Structural complexity and physical mechanism of self-assembled lipid as nanocarriers: A review
Lipids such as glyceryl monooleate, phosphatidylcholine, and monoglyceride (CITREM) possess an amphipathic property that allows them to self-assemble into a complex internal structure when interacting with an aqueous solution. Since amphiphilic molecules possess hydrophilic heads and lipophilic tail...
| Main Authors: | , , , , |
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| Format: | Article |
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Malaysian Society of Molecular Biology and Biotechnology
2023
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| Online Access: | http://psasir.upm.edu.my/id/eprint/110061/ |
| _version_ | 1848865422006288384 |
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| author | Ilias, Nazhan Richmond, Rocky Vester Selvarajah, Gayathri Thevi Mat Azmi, Intan Diana Ajat, Mokrish |
| author_facet | Ilias, Nazhan Richmond, Rocky Vester Selvarajah, Gayathri Thevi Mat Azmi, Intan Diana Ajat, Mokrish |
| author_sort | Ilias, Nazhan |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Lipids such as glyceryl monooleate, phosphatidylcholine, and monoglyceride (CITREM) possess an amphipathic property that allows them to self-assemble into a complex internal structure when interacting with an aqueous solution. Since amphiphilic molecules possess hydrophilic heads and lipophilic tails, hydrophobic effects cause the spontaneous activity of the molecular rearrangement. The self-organization of the molecules often results in the phases of lipid polymorphism, for example microemulsion, inverse bicontinuous cubic (Q2), discontinuous hexagonal (H2), and micellar cubic (I2) Fd3m. Interestingly, these lamellar and non-lamellar phases have been applied in the development of nanocarriers for drug delivery due to their ability to provide a sustained drug release system, better drug bioavailability, and improved overall treatment. However, the attention that they are receiving from their application is not comparable to our understanding of the mechanisms involved in their synthesis. Elucidation of the spontaneous process helps in predicting and tuning the internal structure of an amphiphilic molecule to suit its application. Therefore, this review discusses the formation of lipid polymorphism from the thermodynamic point of view, critical packing parameter, and modified stalk theory. |
| first_indexed | 2025-11-15T14:04:27Z |
| format | Article |
| id | upm-110061 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T14:04:27Z |
| publishDate | 2023 |
| publisher | Malaysian Society of Molecular Biology and Biotechnology |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1100612024-09-10T06:36:09Z http://psasir.upm.edu.my/id/eprint/110061/ Structural complexity and physical mechanism of self-assembled lipid as nanocarriers: A review Ilias, Nazhan Richmond, Rocky Vester Selvarajah, Gayathri Thevi Mat Azmi, Intan Diana Ajat, Mokrish Lipids such as glyceryl monooleate, phosphatidylcholine, and monoglyceride (CITREM) possess an amphipathic property that allows them to self-assemble into a complex internal structure when interacting with an aqueous solution. Since amphiphilic molecules possess hydrophilic heads and lipophilic tails, hydrophobic effects cause the spontaneous activity of the molecular rearrangement. The self-organization of the molecules often results in the phases of lipid polymorphism, for example microemulsion, inverse bicontinuous cubic (Q2), discontinuous hexagonal (H2), and micellar cubic (I2) Fd3m. Interestingly, these lamellar and non-lamellar phases have been applied in the development of nanocarriers for drug delivery due to their ability to provide a sustained drug release system, better drug bioavailability, and improved overall treatment. However, the attention that they are receiving from their application is not comparable to our understanding of the mechanisms involved in their synthesis. Elucidation of the spontaneous process helps in predicting and tuning the internal structure of an amphiphilic molecule to suit its application. Therefore, this review discusses the formation of lipid polymorphism from the thermodynamic point of view, critical packing parameter, and modified stalk theory. Malaysian Society of Molecular Biology and Biotechnology 2023 Article PeerReviewed Ilias, Nazhan and Richmond, Rocky Vester and Selvarajah, Gayathri Thevi and Mat Azmi, Intan Diana and Ajat, Mokrish (2023) Structural complexity and physical mechanism of self-assembled lipid as nanocarriers: A review. Asia-Pacific Journal of Molecular Biology and Biotechnology, 31 (2). pp. 26-35. ISSN 0128-7451; ESSN:2672-7277 http://msmbb.my/images/publication/volume_31/issue_2/02-Ilias-et-al.pdf 10.35118/apjmbb.2023.031.2.02 |
| spellingShingle | Ilias, Nazhan Richmond, Rocky Vester Selvarajah, Gayathri Thevi Mat Azmi, Intan Diana Ajat, Mokrish Structural complexity and physical mechanism of self-assembled lipid as nanocarriers: A review |
| title | Structural complexity and physical mechanism of self-assembled lipid as nanocarriers: A review |
| title_full | Structural complexity and physical mechanism of self-assembled lipid as nanocarriers: A review |
| title_fullStr | Structural complexity and physical mechanism of self-assembled lipid as nanocarriers: A review |
| title_full_unstemmed | Structural complexity and physical mechanism of self-assembled lipid as nanocarriers: A review |
| title_short | Structural complexity and physical mechanism of self-assembled lipid as nanocarriers: A review |
| title_sort | structural complexity and physical mechanism of self-assembled lipid as nanocarriers: a review |
| url | http://psasir.upm.edu.my/id/eprint/110061/ http://psasir.upm.edu.my/id/eprint/110061/ http://psasir.upm.edu.my/id/eprint/110061/ |