Lycopene in feed as antioxidant and immuno-modulator improves broiler chickens performance under heat-stress conditions
Lycopene is a type of carotenoid pigment widely distributed in various plants and fruits, with tomatoes, carrots, and guava being the most abundant sources. Due to its high content of beneficial active components, lycopene has been used in medicine, where it is employed as a dietary additive for can...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023
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| Online Access: | http://psasir.upm.edu.my/id/eprint/110395/ http://psasir.upm.edu.my/id/eprint/110395/1/110395.pdf |
| _version_ | 1848865513340403712 |
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| author | Hidayat, Dalila Fadhila Mahendra, Mohamad Yusril Nur Kamaludeen, Juriah Pertiwi, Herinda |
| author_facet | Hidayat, Dalila Fadhila Mahendra, Mohamad Yusril Nur Kamaludeen, Juriah Pertiwi, Herinda |
| author_sort | Hidayat, Dalila Fadhila |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Lycopene is a type of carotenoid pigment widely distributed in various plants and fruits, with tomatoes, carrots, and guava being the most abundant sources. Due to its high content of beneficial active components, lycopene has been used in medicine, where it is employed as a dietary additive for cancer therapy, immune modulator, and feed additive to improve livestock productivity. Lycopene is a lipophilic substance that can act as either a prooxidant or a free radical scavenger and is particularly efficient in enhancing broiler performance. Furthermore, lycopene can alleviate heat stress by improving the activity of various antioxidant enzymes such as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT), as well as increasing the total antioxidant capacity (T-AOC) and nuclear muscle factor erythroid 2-related factor 2 (Nrf2), while simultaneously reducing the levels of malondialdehyde (MDA) and muscle Keap1 expression. In addition, lycopene can improve broiler fertility by enhancing sperm performance and reducing inflammation by modulating the levels of interleukin 1, 2, and 10 (IL-1, IL-2, and IL-10) in cases of infection. In cases of disease by aflatoxin B1 (AFB1), lycopene can modulate interferon-γ (IFN-γ), IL-1, claudin-1 (CLDN-1), and zonula occludens-1 (ZO-1). Furthermore, under the lipopolysaccharide challenge, lycopene can increase the relative weights of immune organ indices such as the bursal, spleen, and thymus. |
| first_indexed | 2025-11-15T14:05:54Z |
| format | Article |
| id | upm-110395 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:05:54Z |
| publishDate | 2023 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1103952025-05-14T08:00:36Z http://psasir.upm.edu.my/id/eprint/110395/ Lycopene in feed as antioxidant and immuno-modulator improves broiler chickens performance under heat-stress conditions Hidayat, Dalila Fadhila Mahendra, Mohamad Yusril Nur Kamaludeen, Juriah Pertiwi, Herinda Lycopene is a type of carotenoid pigment widely distributed in various plants and fruits, with tomatoes, carrots, and guava being the most abundant sources. Due to its high content of beneficial active components, lycopene has been used in medicine, where it is employed as a dietary additive for cancer therapy, immune modulator, and feed additive to improve livestock productivity. Lycopene is a lipophilic substance that can act as either a prooxidant or a free radical scavenger and is particularly efficient in enhancing broiler performance. Furthermore, lycopene can alleviate heat stress by improving the activity of various antioxidant enzymes such as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT), as well as increasing the total antioxidant capacity (T-AOC) and nuclear muscle factor erythroid 2-related factor 2 (Nrf2), while simultaneously reducing the levels of malondialdehyde (MDA) and muscle Keap1 expression. In addition, lycopene can improve broiler fertility by enhancing sperm performance and reducing inflammation by modulating the levels of interleukin 1, 2, and 10 (IL-1, IL-2, and IL-10) in cases of infection. In cases of disease by aflatoxin B1 (AFB1), lycopene can modulate interferon-γ (IFN-γ), IL-1, claudin-1 (CLDN-1), and zonula occludens-1 (ZO-1). Furthermore, under the lipopolysaccharide challenge, lycopene can increase the relative weights of immune organ indices such as the bursal, spleen, and thymus. Wiley 2023 Article PeerReviewed text en cc_by_4 http://psasir.upm.edu.my/id/eprint/110395/1/110395.pdf Hidayat, Dalila Fadhila and Mahendra, Mohamad Yusril Nur and Kamaludeen, Juriah and Pertiwi, Herinda (2023) Lycopene in feed as antioxidant and immuno-modulator improves broiler chickens performance under heat-stress conditions. Veterinary Medicine International, 2023 (1). art. no. 5418081. pp. 1-7. ISSN 2090-8113; eISSN: 2042-0048 https://onlinelibrary.wiley.com/doi/10.1155/2023/5418081 10.1155/2023/5418081 |
| spellingShingle | Hidayat, Dalila Fadhila Mahendra, Mohamad Yusril Nur Kamaludeen, Juriah Pertiwi, Herinda Lycopene in feed as antioxidant and immuno-modulator improves broiler chickens performance under heat-stress conditions |
| title | Lycopene in feed as antioxidant and immuno-modulator improves broiler chickens performance under heat-stress conditions |
| title_full | Lycopene in feed as antioxidant and immuno-modulator improves broiler chickens performance under heat-stress conditions |
| title_fullStr | Lycopene in feed as antioxidant and immuno-modulator improves broiler chickens performance under heat-stress conditions |
| title_full_unstemmed | Lycopene in feed as antioxidant and immuno-modulator improves broiler chickens performance under heat-stress conditions |
| title_short | Lycopene in feed as antioxidant and immuno-modulator improves broiler chickens performance under heat-stress conditions |
| title_sort | lycopene in feed as antioxidant and immuno-modulator improves broiler chickens performance under heat-stress conditions |
| url | http://psasir.upm.edu.my/id/eprint/110395/ http://psasir.upm.edu.my/id/eprint/110395/ http://psasir.upm.edu.my/id/eprint/110395/ http://psasir.upm.edu.my/id/eprint/110395/1/110395.pdf |