REST targets JAK–STAT and HIF-1 signaling pathways in human Down syndrome brain and neural cells

QR Code

REST targets JAK–STAT and HIF-1 signaling pathways in human Down syndrome brain and neural cells

Down syndrome (DS) is the most frequently diagnosed chromosomal disorder of chromosome 21 (HSA21) aneuploidy, characterized by intellectual disability and reduced lifespan. The transcription repressor, Repressor Element-1 Silencing Transcription factor (REST), which acts as an epigenetic regulator,...

Full description

Bibliographic Details
Main Authors:	Huang, Tan, Fakurazi, Sharida, Cheah, Pike-See, Ling, King-Hwa
Format:	Article
Language:	English
Published:	Multidisciplinary Digital Publishing Institute 2023
Online Access:	http://psasir.upm.edu.my/id/eprint/109464/ http://psasir.upm.edu.my/id/eprint/109464/1/ijms-24-09980.pdf

Similar Items

Potential role of JAK-STAT signaling pathway in the neurogenic-to-gliogenic shift in down syndrome brain
by: Lee, Han Chung, et al.
Published: (2016)

The role of JAK-STAT signalling in the developing brain of Ts1Cje mouse model for Down syndrome
by: Lee, Han Chung, et al.
Published: (2015)

Dysregulation of REST and its target genes impacts the fate of neural progenitor cells in down syndrome
by: Tan, Huang, et al.
Published: (2025)

The restoration of REST inhibits reactivity of Down syndrome iPSC-derived astrocytes
by: Huang, Tan, et al.
Published: (2025)

Gene and protein expression profiles of JAK-STAT signalling pathway in the developing brain of the Ts1Cje down syndrome mouse model
by: Lee, Han Chung, et al.
Published: (2019)

Chromosomal and cellular therapeutic approaches for Down syndrome: a research update
by: Huang, Tan, et al.
Published: (2024)

Lithium restores nuclear REST and Mitigates oxidative stress in down syndrome iPSC-Derived neurons
by: Lam, Xin-Jieh, et al.
Published: (2025)

Reduced REST expression in neural progenitor cells, adult cortex, and impaired REST nuclear translocation in the prefrontal cortex of Ts1Cje mouse model of Down Syndrome
by: Chong, Teik Lim, et al.
Published: (2024)

Brain insulin resistance in down syndrome: involvement of PI3K-AKT/MTOR axis in early-onset of Alzheimer's disease and its potential as a therapeutic target
by: Azimzadeh, Mansour, et al.
Published: (2024)

Understanding perspectives and research trends in down syndrome neuropathogenesis: a bibliometric analysis
by: Huang, Tan, et al.
Published: (2024)

Mitochondrial dysfunction in Down Syndrome: from pathology to therapy
by: Tan, Kai-Leng, et al.
Published: (2023)

Expression profiling of notch signalling pathway and gamma-secretase activity in the brain of Ts1Cje mouse model of down syndrome
by: Md Yusof, Hadri Hadi, et al.
Published: (2019)

Expression profiling of genes involved in the development and function of skeletal muscles in Ts1Cje mouse model of down syndrome
by: Cheah, Pike See, et al.
Published: (2018)

Transcriptional profiling of the postnatal brain of the Ts1Cje mouse model of Down syndrome
by: Tan, Kai Leng, et al.
Published: (2014)

Overexpression of interferon alpha or beta receptors in the brain of adult Ts1Cje mouse model of Down syndrome
by: Tan, Kai Leng, et al.
Published: (2015)

MicroRNAs and intellectual disability (ID) in Down syndrome, X-linked ID and Fragile X syndrome
by: Siew, Wei Hong, et al.
Published: (2013)

Targeted differential gene expression profiling of skeletal muscles isolated from Ts1Cje mouse model for Down syndrome
by: Leong, Melody Pui Yee, et al.
Published: (2015)

