MPTP- induced Balb/c mice recapitulate compensatory Parkinson’s-like motor features
This study aimed to assess motor responses and associated pathological changes caused by MPTP neurotoxicity in Balb/c mice. Male mice (13 weeks old, 25-30 g) were divided into four groups and received intraperitoneal injections of normal saline or different doses of MPTP-HCl for five consecutive day...
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/112053/ http://psasir.upm.edu.my/id/eprint/112053/1/5.pdf |
| _version_ | 1848865843194101760 |
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| author | Mustapha, Musa Mat Taib, Che Norma Fakurazi, Sharida Mohd Moklas, Mohamad Aris |
| author_facet | Mustapha, Musa Mat Taib, Che Norma Fakurazi, Sharida Mohd Moklas, Mohamad Aris |
| author_sort | Mustapha, Musa |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | This study aimed to assess motor responses and associated pathological changes caused by MPTP neurotoxicity in Balb/c mice. Male mice (13 weeks old, 25-30 g) were divided into four groups and received intraperitoneal injections of normal saline or different doses of MPTP-HCl for five consecutive days. Body weight was monitored, and behavioral tests were conducted. Histological examination with H&E staining was performed on the striatum and substantia nigra. Contrary to expectations, MPTP-treated mice showed increased locomotor activity in the open field test, covering a greater distance and exhibiting more rearing compared to control mice (p<0.05). The catalepsy test also showed lower catalepsy scores in the MPTP-treated group (p<0.05). However, the pole test did not indicate the presence of MPTP-induced bradykinesia (p>0.05). Similarly, the traction and hang tests showed no significant effects of MPTP on motor balance or muscle strength (p>0.05). Among the MPTP-treated groups, the 30 mg/kg MPTP-HCl group displayed the most severe pathological changes, including reactive gliosis, as observed in histological examination. In conclusion, the subacute MPTP mouse model used in this study did not exhibit noticeable motor deficits or significant weight loss in Balb/c mice, possibly due to subthreshold dopamine depletion compensatory mechanisms. This model could provide valuable insights into the compensatory mechanisms involved in Parkinson’s disease. © 2024 Penerbit Universiti Kebangsaan Malaysia. All rights reserved. |
| first_indexed | 2025-11-15T14:11:09Z |
| format | Article |
| id | upm-112053 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:11:09Z |
| publishDate | 2024 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1120532024-10-28T03:43:32Z http://psasir.upm.edu.my/id/eprint/112053/ MPTP- induced Balb/c mice recapitulate compensatory Parkinson’s-like motor features Mustapha, Musa Mat Taib, Che Norma Fakurazi, Sharida Mohd Moklas, Mohamad Aris This study aimed to assess motor responses and associated pathological changes caused by MPTP neurotoxicity in Balb/c mice. Male mice (13 weeks old, 25-30 g) were divided into four groups and received intraperitoneal injections of normal saline or different doses of MPTP-HCl for five consecutive days. Body weight was monitored, and behavioral tests were conducted. Histological examination with H&E staining was performed on the striatum and substantia nigra. Contrary to expectations, MPTP-treated mice showed increased locomotor activity in the open field test, covering a greater distance and exhibiting more rearing compared to control mice (p<0.05). The catalepsy test also showed lower catalepsy scores in the MPTP-treated group (p<0.05). However, the pole test did not indicate the presence of MPTP-induced bradykinesia (p>0.05). Similarly, the traction and hang tests showed no significant effects of MPTP on motor balance or muscle strength (p>0.05). Among the MPTP-treated groups, the 30 mg/kg MPTP-HCl group displayed the most severe pathological changes, including reactive gliosis, as observed in histological examination. In conclusion, the subacute MPTP mouse model used in this study did not exhibit noticeable motor deficits or significant weight loss in Balb/c mice, possibly due to subthreshold dopamine depletion compensatory mechanisms. This model could provide valuable insights into the compensatory mechanisms involved in Parkinson’s disease. © 2024 Penerbit Universiti Kebangsaan Malaysia. All rights reserved. Penerbit Universiti Kebangsaan Malaysia 2024 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/112053/1/5.pdf Mustapha, Musa and Mat Taib, Che Norma and Fakurazi, Sharida and Mohd Moklas, Mohamad Aris (2024) MPTP- induced Balb/c mice recapitulate compensatory Parkinson’s-like motor features. Sains Malaysiana, 53 (1). pp. 49-61. ISSN 0126-6039 https://www.ukm.my/jsm/pdf_files/SM-PDF-53-1-2024/5.pdf 10.17576/jsm-2024-5301-05 |
| spellingShingle | Mustapha, Musa Mat Taib, Che Norma Fakurazi, Sharida Mohd Moklas, Mohamad Aris MPTP- induced Balb/c mice recapitulate compensatory Parkinson’s-like motor features |
| title | MPTP- induced Balb/c mice recapitulate compensatory Parkinson’s-like motor features |
| title_full | MPTP- induced Balb/c mice recapitulate compensatory Parkinson’s-like motor features |
| title_fullStr | MPTP- induced Balb/c mice recapitulate compensatory Parkinson’s-like motor features |
| title_full_unstemmed | MPTP- induced Balb/c mice recapitulate compensatory Parkinson’s-like motor features |
| title_short | MPTP- induced Balb/c mice recapitulate compensatory Parkinson’s-like motor features |
| title_sort | mptp- induced balb/c mice recapitulate compensatory parkinson’s-like motor features |
| url | http://psasir.upm.edu.my/id/eprint/112053/ http://psasir.upm.edu.my/id/eprint/112053/ http://psasir.upm.edu.my/id/eprint/112053/ http://psasir.upm.edu.my/id/eprint/112053/1/5.pdf |