Cytotoxicity and electron microscopy of cell death induced by goniothalamin
The cytotoxicity of goniothalamin was found to be strong towards both cancerous (HGC-27, MCF-7, PANC-1, HeLa), and non-cancerous (3T3) cell lines, especially in cases of dividing cells. Drug exposure studies indicated that the cytotoxic action of goniothalamin was time- and dose-dependent. At the ul...
| Main Authors: | , , , , , , |
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| Format: | Article |
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Georg Thieme Verlag KG
1997
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| Online Access: | http://psasir.upm.edu.my/id/eprint/111947/ |
| _version_ | 1848865819501527040 |
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| author | Ali, A. McKeen, M. Hamid, M. Aun, Q. Zauyah, Y. Azimahtol, H. Kawazu, K. |
| author_facet | Ali, A. McKeen, M. Hamid, M. Aun, Q. Zauyah, Y. Azimahtol, H. Kawazu, K. |
| author_sort | Ali, A. |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The cytotoxicity of goniothalamin was found to be strong towards both cancerous (HGC-27, MCF-7, PANC-1, HeLa), and non-cancerous (3T3) cell lines, especially in cases of dividing cells. Drug exposure studies indicated that the cytotoxic action of goniothalamin was time- and dose-dependent. At the ultra-structural level, goniothalamin-induced cytotoxicity revealed a necrotic mode of cell death towards MCF-7 cells. |
| first_indexed | 2025-11-15T14:10:46Z |
| format | Article |
| id | upm-111947 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T14:10:46Z |
| publishDate | 1997 |
| publisher | Georg Thieme Verlag KG |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1119472025-03-03T01:33:04Z http://psasir.upm.edu.my/id/eprint/111947/ Cytotoxicity and electron microscopy of cell death induced by goniothalamin Ali, A. McKeen, M. Hamid, M. Aun, Q. Zauyah, Y. Azimahtol, H. Kawazu, K. The cytotoxicity of goniothalamin was found to be strong towards both cancerous (HGC-27, MCF-7, PANC-1, HeLa), and non-cancerous (3T3) cell lines, especially in cases of dividing cells. Drug exposure studies indicated that the cytotoxic action of goniothalamin was time- and dose-dependent. At the ultra-structural level, goniothalamin-induced cytotoxicity revealed a necrotic mode of cell death towards MCF-7 cells. Georg Thieme Verlag KG 1997 Article PeerReviewed Ali, A. and McKeen, M. and Hamid, M. and Aun, Q. and Zauyah, Y. and Azimahtol, H. and Kawazu, K. (1997) Cytotoxicity and electron microscopy of cell death induced by goniothalamin. Planta Medica, 63 (1). pp. 81-83. ISSN 0032-0943; eISSN: 1439-0221 https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-2006-957611 10.1055/s-2006-957611 |
| spellingShingle | Ali, A. McKeen, M. Hamid, M. Aun, Q. Zauyah, Y. Azimahtol, H. Kawazu, K. Cytotoxicity and electron microscopy of cell death induced by goniothalamin |
| title | Cytotoxicity and electron microscopy of cell death induced by goniothalamin |
| title_full | Cytotoxicity and electron microscopy of cell death induced by goniothalamin |
| title_fullStr | Cytotoxicity and electron microscopy of cell death induced by goniothalamin |
| title_full_unstemmed | Cytotoxicity and electron microscopy of cell death induced by goniothalamin |
| title_short | Cytotoxicity and electron microscopy of cell death induced by goniothalamin |
| title_sort | cytotoxicity and electron microscopy of cell death induced by goniothalamin |
| url | http://psasir.upm.edu.my/id/eprint/111947/ http://psasir.upm.edu.my/id/eprint/111947/ http://psasir.upm.edu.my/id/eprint/111947/ |