslina Mohmad Misnan, Norazlan Supratman, Unang Awang, Khalijah |
| author_facet | Ngadni, Muhammad Afiq Chong, Soon-Lim Hazni, Hazrina Asib, Norhayu Ishak, Intan Haslina Mohmad Misnan, Norazlan Supratman, Unang Awang, Khalijah |
| author_sort | Ngadni, Muhammad Afiq |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Phytochemical study of the fruits of Chisocheton erythrocarpus (Hiern) allowed the identification of eight undescribed limonoids, namely erythrocarpines O – V (1–6, 7a and 7b), along with seven known compounds. The structures of these compounds were elucidated based on spectroscopic and HRMS data, along with electronic circular dichroism to configure the absolute configuration. Erythrocarpines O and P are γ-hydroxybutenolide analogs of mexicanolide-type limonoids while erythrocarpine Q – V are phragmalin-type limonoids possessing a 1,29-oxymethylene bridge with either benzoyl or cinnamoyl moiety in their structures. Mosquito larvicidal activity revealed that crude DCM extract of C. erythrocarpus possessed a good larvicidal effect against Aedes aegypti larvae in 48 h (LC50 = 153.0 ppm). Subsequent larvicidal activity of isolated compounds indicated that erythrocarpine G (10) and 14-deoxyxyloccensin K (11) were responsible for the enhanced larvicidal effect of the extract, reporting LC50 values of 18.55 ppm and 41.16 ppm, respectively. Moreover, residual activity testing of the crude DCM extract revealed that the duration of its larvicidal effects is up to 14 days, where it maintained a 98 % larval mortality throughout the test period, under laboratory conditions. |
| first_indexed | 2025-11-15T14:14:08Z |
| format | Article |
| id | upm-112769 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T14:14:08Z |
| publishDate | 2024 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1127692024-11-12T07:30:19Z http://psasir.upm.edu.my/id/eprint/112769/ Limonoids from the fruits of Chisocheton erythrocarpus and their mosquito larvicidal activities Ngadni, Muhammad Afiq Chong, Soon-Lim Hazni, Hazrina Asib, Norhayu Ishak, Intan Haslina Mohmad Misnan, Norazlan Supratman, Unang Awang, Khalijah Phytochemical study of the fruits of Chisocheton erythrocarpus (Hiern) allowed the identification of eight undescribed limonoids, namely erythrocarpines O – V (1–6, 7a and 7b), along with seven known compounds. The structures of these compounds were elucidated based on spectroscopic and HRMS data, along with electronic circular dichroism to configure the absolute configuration. Erythrocarpines O and P are γ-hydroxybutenolide analogs of mexicanolide-type limonoids while erythrocarpine Q – V are phragmalin-type limonoids possessing a 1,29-oxymethylene bridge with either benzoyl or cinnamoyl moiety in their structures. Mosquito larvicidal activity revealed that crude DCM extract of C. erythrocarpus possessed a good larvicidal effect against Aedes aegypti larvae in 48 h (LC50 = 153.0 ppm). Subsequent larvicidal activity of isolated compounds indicated that erythrocarpine G (10) and 14-deoxyxyloccensin K (11) were responsible for the enhanced larvicidal effect of the extract, reporting LC50 values of 18.55 ppm and 41.16 ppm, respectively. Moreover, residual activity testing of the crude DCM extract revealed that the duration of its larvicidal effects is up to 14 days, where it maintained a 98 % larval mortality throughout the test period, under laboratory conditions. Elsevier 2024 Article PeerReviewed Ngadni, Muhammad Afiq and Chong, Soon-Lim and Hazni, Hazrina and Asib, Norhayu and Ishak, Intan Haslina and Mohmad Misnan, Norazlan and Supratman, Unang and Awang, Khalijah (2024) Limonoids from the fruits of Chisocheton erythrocarpus and their mosquito larvicidal activities. Phytochemistry, 222. art. no. 114092. pp. 1-12. ISSN 0031-9422 https://www.sciencedirect.com/science/article/abs/pii/S0031942224001298?via%3Dihub 10.1016/j.phytochem.2024.114092 |
| spellingShingle | Ngadni, Muhammad Afiq Chong, Soon-Lim Hazni, Hazrina Asib, Norhayu Ishak, Intan Haslina Mohmad Misnan, Norazlan Supratman, Unang Awang, Khalijah Limonoids from the fruits of Chisocheton erythrocarpus and their mosquito larvicidal activities |
| title | Limonoids from the fruits of Chisocheton erythrocarpus and their mosquito larvicidal activities |
| title_full | Limonoids from the fruits of Chisocheton erythrocarpus and their mosquito larvicidal activities |
| title_fullStr | Limonoids from the fruits of Chisocheton erythrocarpus and their mosquito larvicidal activities |
| title_full_unstemmed | Limonoids from the fruits of Chisocheton erythrocarpus and their mosquito larvicidal activities |
| title_short | Limonoids from the fruits of Chisocheton erythrocarpus and their mosquito larvicidal activities |
| title_sort | limonoids from the fruits of chisocheton erythrocarpus and their mosquito larvicidal activities |
| url | http://psasir.upm.edu.my/id/eprint/112769/ http://psasir.upm.edu.my/id/eprint/112769/ http://psasir.upm.edu.my/id/eprint/112769/ |