Insight parameter drug design for human β-tryptase inhibition integrated molecular docking, QSAR, molecular dynamics simulation, and pharmacophore modelling studies of α-keto-[1,2,4]-oxadiazoles

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Insight parameter drug design for human β-tryptase inhibition integrated molecular docking, QSAR, molecular dynamics simulation, and pharmacophore modelling studies of α-keto-[1,2,4]-oxadiazoles

Dengue hemorrhagic fever (DHF) is life-threatening severe dengue with a hallmark of vascular leakage. A mast cell protease, β-tryptase, has been found to promote vascular leakage in DHF patients, which could be a potential target for the treatment of DHF. This study aims to develop a theoretical bac...

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Bibliographic Details
Main Authors:	Yu, Chai Xin, Tan, Jian Wei, Rullah, Kamal, Imran, Syahrul, Tham, Chau Ling
Format:	Article
Published:	Taylor and Francis Group 2023
Online Access:	http://psasir.upm.edu.my/id/eprint/109433/

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