Paederia foetida twig extract: a dual-purpose antidiabetic and antioxidant agent in high-fat diet-low dose streptozotocin rats
This study was conducted to determine the antidiabetic and antioxidant effect of Paederia foetida twigs in high-fat diet-low dose streptozotocin-induced Sprague Dawley rats to provide essential information for safe use in humans. Thirty-six male Sprague Dawley rats were acclimatized for a week, 6 we...
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| Format: | Article |
| Language: | English |
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AMG Transcend Association
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/110422/ http://psasir.upm.edu.my/id/eprint/110422/1/110422.pdf |
| _version_ | 1848867716290576384 |
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| author | Tan, Dai Chuan Omar, Norsuhana Kassim, Nur Kartinee Irfan, Muhammad Hamid, Muhajir Ismail, Intan Safinar Mohd Noh, Ain’ Sabreena Quek, Alexandra |
| author_facet | Tan, Dai Chuan Omar, Norsuhana Kassim, Nur Kartinee Irfan, Muhammad Hamid, Muhajir Ismail, Intan Safinar Mohd Noh, Ain’ Sabreena Quek, Alexandra |
| author_sort | Tan, Dai Chuan |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | This study was conducted to determine the antidiabetic and antioxidant effect of Paederia foetida twigs in high-fat diet-low dose streptozotocin-induced Sprague Dawley rats to provide essential information for safe use in humans. Thirty-six male Sprague Dawley rats were acclimatized for a week, 6 were assigned to normal control, and 30 were induced into obesity using a high-fat diet for 4 weeks. After the obesity induction, 24 of 30 obese rats were induced diabetes by 40mg/kg streptozotocin and further divided into diabetic control and three diabetic treated groups (50mg/kg, 100mg/kg P. foetida, and 300mg/kg metformin). In the sub-chronic study, P. foetida twigs extract and metformin were orally administered to the rats for 28 days. Repeated single oral administration of 50mg/kg P. foetida twigs extract on diabetic rats for 28 days revealed this dosage as the most effective in lowering blood glucose (27.2%), comparable to metformin (23.1%). Treatment with 50mg/kg P. foetida twigs extracts displayed significant antioxidant properties that reduce oxidative stress based on the protein carbonyl levels and exhibited clinical signs of hyperglycemia and oxidative stress marker. P. foetida supplementation and metformin both reversed the clinical manifestation of type 2 diabetes. |
| first_indexed | 2025-11-15T14:40:55Z |
| format | Article |
| id | upm-110422 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:40:55Z |
| publishDate | 2024 |
| publisher | AMG Transcend Association |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1104222025-09-18T08:24:19Z http://psasir.upm.edu.my/id/eprint/110422/ Paederia foetida twig extract: a dual-purpose antidiabetic and antioxidant agent in high-fat diet-low dose streptozotocin rats Tan, Dai Chuan Omar, Norsuhana Kassim, Nur Kartinee Irfan, Muhammad Hamid, Muhajir Ismail, Intan Safinar Mohd Noh, Ain’ Sabreena Quek, Alexandra This study was conducted to determine the antidiabetic and antioxidant effect of Paederia foetida twigs in high-fat diet-low dose streptozotocin-induced Sprague Dawley rats to provide essential information for safe use in humans. Thirty-six male Sprague Dawley rats were acclimatized for a week, 6 were assigned to normal control, and 30 were induced into obesity using a high-fat diet for 4 weeks. After the obesity induction, 24 of 30 obese rats were induced diabetes by 40mg/kg streptozotocin and further divided into diabetic control and three diabetic treated groups (50mg/kg, 100mg/kg P. foetida, and 300mg/kg metformin). In the sub-chronic study, P. foetida twigs extract and metformin were orally administered to the rats for 28 days. Repeated single oral administration of 50mg/kg P. foetida twigs extract on diabetic rats for 28 days revealed this dosage as the most effective in lowering blood glucose (27.2%), comparable to metformin (23.1%). Treatment with 50mg/kg P. foetida twigs extracts displayed significant antioxidant properties that reduce oxidative stress based on the protein carbonyl levels and exhibited clinical signs of hyperglycemia and oxidative stress marker. P. foetida supplementation and metformin both reversed the clinical manifestation of type 2 diabetes. AMG Transcend Association 2024 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/110422/1/110422.pdf Tan, Dai Chuan and Omar, Norsuhana and Kassim, Nur Kartinee and Irfan, Muhammad and Hamid, Muhajir and Ismail, Intan Safinar and Mohd Noh, Ain’ Sabreena and Quek, Alexandra (2024) Paederia foetida twig extract: a dual-purpose antidiabetic and antioxidant agent in high-fat diet-low dose streptozotocin rats. Letters in Applied NanoBioScience, 13 (3). art. no. 140. pp. 1-16. ISSN 2284-6808; eISSN: 2284-6808 http://nanobioletters.com/wp-content/uploads/2024/07/LIANBS133.140.pdf 10.33263/LIANBS133.140 |
| spellingShingle | Tan, Dai Chuan Omar, Norsuhana Kassim, Nur Kartinee Irfan, Muhammad Hamid, Muhajir Ismail, Intan Safinar Mohd Noh, Ain’ Sabreena Quek, Alexandra Paederia foetida twig extract: a dual-purpose antidiabetic and antioxidant agent in high-fat diet-low dose streptozotocin rats |
| title | Paederia foetida twig extract: a dual-purpose antidiabetic and antioxidant agent in high-fat diet-low dose streptozotocin rats |
| title_full | Paederia foetida twig extract: a dual-purpose antidiabetic and antioxidant agent in high-fat diet-low dose streptozotocin rats |
| title_fullStr | Paederia foetida twig extract: a dual-purpose antidiabetic and antioxidant agent in high-fat diet-low dose streptozotocin rats |
| title_full_unstemmed | Paederia foetida twig extract: a dual-purpose antidiabetic and antioxidant agent in high-fat diet-low dose streptozotocin rats |
| title_short | Paederia foetida twig extract: a dual-purpose antidiabetic and antioxidant agent in high-fat diet-low dose streptozotocin rats |
| title_sort | paederia foetida twig extract: a dual-purpose antidiabetic and antioxidant agent in high-fat diet-low dose streptozotocin rats |
| url | http://psasir.upm.edu.my/id/eprint/110422/ http://psasir.upm.edu.my/id/eprint/110422/ http://psasir.upm.edu.my/id/eprint/110422/ http://psasir.upm.edu.my/id/eprint/110422/1/110422.pdf |