In vitro anti-inflammatory and wound healing properties of defatted Selenicereus monacanthus (Lem.) D.R.Hunt seed extract
Extracts from Selenicereus monacanthus (synonym: Hylocereus polyrhizus) have received attention due to their potent anti-inflammatory, antioxidant, anticancer, and antidiabetic properties. The current study aims to determine the anti-inflammatory and wound-healing potential of defatted S. monacanthu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor and Francis Ltd.
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/111540/ http://psasir.upm.edu.my/id/eprint/111540/1/In%20vitro%20anti-inflammatory%20and%20wound%20healing%20properties%20of%20defatted%20Selenicereus%20monacanthus%20%20Lem.%20%20D.R.Hunt%20seed%20extract%20%281%29.pdf |
| _version_ | 1848865715311869952 |
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| author | Zulkifli, Siti Atikah Abd Gani, Siti Salwa Zaidan, Uswatun Hasanah Misran, Azizah Hassan, Masriana |
| author_facet | Zulkifli, Siti Atikah Abd Gani, Siti Salwa Zaidan, Uswatun Hasanah Misran, Azizah Hassan, Masriana |
| author_sort | Zulkifli, Siti Atikah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Extracts from Selenicereus monacanthus (synonym: Hylocereus polyrhizus) have received attention due to their potent anti-inflammatory, antioxidant, anticancer, and antidiabetic properties. The current study aims to determine the anti-inflammatory and wound-healing potential of defatted S. monacanthus seed extract (DSMSE). Anti-inflammatory properties of DSMSE on LPS-induced inflammation on THP-1 were determined by measuring the levels of interleukins IL-6, IL-8, and IL-10. Wound healing scratch assay was performed using the human fibroblast (Hs27) cell that assesses the cell migration over 24 h exposure
to DSMSE. Administration of DSMSE significantly reduced the
LPS-stimulated release levels of IL-6 and IL-8 and significantly increased the levels of IL-10. Treatment with DSMSE showed a significant increase in wound closure with 70% of fibroblast migration. Therefore, the current study showed the anti-inflammatory and wound healing properties of DSMSE reducing inflammatory cytokines (IL-6 and IL-8), increasing IL-10 cytokine, and increasing wound closure at 24 h. |
| first_indexed | 2025-11-15T14:09:07Z |
| format | Article |
| id | upm-111540 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:09:07Z |
| publishDate | 2024 |
| publisher | Taylor and Francis Ltd. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1115402024-08-04T08:53:01Z http://psasir.upm.edu.my/id/eprint/111540/ In vitro anti-inflammatory and wound healing properties of defatted Selenicereus monacanthus (Lem.) D.R.Hunt seed extract Zulkifli, Siti Atikah Abd Gani, Siti Salwa Zaidan, Uswatun Hasanah Misran, Azizah Hassan, Masriana Extracts from Selenicereus monacanthus (synonym: Hylocereus polyrhizus) have received attention due to their potent anti-inflammatory, antioxidant, anticancer, and antidiabetic properties. The current study aims to determine the anti-inflammatory and wound-healing potential of defatted S. monacanthus seed extract (DSMSE). Anti-inflammatory properties of DSMSE on LPS-induced inflammation on THP-1 were determined by measuring the levels of interleukins IL-6, IL-8, and IL-10. Wound healing scratch assay was performed using the human fibroblast (Hs27) cell that assesses the cell migration over 24 h exposure to DSMSE. Administration of DSMSE significantly reduced the LPS-stimulated release levels of IL-6 and IL-8 and significantly increased the levels of IL-10. Treatment with DSMSE showed a significant increase in wound closure with 70% of fibroblast migration. Therefore, the current study showed the anti-inflammatory and wound healing properties of DSMSE reducing inflammatory cytokines (IL-6 and IL-8), increasing IL-10 cytokine, and increasing wound closure at 24 h. Taylor and Francis Ltd. 2024-05-14 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/111540/1/In%20vitro%20anti-inflammatory%20and%20wound%20healing%20properties%20of%20defatted%20Selenicereus%20monacanthus%20%20Lem.%20%20D.R.Hunt%20seed%20extract%20%281%29.pdf Zulkifli, Siti Atikah and Abd Gani, Siti Salwa and Zaidan, Uswatun Hasanah and Misran, Azizah and Hassan, Masriana (2024) In vitro anti-inflammatory and wound healing properties of defatted Selenicereus monacanthus (Lem.) D.R.Hunt seed extract. Natural Product Research. pp. 1-9. ISSN 1478-6419; EISSN: 1478-6427 (In Press) https://www.tandfonline.com/doi/full/10.1080/14786419.2024.2344190 10.1080/14786419.2024.2344190 |
| spellingShingle | Zulkifli, Siti Atikah Abd Gani, Siti Salwa Zaidan, Uswatun Hasanah Misran, Azizah Hassan, Masriana In vitro anti-inflammatory and wound healing properties of defatted Selenicereus monacanthus (Lem.) D.R.Hunt seed extract |
| title | In vitro anti-inflammatory and wound healing properties of defatted Selenicereus monacanthus (Lem.) D.R.Hunt seed extract |
| title_full | In vitro anti-inflammatory and wound healing properties of defatted Selenicereus monacanthus (Lem.) D.R.Hunt seed extract |
| title_fullStr | In vitro anti-inflammatory and wound healing properties of defatted Selenicereus monacanthus (Lem.) D.R.Hunt seed extract |
| title_full_unstemmed | In vitro anti-inflammatory and wound healing properties of defatted Selenicereus monacanthus (Lem.) D.R.Hunt seed extract |
| title_short | In vitro anti-inflammatory and wound healing properties of defatted Selenicereus monacanthus (Lem.) D.R.Hunt seed extract |
| title_sort | in vitro anti-inflammatory and wound healing properties of defatted selenicereus monacanthus (lem.) d.r.hunt seed extract |
| url | http://psasir.upm.edu.my/id/eprint/111540/ http://psasir.upm.edu.my/id/eprint/111540/ http://psasir.upm.edu.my/id/eprint/111540/ http://psasir.upm.edu.my/id/eprint/111540/1/In%20vitro%20anti-inflammatory%20and%20wound%20healing%20properties%20of%20defatted%20Selenicereus%20monacanthus%20%20Lem.%20%20D.R.Hunt%20seed%20extract%20%281%29.pdf |