Disrupted interferon-related molecular networks and the over-expressed Ifnar1 in the brain of adult Ts1Cje mouse model of Down syndrome
by: Tan, Kai Leng, et al.
Published: (2016)

Polyphenols mitigating inflammatory mechanisms in Inflammatory Bowel Disease (IBD): focus on NF-κB and JAK/STAT pathways
by: Ismail, Elysha Nur, et al.
Published: (2024)

The mechanism of action of the negative Regulators of jak/stat singnaling pathway in Resistant FLT-ITD acute myeloid leukaemia cells
by: Johan, Muhammad Farid
Published: (2019)

Novel quinazoline-based sulfonamide derivative (3D) induces apoptosis in colorectal cancer by inhibiting JAK2–STAT3 pathway
by: Al-Obeed, Omar A., et al.
Published: (2018)

Ts1Cje mouse model for Down syndrome research
by: Ling, King Hwa
Published: (2015)

Ts1Cje mouse model for Down syndrome exhibits motor function deficit; the potential role of MRFS and peripheral nervous system
by: Bala, Usman, et al.
Published: (2015)

The expression profile of miR-3099 during neural development of Ts1Cje mouse model of down syndrome
by: Zainal Abidin, Shahidee, et al.
Published: (2021)

Gene aberrations and methylation analysis of JAK/stat and toll-like receptor downstream signalling in BCR-ABL-negative myeloproliferative neoplasms and myelodysplastic syndrome/myeloproliferative neoplasms overlap syndromes
by: Cai, Chia Yuh
Published: (2021)

Functional transcriptome analysis of the postnatal brain of the Ts1Cje mouse model for Down syndrome reveals global disruption of interferon-related molecular networks
by: Ling, King Hwa, et al.
Published: (2014)

smART Brain
by: Cheah, Pike See
Published: (2016)

Jak3, STAT3, and STAT5 inhibit expression of miR-22, a novel tumor suppressor microRNA, in cutaneous T-Cell lymphoma
by: Sibbesen, Nina A., et al.
Published: (2015)

Effects of bortezomib on HIF-1 and HIF-2 transcriptional activities
by: Abd Aziz, Noraini
Published: (2013)

An azaspirane derivative suppresses growth and induces apoptosis of ER-positive and ER-negative breast cancer cells through the modulation of JAK2/STAT3 signaling pathway
by: Sulaiman, N., et al.
Published: (2016)

Acquired radioresistance in EMT6 mouse mammary carcinoma cell line is mediated by CTLA-4 and PD-1 throughJAK/STAT/PI3K pathway
by: Ronny Sham, Nur Fatihah, et al.
Published: (2023)

The identification of disrupted molecular networks involved in brain maturation and function in the Ts1Cje mouse model of down syndrome.
by: Cheah, P. S.

Perturbed metabolic profiles associated with muscle weakness seen in adult Ts1Cje mouse model of Down syndrome
by: Lim, Chai Ling, et al.
Published: (2019)

Targeting the STAT3 signaling pathway in cancer: Role of synthetic and natural inhibitors
by: Siveen, K., et al.
Published: (2013)

Bortezomib attenuates HIF-1- but not HIF-2-mediated transcriptional activation
by: Abd Aziz, Noraini, et al.
Published: (2015)

Exogenous dihydrosphingosine 1 phosphate mediates collagen synthesis in cardiac fibroblasts through JAK/STAT signalling and regulation of TIMP1
by: Magaye, R.R., et al.
Published: (2020)

Introduction : brain science : inside out
by: Cheah, Pike See
Published: (2016)

Challenges and future perspectives for 3D cerebral organoids as a model for complex brain disorders
by: Cheah, Pike See, et al.
Published: (2019)

Effects of knocking-down HIF-la on migration in human breast cancer cell MDA-MB-231
by: Rashid, Nur Sabrina Abd
Published: (2015)

STAT2 is a pervasive cytokine regulator due to its inhibition of STAT1 in multiple signaling pathways
by: Ho, Johnathan, et al.
Published: (2016)