Paediatric new onset type 1 diabetes and diabetic ketoacidosis during the COVID-19 pandemic in Malaysia
Aims: Despite emerging evidence of increased paediatric diabetes mellitus (DM) and diabetic ketoacidosis (DKA) worldwide following the COVID-19 pandemic, studies in Asia are lacking. We aimed to determine the frequency, demographics, and clinical characteristics of new onset type 1 DM (T1DM) during...
| Main Authors: | , , , , , |
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| Format: | Article |
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Elsevier Ireland
2023
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| Online Access: | http://psasir.upm.edu.my/id/eprint/110127/ |
| _version_ | 1848865440277725184 |
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| author | Yee, Lin Lee Wan Ahmad Nasir, Fatin Farihah Selveindran, Nalini M Anuar Zaini, Azriyanti Poi, Giok Lim Jalaludin, Muhammad Yazid |
| author_facet | Yee, Lin Lee Wan Ahmad Nasir, Fatin Farihah Selveindran, Nalini M Anuar Zaini, Azriyanti Poi, Giok Lim Jalaludin, Muhammad Yazid |
| author_sort | Yee, Lin Lee |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Aims: Despite emerging evidence of increased paediatric diabetes mellitus (DM) and diabetic ketoacidosis (DKA) worldwide following the COVID-19 pandemic, studies in Asia are lacking. We aimed to determine the frequency, demographics, and clinical characteristics of new onset type 1 DM (T1DM) during the pandemic in Malaysia. Methods: This is a retrospective multicenter study involving new onset T1DM paediatric patients in Klang Valley, Malaysia during two time periods ie 18th September 2017-17th March 2020 (pre-pandemic) and 18th March 2020-17th September 2022 (pandemic). Results: There was a total of 180 patients with new onset T1DM during the 5-year study period (71 pre-pandemic, 109 pandemic). An increase in frequency of T1DM was observed during the pandemic (52 in 2021, 38 in 2020, 27 in 2019 and 30 in 2018). A significantly greater proportion of patients presented with DKA (79.8 vs 64.8), especially severe DKA (46.8 vs 28.2) during the pandemic. Serum glucose was significantly higher (28.2 mmol vs 25.9 mmol/L) with lower venous pH (7.10 vs 7.16), but HbA1c was unchanged. Conclusions: New onset T1DM increased during the pandemic, with a greater proportion having severe DKA. Further studies are required to evaluate the mechanism leading to this rise to guide intervention measures. |
| first_indexed | 2025-11-15T14:04:44Z |
| format | Article |
| id | upm-110127 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T14:04:44Z |
| publishDate | 2023 |
| publisher | Elsevier Ireland |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1101272024-09-04T04:26:22Z http://psasir.upm.edu.my/id/eprint/110127/ Paediatric new onset type 1 diabetes and diabetic ketoacidosis during the COVID-19 pandemic in Malaysia Yee, Lin Lee Wan Ahmad Nasir, Fatin Farihah Selveindran, Nalini M Anuar Zaini, Azriyanti Poi, Giok Lim Jalaludin, Muhammad Yazid Aims: Despite emerging evidence of increased paediatric diabetes mellitus (DM) and diabetic ketoacidosis (DKA) worldwide following the COVID-19 pandemic, studies in Asia are lacking. We aimed to determine the frequency, demographics, and clinical characteristics of new onset type 1 DM (T1DM) during the pandemic in Malaysia. Methods: This is a retrospective multicenter study involving new onset T1DM paediatric patients in Klang Valley, Malaysia during two time periods ie 18th September 2017-17th March 2020 (pre-pandemic) and 18th March 2020-17th September 2022 (pandemic). Results: There was a total of 180 patients with new onset T1DM during the 5-year study period (71 pre-pandemic, 109 pandemic). An increase in frequency of T1DM was observed during the pandemic (52 in 2021, 38 in 2020, 27 in 2019 and 30 in 2018). A significantly greater proportion of patients presented with DKA (79.8 vs 64.8), especially severe DKA (46.8 vs 28.2) during the pandemic. Serum glucose was significantly higher (28.2 mmol vs 25.9 mmol/L) with lower venous pH (7.10 vs 7.16), but HbA1c was unchanged. Conclusions: New onset T1DM increased during the pandemic, with a greater proportion having severe DKA. Further studies are required to evaluate the mechanism leading to this rise to guide intervention measures. Elsevier Ireland 2023 Article PeerReviewed Yee, Lin Lee and Wan Ahmad Nasir, Fatin Farihah and Selveindran, Nalini M and Anuar Zaini, Azriyanti and Poi, Giok Lim and Jalaludin, Muhammad Yazid (2023) Paediatric new onset type 1 diabetes and diabetic ketoacidosis during the COVID-19 pandemic in Malaysia. Diabetes Research and Clinical Practice, 205. art. no. 110981. pp. 1-5. ISSN 0168-8227; ESSN: 1872-8227 https://linkinghub.elsevier.com/retrieve/pii/S0168822723007441 10.1016/j.diabres.2023.110981 |
| spellingShingle | Yee, Lin Lee Wan Ahmad Nasir, Fatin Farihah Selveindran, Nalini M Anuar Zaini, Azriyanti Poi, Giok Lim Jalaludin, Muhammad Yazid Paediatric new onset type 1 diabetes and diabetic ketoacidosis during the COVID-19 pandemic in Malaysia |
| title | Paediatric new onset type 1 diabetes and diabetic ketoacidosis during the COVID-19 pandemic in Malaysia |
| title_full | Paediatric new onset type 1 diabetes and diabetic ketoacidosis during the COVID-19 pandemic in Malaysia |
| title_fullStr | Paediatric new onset type 1 diabetes and diabetic ketoacidosis during the COVID-19 pandemic in Malaysia |
| title_full_unstemmed | Paediatric new onset type 1 diabetes and diabetic ketoacidosis during the COVID-19 pandemic in Malaysia |
| title_short | Paediatric new onset type 1 diabetes and diabetic ketoacidosis during the COVID-19 pandemic in Malaysia |
| title_sort | paediatric new onset type 1 diabetes and diabetic ketoacidosis during the covid-19 pandemic in malaysia |
| url | http://psasir.upm.edu.my/id/eprint/110127/ http://psasir.upm.edu.my/id/eprint/110127/ http://psasir.upm.edu.my/id/eprint/110127/ |