Antihyperlipidemic and hepatoprotective activity of extracts of Zingiber cassumunar rhizome, Aguazuma ulmifolia leaves, and their combination in high-fat diet-fed rats
Oxidative stress is related to several metabolic diseases, including hyperlipidemia. Previous studies have shown the antioxidant properties of Zingiber cassumunar rhizomes and Guazuma ulmifolia leaves. The objective of this study was to see how Z. cassumunar rhizomes, G. ulmifolia leaves extracts,...
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| Format: | Article |
| Language: | English |
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Poznań University of Life Sciences
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/111512/ http://psasir.upm.edu.my/id/eprint/111512/1/Antihyperlipidemic%20And%20Hepatoprotective%20Activity%20Of%20Extracts%20Of%20Zingiber%20Cassumunar%20Rhizome%2C%20Guazuma%20Ulmifolia%20Leaves%2C%20And%20Their%20Combination%20In%20High-Fat%20Diet-Fed%20Rats.pdf |
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| author | Mahfudh, Nurkhasanah Sulistyani, Nanik Kumalasari, Ika D. Hilal, Ananda K. Refliandi, Refliandi Othman, Fezah Zakaria, Zainul A. |
| author_facet | Mahfudh, Nurkhasanah Sulistyani, Nanik Kumalasari, Ika D. Hilal, Ananda K. Refliandi, Refliandi Othman, Fezah Zakaria, Zainul A. |
| author_sort | Mahfudh, Nurkhasanah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Oxidative stress is related to several metabolic diseases, including hyperlipidemia. Previous studies have
shown the antioxidant properties of Zingiber cassumunar rhizomes and Guazuma ulmifolia leaves. The objective of this study was to see how Z. cassumunar rhizomes, G. ulmifolia leaves extracts, and their combinations
affect antihyperlipidemic and hepatoprotective activity in a high-fat diet-fed (HFD) rat. The water extract of
Z. cassumunar rhizomes and G. ulmifolia leaves was evaporated in a freeze dryer to produce dry extracts. The
Wistar rats were assigned into six groups at random: normal, positive, negative, Z. cassumunar rhizome extract
at 400 mg/kg BW (ZC), G. ulmifolia leaf extract at 50 mg/kg BW (GU), and the combination of Z. cassumunar
rhizome extract and G. ulmifolia leaf extract at (350+50) mg/kg BW (ZC+GU). The rats were fed HFD for
28 days, and the treatment groups also received the extracts for the last 14 days. The study revealed that ZC,
GU, and ZC+GU significantly (p < 0.05) reduced the levels of cholesterol and triglyceride when compared to
the negative control. These treatments also showed a hepatoprotective effect by reducing the serum glutamic
pyruvate transaminase (SGPT) and histopathological observation. The conclusion of the study showed that
ZC, GU, and ZC+GU play an essential role in their antihyperlipidemic and hepatoprotective activities. |
| first_indexed | 2025-11-15T14:08:59Z |
| format | Article |
| id | upm-111512 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:08:59Z |
| publishDate | 2024 |
| publisher | Poznań University of Life Sciences |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1115122024-08-09T01:36:04Z http://psasir.upm.edu.my/id/eprint/111512/ Antihyperlipidemic and hepatoprotective activity of extracts of Zingiber cassumunar rhizome, Aguazuma ulmifolia leaves, and their combination in high-fat diet-fed rats Mahfudh, Nurkhasanah Sulistyani, Nanik Kumalasari, Ika D. Hilal, Ananda K. Refliandi, Refliandi Othman, Fezah Zakaria, Zainul A. Oxidative stress is related to several metabolic diseases, including hyperlipidemia. Previous studies have shown the antioxidant properties of Zingiber cassumunar rhizomes and Guazuma ulmifolia leaves. The objective of this study was to see how Z. cassumunar rhizomes, G. ulmifolia leaves extracts, and