Preliminary insight on diarylpentanoids as potential antimalarials: In silico, in vitro pLDH and in vivo zebrafish toxicity assessment

QR Code

Preliminary insight on diarylpentanoids as potential antimalarials: In silico, in vitro pLDH and in vivo zebrafish toxicity assessment

Malaria remains a major public health problem worldwide, including in Southeast Asia. Chemotherapeutic agents such as chloroquine (CQ) are effective, but problems with drug resistance and toxicity have necessitated a continuous search for new effective antimalarial agents. Here we report on a virtua...

Full description

Bibliographic Details
Main Authors:	Ramli, Amirah Hani, Swain, Puspanjali, Mohd Fahmi, Muhammad Syafiq Akmal, Abas, Faridah, Leong, Sze Wei, Tejo, Bimo Ario, Shaari, Khozirah, Ali, Amatul Hamizah, Agustar, Hani Kartini, Awang, Rusdam, Ng, Yee Ling, Lau, Yee Ling, Md Razali, Mohammad Aidiel, Mastuki, Siti Nurulhuda, Mohmad Misnan, Norazlan, Mohd Faudzi, Siti Munirah, Kim, Cheol-Hee
Format:	Article
Language:	English
Published:	Elsevier 2024
Online Access:	http://psasir.upm.edu.my/id/eprint/112060/ http://psasir.upm.edu.my/id/eprint/112060/1/PIIS2405844024034935.pdf

Similar Items

Synthesis, antimalarial activity, and molecular dynamic approaches of salophen metal complexes
by: Ali, Amatul Hamizah, et al.
Published: (2024)

Reductive Alkylation of Candida Rugosa Lipase: Structural Approaches
by: Tejo, Bimo Ario
Published: (2004)

Tak gopoh dapatkan vaksin COVID-19 demi kemaslahatan
by: Tejo, Bimo Ario
Published: (2020)

Perketat kawalan sempadan, dos penggalak 'perisai' kukuh negara
by: Tejo, Bimo Ario
Published: (2023)

Sudah tiba masa Malaysia cipta sendiri ubat antiviral baharu
by: Tejo, Bimo Ario
Published: (2022)

Synthesis, biological evaluation and QSAR studies of diarylpentanoid analogues as potential nitric oxideinhibitors
by: Mohd Faudzi, Siti Munirah Mohd Faudzi, et al.
Published: (2015)

Identification of the anti-epileptic effect of speciogynine through molecular network-aided metabolite profiling of M. speciosa alkaloids using zebrafish
by: Garba, Suleiman Abubakar, et al.
Published: (2025)

Molecular pathways modulated by curcumin analogue, diarylpentanoids in cancer
by: Paulraj, Felicia Simone, et al.
Published: (2019)

Synthesis and sar study of diarylpentanoid analogues as new anti-inflammatory agents
by: Leong, Sze Wei, et al.
Published: (2014)

Synthesis and SAR study of diarylpentanoid analogues as new anti-inflammatory agents
by: Leong, Sze Wei, et al.
Published: (2014)

The antimalarial effect of curcumin is mediated by the inhibition of glycogen synthase kinase-3β
by: Ali, Amatul Hamizah, et al.
Published: (2017)

Solution structure of a novel T-cell adhesion inhibitor derived from the fragment of ICAM-1 receptor: cyclo(1,8)-Cys-Pro-Arg-Gly-Gly-Ser-Val-Cys
by: Tejo, Bimo Ario, et al.
Published: (2009)

In vitro and in silico evaluations of diarylpentanoid series as a-glucosidase inhibitor
by: Leong, Sze Wei, et al.
Published: (2018)

In silico studies, X-ray diffraction analysis and biological investigation of fluorinated pyrrolylated-chalcones in zebrafish epilepsy models
by: Muhammad Syafiq, Akmal Mohd Fahmi, et al.
Published: (2023)

In silico studies, X-ray diffraction analysis and biological investigation of fluorinated pyrrolylated-chalcones in zebrafish epilepsy models
by: Mohd Fahmi, Muhammad Syafiq Akmal, et al.
Published: (2023)

