Performance of Alkyl β-D-maltosides in molecular self-assembly and formation of oil-in-water nanoemulsions as drug delivery systems
Alkyl β-D-maltosides (C8-C12) are nonionic sugar-based surfactants and categorized as oil-in-water (O/W) emulsifiers with hydrophilic-lipophilic balance (HLB) between 13 and 15. The self-assembly of the alkyl β-D-maltosides was investigated in binary (surfactants and water) and ternary (surfactants,...
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| Format: | Article |
| Language: | English |
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Elsevier B.V.
2023
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| Online Access: | http://psasir.upm.edu.my/id/eprint/110121/ http://psasir.upm.edu.my/id/eprint/110121/1/110121.pdf |
| _version_ | 1848865439019433984 |
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| author | Mohd Nordin, Ummu Umaimah Ahmad, Noraini Salim, Norazlinaliza Tajuddin, Hairul Anuar Abu Bakar, Noor Fitrah Narasimhan, Ashwin Kumar |
| author_facet | Mohd Nordin, Ummu Umaimah Ahmad, Noraini Salim, Norazlinaliza Tajuddin, Hairul Anuar Abu Bakar, Noor Fitrah Narasimhan, Ashwin Kumar |
| author_sort | Mohd Nordin, Ummu Umaimah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Alkyl β-D-maltosides (C8-C12) are nonionic sugar-based surfactants and categorized as oil-in-water (O/W) emulsifiers with hydrophilic-lipophilic balance (HLB) between 13 and 15. The self-assembly of the alkyl β-D-maltosides was investigated in binary (surfactants and water) and ternary (surfactants, oil and water) systems as single and mixed nonionic surfactants with Tween 80 (T80, C18:1). The critical aggregation concentration (CAC) of alkyl β-D-maltosides/water and T80/alkyl β-D-maltosides/water decreased as the alkyl chain length of alkyl β-D-maltosides increased. The nanoemulsion systems of T80/alkyl β-D-maltosides/medium-chain triglycerides (MCT) oil/water were formulated with and without cyclosporine (CsA) as the hydrophobic model drug by the phase inversion composition (PIC) method. The particle size and polydispersity index (PDI) decreased in the following order: T80/OM > T80/DM > T80 > T80/DDM. Significantly, the hydrophobic effect in mixed nonionic surfactants was strongest for DDM by enhancing the stability of T80 nanoemulsion in molecular self-assembly. The nanoemulsions were homogenous in size, ellipsoidal and spherical in shape and stable at room temperature for 28 days. The T80/DDM nanoemulsion also improved the cumulative CsA released in 24 h at 98.33 ± 7.72% and had no cytotoxicity effect (IC50) up to 500 mg/mL concentration against 3T3 cells. |
| first_indexed | 2025-11-15T14:04:43Z |
| format | Article |
| id | upm-110121 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:04:43Z |
| publishDate | 2023 |
| publisher | Elsevier B.V. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1101212025-07-02T09:21:40Z http://psasir.upm.edu.my/id/eprint/110121/ Performance of Alkyl β-D-maltosides in molecular self-assembly and formation of oil-in-water nanoemulsions as drug delivery systems Mohd Nordin, Ummu Umaimah Ahmad, Noraini Salim, Norazlinaliza Tajuddin, Hairul Anuar Abu Bakar, Noor Fitrah Narasimhan, Ashwin Kumar Alkyl β-D-maltosides (C8-C12) are nonionic sugar-based surfactants and categorized as oil-in-water (O/W) emulsifiers with hydrophilic-lipophilic balance (HLB) between 13 and 15. The self-assembly of the alkyl β-D-maltosides was investigated in binary (surfactants and water) and ternary (surfactants, oil and water) systems as single and mixed nonionic surfactants with Tween 80 (T80, C18:1). The critical aggregation concentration (CAC) of alkyl β-D-maltosides/water and T80/alkyl β-D-maltosides/water decreased as the alkyl chain length of alkyl β-D-maltosides increased. The nanoemulsion systems of T80/alkyl β-D-maltosides/medium-chain triglycerides (MCT) oil/water were formulated with and without cyclosporine (CsA) as the hydrophobic model drug by the phase inversion composition (PIC) method. The particle size and polydispersity index (PDI) decreased in the following order: T80/OM > T80/DM > T80 > T80/DDM. Significantly, the hydrophobic effect in mixed nonionic surfactants was strongest for DDM by enhancing the stability of T80 nanoemulsion in molecular self-assembly. The nanoemulsions were homogenous in size, ellipsoidal and spherical in shape and stable at room temperature for 28 days. The T80/DDM nanoemulsion also improved the cumulative CsA released in 24 h at 98.33 ± 7.72% and had no cytotoxicity effect (IC50) up to 500 mg/mL concentration against 3T3 cells. Elsevier B.V. 2023-06 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/110121/1/110121.pdf Mohd Nordin, Ummu Umaimah and Ahmad, Noraini and Salim, Norazlinaliza and Tajuddin, Hairul Anuar and Abu Bakar, Noor Fitrah and Narasimhan, Ashwin Kumar (2023) Performance of Alkyl β-D-maltosides in molecular self-assembly and formation of oil-in-water nanoemulsions as drug delivery systems. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 674. art. no. 131886. pp. 1-15. ISSN 0927-7757; eISSN: 1873-4359 https://www.sciencedirect.com/science/article/pii/S0927775723009706 10.1016/j.colsurfa.2023.131886 |
| spellingShingle | Mohd Nordin, Ummu Umaimah Ahmad, Noraini Salim, Norazlinaliza Tajuddin, Hairul Anuar Abu Bakar, Noor Fitrah Narasimhan, Ashwin Kumar Performance of Alkyl β-D-maltosides in molecular self-assembly and formation of oil-in-water nanoemulsions as drug delivery systems |
| title | Performance of Alkyl β-D-maltosides in molecular self-assembly and formation of oil-in-water nanoemulsions as drug delivery systems |
| title_full | Performance of Alkyl β-D-maltosides in molecular self-assembly and formation of oil-in-water nanoemulsions as drug delivery systems |
| title_fullStr | Performance of Alkyl β-D-maltosides in molecular self-assembly and formation of oil-in-water nanoemulsions as drug delivery systems |
| title_full_unstemmed | Performance of Alkyl β-D-maltosides in molecular self-assembly and formation of oil-in-water nanoemulsions as drug delivery systems |
| title_short | Performance of Alkyl β-D-maltosides in molecular self-assembly and formation of oil-in-water nanoemulsions as drug delivery systems |
| title_sort | performance of alkyl β-d-maltosides in molecular self-assembly and formation of oil-in-water nanoemulsions as drug delivery systems |
| url | http://psasir.upm.edu.my/id/eprint/110121/ http://psasir.upm.edu.my/id/eprint/110121/ http://psasir.upm.edu.my/id/eprint/110121/ http://psasir.upm.edu.my/id/eprint/110121/1/110121.pdf |