Metabolite alteration associated with Dabai pulp oil supplementation in hypercholesterolemic rats
Introduction: Metabolomic analyses have become paramount in unveiling the therapeutic capacities of bioactive agents. Dabai pulp oil (DPO) has emerged as a prospective agent against hypercholesterolemia. This investigation delineates the metabolic imprints of DPO’s therapeutic actions using 1H NMR-b...
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| Format: | Article |
| Language: | English |
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Universiti Putra Malaysia
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/111522/ http://psasir.upm.edu.my/id/eprint/111522/1/MJMHS_0879.pdf |
| _version_ | 1848865710339522560 |
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| author | Abdul Kadir, Noor Atiqah Aizan Azlan, Azrina Abdul Mutalib, Maisarah |
| author_facet | Abdul Kadir, Noor Atiqah Aizan Azlan, Azrina Abdul Mutalib, Maisarah |
| author_sort | Abdul Kadir, Noor Atiqah Aizan |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Introduction: Metabolomic analyses have become paramount in unveiling the therapeutic capacities of bioactive agents. Dabai pulp oil (DPO) has emerged as a prospective agent against hypercholesterolemia. This investigation delineates the metabolic imprints of DPO’s therapeutic actions using 1H NMR-based urinary metabolomic profiling. Methods: Male Sprague-Dawley rats were first exposed to a high-cholesterol regimen to simulate hypercholesterolemia. Following this induction, they were transitioned to a DPO-infused diet. The ensuing metabolic variations were tracked using 1H NMR-based urinary metabolomic analysis. Results: The metabolic landscape displayed discernible shifts post-DPO administration, underlining its therapeutic potential. There was a marked decrement in the concentrations of pivotal metabolites such as creatinine, succinate, pyruvate, acetate, TMAO, and choline (p<0.05). Notably, an augmented taurine concentration after DPO administration spotlighted the oil’s antioxidative and anti-inflammatory prowess (p<0.05). These observations underscore DPO’s proficiency in rectifying metabolic aberrations inherent to hypercholesterolemia, particularly affecting energy transduction and cardiovascular function. Conclusion: This empirical evidence bolsters the notion that DPO harbours potent therapeutic virtues for hypercholesterolemia amelioration. Nevertheless, in-depth explorations are quintessential to decoding its holistic therapeutic pathways, fortifying its role in future targeted interventions. |
| first_indexed | 2025-11-15T14:09:02Z |
| format | Article |
| id | upm-111522 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:09:02Z |
| publishDate | 2024 |
| publisher | Universiti Putra Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1115222024-07-29T08:22:11Z http://psasir.upm.edu.my/id/eprint/111522/ Metabolite alteration associated with Dabai pulp oil supplementation in hypercholesterolemic rats Abdul Kadir, Noor Atiqah Aizan Azlan, Azrina Abdul Mutalib, Maisarah Introduction: Metabolomic analyses have become paramount in unveiling the therapeutic capacities of bioactive agents. Dabai pulp oil (DPO) has emerged as a prospective agent against hypercholesterolemia. This investigation delineates the metabolic imprints of DPO’s therapeutic actions using 1H NMR-based urinary metabolomic profiling. Methods: Male Sprague-Dawley rats were first exposed to a high-cholesterol regimen to simulate hypercholesterolemia. Following this induction, they were transitioned to a DPO-infused diet. The ensuing metabolic variations were tracked using 1H NMR-based urinary metabolomic analysis. Results: The metabolic landscape displayed discernible shifts post-DPO administration, underlining its therapeutic potential. There was a marked decrement in the concentrations of pivotal metabolites such as creatinine, succinate, pyruvate, acetate, TMAO, and choline (p<0.05). Notably, an augmented taurine concentration after DPO administration spotlighted the oil’s antioxidative and anti-inflammatory prowess (p<0.05). These observations underscore DPO’s proficiency in rectifying metabolic aberrations inherent to hypercholesterolemia, particularly affecting energy transduction and cardiovascular function. Conclusion: This empirical evidence bolsters the notion that DPO harbours potent therapeutic virtues for hypercholesterolemia amelioration. Nevertheless, in-depth explorations are quintessential to decoding its holistic therapeutic pathways, fortifying its role in future targeted interventions. Universiti Putra Malaysia 2024-05 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/111522/1/MJMHS_0879.pdf Abdul Kadir, Noor Atiqah Aizan and Azlan, Azrina and Abdul Mutalib, Maisarah (2024) Metabolite alteration associated with Dabai pulp oil supplementation in hypercholesterolemic rats. Malaysian Journal of Medicine and Health Sciences, 20 (3). pp. 142-149. ISSN 16758544; EISSN: 26369346 https://medic.upm.edu.my/upload/dokumen/2024052916594419_MJMHS_0879.pdf 10.47836/mjmhs.20.3.20 |
| spellingShingle | Abdul Kadir, Noor Atiqah Aizan Azlan, Azrina Abdul Mutalib, Maisarah Metabolite alteration associated with Dabai pulp oil supplementation in hypercholesterolemic rats |
| title | Metabolite alteration associated with Dabai pulp oil supplementation in hypercholesterolemic rats |
| title_full | Metabolite alteration associated with Dabai pulp oil supplementation in hypercholesterolemic rats |
| title_fullStr | Metabolite alteration associated with Dabai pulp oil supplementation in hypercholesterolemic rats |
| title_full_unstemmed | Metabolite alteration associated with Dabai pulp oil supplementation in hypercholesterolemic rats |
| title_short | Metabolite alteration associated with Dabai pulp oil supplementation in hypercholesterolemic rats |
| title_sort | metabolite alteration associated with dabai pulp oil supplementation in hypercholesterolemic rats |
| url | http://psasir.upm.edu.my/id/eprint/111522/ http://psasir.upm.edu.my/id/eprint/111522/ http://psasir.upm.edu.my/id/eprint/111522/ http://psasir.upm.edu.my/id/eprint/111522/1/MJMHS_0879.pdf |