Lactate dehydrogenase (LDH) levels in serum and synovial fluid of dogs
by: R., Zurina, et al.
Published: (1999)

Clinical Pharmacology Of Antimalarial Drugs.
Published: (1989)

Effect of diarylpentanoid analogues on lipopolysaccharide-induced interleukin-6 and interleukin-8 gene expression in airway inflammation
by: Liew, Kong Yen, et al.
Published: (2019)

A synthetic curcumin-like diarylpentanoid analog inhibits rhinovirus infection in H1 hela cells via multiple antiviral mechanisms
by: Liew, Kong Yen, et al.
Published: (2024)

A facile green synthesis of LDH nanosheets using sugar molecules
by: Abdul Latip, Ahmad Faiz, et al.
Published: (2024)

The synthesis of the antimalarial compound hydroxypiperaquine (HPQ)
by: Mohammed, Yousuf Hussain
Published: (2007)

Pharmacokinetics and allometric scaling of antimalarial drugs
by: Senarathna, Senarathna Mudiyanselage Dona Kalyani Ganga
Published: (2015)

Identification Of Antimalarial Compounds And Their Mode Of Actions
by: Mahmud, Fauze
Published: (2022)

Taburan parasit anura dan indeks kualiti air di kawasan tasik dan Tanah Bencah Putrajaya
by: Hani Kartini Agustar,, et al.
Published: (2022)

Structure and dynamics of Candida rugosa lipase: the role of organic solvent
by: Tejo, Bimo Ario, et al.
Published: (2004)

Atomic absorption spectroscopy for determination of some mineral contents in selected fruits consumed by BSAC students / Norazlan Mohmad Misnan
by: Mohmad Misnan, Norazlan
Published: (2009)

Removal of CR(VI) in wastewater by MN/AL-LDH and its modified materials
by: Xie, Chengrui
Published: (2020)

Synthesis, biological evaluation and QSAR studies of diarylpentanoid analogues as potential nitric oxide inhibitors
by: Mohd Faudzi, S. M., et al.
Published: (2015)

Medicinal plants with antimalarial activities mediated via glycogen synthase kinase-3 beta (GSK3β) inhibition
by: Hassan, Wan Rozianoor Mohd, et al.
Published: (2022)

The candidate antimalarial drug MMV665909 causes oxygen-dependent mRNA mistranslation and synergises with quinoline-derived antimalarials
by: Vallieres, Cindy, et al.
Published: (2017)

Synthesis, antimalarial activities of secondary amine-substituted eugenol compounds against plasmodium falciparum and in silico molecular docking analysis
by: Syahri, Jufrizal, et al.
Published: (2023)

Antimalarial activity of Neopetrosia exigua extract in mice
by: Abdillah, Syamsudin, et al.
Published: (2013)

Synthesis and antimalarial evaluation of novel isocryptolepine derivatives
by: Whittell, Louise, et al.
Published: (2011)

An immunoinformatic approach for identifying and designing conserved multi-epitope vaccines for coronaviruses
by: Ong, Yu Chuan, et al.
Published: (2024)

Synthesis and characterization of ZnAlCO₃₋ layered double hydroxide (LDH) / Zaiton Ruslan
by: Ruslan, Zaiton
Published: (2009)

Degradability enhancement of poly(lactic acid) by stearate-Zn3Al LDH nanolayers
by: Eili, Mahboobeh, et al.
Published: (2012)

The antimalarial drug quinine interferes with serotonin biosynthesis and action
by: Islahudin, Farida, et al.
Published: (2014)

Role of P-glycoprotein in absorption of novel antimalarial drugs
by: Crowe, Andrew, et al.
Published: (2006)

Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities
by: Ka-Heng, Lee, et al.
Published: (2009)

Design, synthesis, anti-inflammatory activity evaluation, and structure-activities relationship (SAR) study of diarylpentanoid derivatives
by: Leong, Sze Wei
Published: (2014)