Antifungal garcinia acid esters from the fruits of garcinia atroviridis
Two new garcinia acid derivatives, 2-(butoxycarbonylmethyl)-3-butoxycarbonyl-2-hydroxy3-propanolide and 1′,1″-dibutyl methyl hydroxycitrate, were isolated from the fruits of Garcinia atroviridis guided by TLC bioautography against the fungus Cladosporium herbarum. The structures of these compounds w...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2002
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| Online Access: | http://psasir.upm.edu.my/id/eprint/112496/ http://psasir.upm.edu.my/id/eprint/112496/3/112496.pdf |
| _version_ | 1848865958111739904 |
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| author | Mackeen, Mukram M. Ali, Abdul Manaf Lajis, Nordin Kawazu, Kazuyoshi Kikuzaki, Hiroe Nakatani, Nobuji |
| author_facet | Mackeen, Mukram M. Ali, Abdul Manaf Lajis, Nordin Kawazu, Kazuyoshi Kikuzaki, Hiroe Nakatani, Nobuji |
| author_sort | Mackeen, Mukram M. |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Two new garcinia acid derivatives, 2-(butoxycarbonylmethyl)-3-butoxycarbonyl-2-hydroxy3-propanolide and 1′,1″-dibutyl methyl hydroxycitrate, were isolated from the fruits of Garcinia atroviridis guided by TLC bioautography against the fungus Cladosporium herbarum. The structures of these compounds were established by spectral analysis. The former compound represents a unique β-lactone structure and the latter compound is most likely an artefact of garcinia acid (= hydroxycitric acid). Both compounds showed selective antifungal activity comparable to that of cycloheximide (MID: 0.5 μg/spot) only against C. herbarum at the MIDs of 0.4 and 0.8 μg/spot but were inactive against bacteria (Bacillus subtilis, methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli), other fungi (Alternaria sp., Fusarium moniliforme and Aspergillus ochraceous) including the yeast Candida albicans. |
| first_indexed | 2025-11-15T14:12:58Z |
| format | Article |
| id | upm-112496 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:12:58Z |
| publishDate | 2002 |
| publisher | De Gruyter |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1124962025-03-06T07:16:59Z http://psasir.upm.edu.my/id/eprint/112496/ Antifungal garcinia acid esters from the fruits of garcinia atroviridis Mackeen, Mukram M. Ali, Abdul Manaf Lajis, Nordin Kawazu, Kazuyoshi Kikuzaki, Hiroe Nakatani, Nobuji Two new garcinia acid derivatives, 2-(butoxycarbonylmethyl)-3-butoxycarbonyl-2-hydroxy3-propanolide and 1′,1″-dibutyl methyl hydroxycitrate, were isolated from the fruits of Garcinia atroviridis guided by TLC bioautography against the fungus Cladosporium herbarum. The structures of these compounds were established by spectral analysis. The former compound represents a unique β-lactone structure and the latter compound is most likely an artefact of garcinia acid (= hydroxycitric acid). Both compounds showed selective antifungal activity comparable to that of cycloheximide (MID: 0.5 μg/spot) only against C. herbarum at the MIDs of 0.4 and 0.8 μg/spot but were inactive against bacteria (Bacillus subtilis, methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli), other fungi (Alternaria sp., Fusarium moniliforme and Aspergillus ochraceous) including the yeast Candida albicans. De Gruyter 2002 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/112496/3/112496.pdf Mackeen, Mukram M. and Ali, Abdul Manaf and Lajis, Nordin and Kawazu, Kazuyoshi and Kikuzaki, Hiroe and Nakatani, Nobuji (2002) Antifungal garcinia acid esters from the fruits of garcinia atroviridis. Zeitschrift für Naturforschung C, 57 (3-4). pp. 291-295. ISSN 0939-5075; eISSN: 1865-7125 https://www.degruyter.com/document/doi/10.1515/znc-2002-3-416/html 10.1515/znc-2002-3-416 |
| spellingShingle | Mackeen, Mukram M. Ali, Abdul Manaf Lajis, Nordin Kawazu, Kazuyoshi Kikuzaki, Hiroe Nakatani, Nobuji Antifungal garcinia acid esters from the fruits of garcinia atroviridis |
| title | Antifungal garcinia acid esters from the fruits of garcinia atroviridis |
| title_full | Antifungal garcinia acid esters from the fruits of garcinia atroviridis |
| title_fullStr | Antifungal garcinia acid esters from the fruits of garcinia atroviridis |
| title_full_unstemmed | Antifungal garcinia acid esters from the fruits of garcinia atroviridis |
| title_short | Antifungal garcinia acid esters from the fruits of garcinia atroviridis |
| title_sort | antifungal garcinia acid esters from the fruits of garcinia atroviridis |
| url | http://psasir.upm.edu.my/id/eprint/112496/ http://psasir.upm.edu.my/id/eprint/112496/ http://psasir.upm.edu.my/id/eprint/112496/ http://psasir.upm.edu.my/id/eprint/112496/3/112496.pdf |