their combinations affect antihyperlipidemic and hepatoprotective activity in a high-fat diet-fed (HFD) rat. The water extract of Z. cassumunar rhizomes and G. ulmifolia leaves was evaporated in a freeze dryer to produce dry extracts. The Wistar rats were assigned into six groups at random: normal, positive, negative, Z. cassumunar rhizome extract at 400 mg/kg BW (ZC), G. ulmifolia leaf extract at 50 mg/kg BW (GU), and the combination of Z. cassumunar rhizome extract and G. ulmifolia leaf extract at (350+50) mg/kg BW (ZC+GU). The rats were fed HFD for 28 days, and the treatment groups also received the extracts for the last 14 days. The study revealed that ZC, GU, and ZC+GU significantly (p < 0.05) reduced the levels of cholesterol and triglyceride when compared to the negative control. These treatments also showed a hepatoprotective effect by reducing the serum glutamic pyruvate transaminase (SGPT) and histopathological observation. The conclusion of the study showed that ZC, GU, and ZC+GU play an essential role in their antihyperlipidemic and hepatoprotective activities. Poznań University of Life Sciences 2024-01 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/111512/1/Antihyperlipidemic%20And%20Hepatoprotective%20Activity%20Of%20Extracts%20Of%20Zingiber%20Cassumunar%20Rhizome%2C%20Guazuma%20Ulmifolia%20Leaves%2C%20And%20Their%20Combination%20In%20High-Fat%20Diet-Fed%20Rats.pdf Mahfudh, Nurkhasanah and Sulistyani, Nanik and Kumalasari, Ika D. and Hilal, Ananda K. and Refliandi, Refliandi and Othman, Fezah and Zakaria, Zainul A. (2024) Antihyperlipidemic and hepatoprotective activity of extracts of Zingiber cassumunar rhizome, Aguazuma ulmifolia leaves, and their combination in high-fat diet-fed rats. Acta Scientiarum Polonorum, Technologia Alimentaria, 23 (1). pp. 39-47. ISSN 1644-0730; EISSN: 1898-9594 https://www.food.actapol.net/pub/4_1_2024.pdf 10.17306/j.afs.001142 |
| spellingShingle | Mahfudh, Nurkhasanah Sulistyani, Nanik Kumalasari, Ika D. Hilal, Ananda K. Refliandi, Refliandi Othman, Fezah Zakaria, Zainul A. Antihyperlipidemic and hepatoprotective activity of extracts of Zingiber cassumunar rhizome, Aguazuma ulmifolia leaves, and their combination in high-fat diet-fed rats |
| title | Antihyperlipidemic and hepatoprotective activity of extracts of Zingiber cassumunar rhizome, Aguazuma ulmifolia leaves, and their combination in high-fat diet-fed rats |
| title_full | Antihyperlipidemic and hepatoprotective activity of extracts of Zingiber cassumunar rhizome, Aguazuma ulmifolia leaves, and their combination in high-fat diet-fed rats |
| title_fullStr | Antihyperlipidemic and hepatoprotective activity of extracts of Zingiber cassumunar rhizome, Aguazuma ulmifolia leaves, and their combination in high-fat diet-fed rats |
| title_full_unstemmed | Antihyperlipidemic and hepatoprotective activity of extracts of Zingiber cassumunar rhizome, Aguazuma ulmifolia leaves, and their combination in high-fat diet-fed rats |
| title_short | Antihyperlipidemic and hepatoprotective activity of extracts of Zingiber cassumunar rhizome, Aguazuma ulmifolia leaves, and their combination in high-fat diet-fed rats |
| title_sort | antihyperlipidemic and hepatoprotective activity of extracts of zingiber cassumunar rhizome, aguazuma ulmifolia leaves, and their combination in high-fat diet-fed rats |
| url | http://psasir.upm.edu.my/id/eprint/111512/ http://psasir.upm.edu.my/id/eprint/111512/ http://psasir.upm.edu.my/id/eprint/111512/ http://psasir.upm.edu.my/id/eprint/111512/1/Antihyperlipidemic%20And%20Hepatoprotective%20Activity%20Of%20Extracts%20Of%20Zingiber%20Cassumunar%20Rhizome%2C%20Guazuma%20Ulmifolia%20Leaves%2C%20And%20Their%20Combination%20In%20High-Fat%20Diet-Fed%20Rats.pdf |