Antihyperlipidemic, hepatoprotective and nephroprotective effects functional beverages containing soybean (Glycine max L.), sweet potato leaves (Ipomoea batatas L.), and red yeast rice on a high fat diet rats
One of the primary risk factors for hyperlipidemia is an excessively high-fat diet. Due to their phytochemical composition and biological activity, red yeast rice (RYR), sweet potato (Ipomoea batatas L.) leaves and soybeans (Glycine max L.) are known to possess antihyperlipidemia and antioxidants ef...
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| Format: | Article |
| Language: | English |
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Biome Scientia
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/110374/ http://psasir.upm.edu.my/id/eprint/110374/1/134-Article%20File%20-%20PDF-1348-3-10-20240409.pdf |
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| author | Mahfudh, Nurkhasanah Sari, Atika Orchida Ikhtiari, Iradatul Sulistyani, Nanik Kumalasari, Ika Dyah Othman, Fezah |
| author_facet | Mahfudh, Nurkhasanah Sari, Atika Orchida Ikhtiari, Iradatul Sulistyani, Nanik Kumalasari, Ika Dyah Othman, Fezah |
| author_sort | Mahfudh, Nurkhasanah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | One of the primary risk factors for hyperlipidemia is an excessively high-fat diet. Due to their phytochemical composition and biological activity, red yeast rice (RYR), sweet potato (Ipomoea batatas L.) leaves and soybeans (Glycine max L.) are known to possess antihyperlipidemia and antioxidants effects. The purpose of this study is to ascertain how beverages containing soybeans, sweet potato leaves, and red yeast rice affect rats fed a high-fat diet in terms of hyperlipidemia, liver damage, and kidney damage. Five groups of rats were used: normal control, positive control using Commercial Smoothie Drink 1 (CSD1), 3.6 ml/day, negative control, and treatment groups receiving beverage doses of 1250 mg/kg and 2500 mg/kg respectively. Following the induction of the high-fat diet in the animals, functional beverage treatment was administered for 14 days starting on day 15 for a total of 28 days. The findings demonstrated that in rats fed a high-fat diet, the administration of functional beverages at a dose of 2500 mg/kg significantly (p<0.05) decreased serum levels of cholesterol, triglyceride, creatinine, blood urea nitrogen, serum glutamic pyruvic transaminase (SGPT) and serum glutamic oxaloacetic transaminase (SGOT). It is concluded that functional beverages may offer protection against hyperlipidemia, liver, and kidney damage caused by a high-fat diet. |
| first_indexed | 2025-11-15T14:05:49Z |
| format | Article |
| id | upm-110374 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:05:49Z |
| publishDate | 2024 |
| publisher | Biome Scientia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1103742024-09-03T02:54:47Z http://psasir.upm.edu.my/id/eprint/110374/ Antihyperlipidemic, hepatoprotective and nephroprotective effects functional beverages containing soybean (Glycine max L.), sweet potato leaves (Ipomoea batatas L.), and red yeast rice on a high fat diet rats Mahfudh, Nurkhasanah Sari, Atika Orchida Ikhtiari, Iradatul Sulistyani, Nanik Kumalasari, Ika Dyah Othman, Fezah One of the primary risk factors for hyperlipidemia is an excessively high-fat diet. Due to their phytochemical composition and biological activity, red yeast rice (RYR), sweet potato (Ipomoea batatas L.) leaves and soybeans (Glycine max L.) are known to possess antihyperlipidemia and antioxidants effects. The purpose of this study is to ascertain how beverages containing soybeans, sweet potato leaves, and red yeast rice affect rats fed a high-fat diet in terms of hyperlipidemia, liver damage, and kidney damage. Five groups of rats were used: normal control, positive control using Commercial Smoothie Drink 1 (CSD1), 3.6 ml/day, negative control, and treatment groups receiving beverage doses of 1250 mg/kg and 2500 mg/kg respectively. Following the induction of the high-fat diet in the animals, functional beverage treatment was administered for 14 days starting on day 15 for a total of 28 days. The findings demonstrated that in rats fed a high-fat diet, the administration of functional beverages at a dose of 2500 mg/kg significantly (p<0.05) decreased serum levels of cholesterol, triglyceride, creatinine, blood urea nitrogen, serum glutamic pyruvic transaminase (SGPT) and serum glutamic oxaloacetic transaminase (SGOT). It is concluded that functional beverages may offer protection against hyperlipidemia, liver, and kidney damage caused by a high-fat diet. Biome Scientia 2024 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/110374/1/134-Article%20File%20-%20PDF-1348-3-10-20240409.pdf Mahfudh, Nurkhasanah and Sari, Atika Orchida and Ikhtiari, Iradatul and Sulistyani, Nanik and Kumalasari, Ika Dyah and Othman, Fezah (2024) Antihyperlipidemic, hepatoprotective and nephroprotective effects functional beverages containing soybean (Glycine max L.), sweet potato leaves (Ipomoea batatas L.), and red yeast rice on a high fat diet rats. Life Sciences, Medicine and Biomedicine, 8 (1). pp. 1-10. ISSN 2600-7207 https://biomescientia.com/index.php/lsmb/article/view/134 10.28916/lsmb.8.1.2024.134 |
| spellingShingle | Mahfudh, Nurkhasanah Sari, Atika Orchida Ikhtiari, Iradatul Sulistyani, Nanik Kumalasari, Ika Dyah Othman, Fezah Antihyperlipidemic, hepatoprotective and nephroprotective effects functional beverages containing soybean (Glycine max L.), sweet potato leaves (Ipomoea batatas L.), and red yeast rice on a high fat diet rats |
| title | Antihyperlipidemic, hepatoprotective and nephroprotective effects functional beverages containing soybean (Glycine max L.), sweet potato leaves (Ipomoea batatas L.), and red yeast rice on a high fat diet rats |
| title_full | Antihyperlipidemic, hepatoprotective and nephroprotective effects functional beverages containing soybean (Glycine max L.), sweet potato leaves (Ipomoea batatas L.), and red yeast rice on a high fat diet rats |
| title_fullStr | Antihyperlipidemic, hepatoprotective and nephroprotective effects functional beverages containing soybean (Glycine max L.), sweet potato leaves (Ipomoea batatas L.), and red yeast rice on a high fat diet rats |
| title_full_unstemmed | Antihyperlipidemic, hepatoprotective and nephroprotective effects functional beverages containing soybean (Glycine max L.), sweet potato leaves (Ipomoea batatas L.), and red yeast rice on a high fat diet rats |
| title_short | Antihyperlipidemic, hepatoprotective and nephroprotective effects functional beverages containing soybean (Glycine max L.), sweet potato leaves (Ipomoea batatas L.), and red yeast rice on a high fat diet rats |
| title_sort | antihyperlipidemic, hepatoprotective and nephroprotective effects functional beverages containing soybean (glycine max l.), sweet potato leaves (ipomoea batatas l.), and red yeast rice on a high fat diet rats |
| url | http://psasir.upm.edu.my/id/eprint/110374/ http://psasir.upm.edu.my/id/eprint/110374/ http://psasir.upm.edu.my/id/eprint/110374/ http://psasir.upm.edu.my/id/eprint/110374/1/134-Article%20File%20-%20PDF-1348-3-10-20240409.pdf |